
Makinson Lab
94 posts

Makinson Lab
@MakinsonLab
Team of creative scientists working to understand the biological basis of neurodevelopmental disease in the Institute for Genomic Medicine at Columbia


Today, I’m thrilled have our lab’s work featured on the cover of @Nature In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel. Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain. Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.













Wonderful things are happening @EmoryUniversity! With @jimena_andersen and @fikribirey, we are developing the Brain Organoid Hub brainorganoidhub.com We are recruiting postdocs who want to participate in truly collaborative science using cutting-edge organoid/assembloid models

Wonderful things are happening @EmoryUniversity! With @jimena_andersen and @fikribirey, we are developing the Brain Organoid Hub brainorganoidhub.com We are recruiting postdocs who want to participate in truly collaborative science using cutting-edge organoid/assembloid models

Applications for our @Stanford hands-on course on making, probing and manipulating neural #organoids & #assembloids is now open. @BrOrganogenesis @StanfordBrain @StanfordBioX This is a tuition free course Deadline: Nov 1, 2022 Details on applying👇 brainorganogenesis.org







