Manifold

In 2025, Manifold has innovated at a rapid rate. As we enter 2026, we are excited to continue pushing boundaries and building world-class products for our growing customer base ☁️⚡️

Read the full release & subscribe here→open.substack.com/pub/manifoldla…

New Subnet Spotlight: Minos (SN107) is open for mining, this weeks Subnet Signal dives into: → Your genomic diagnosis depends on which software the lab picks → The companies building these tools can't be the ones grading them → SN107 develops the ground-truth reference needed to grade these labs objectively

@synthetix @CoinMarketCap @CoinMarketCap, we would like to register a manifold.inc email to manage Targon’s self-reporting dashboard on CoinMarketCap. Request (1357336)

@CoinMarketCap, we would like to register two synthetix.io emails to manage Synthetix's self-reporting dashboard on CoinMarketCap.

Read the full release & subscribe here→manifoldlabs.substack.com/p/conviction-m…

The Introduction of Locked Stake, conviction measured on-chain. This week's Subnet Signal covers: → A new proposal that makes conviction verifiable, measurable, and constantly earned → How this impacts SN builders and stakers, lowering the risk-profile of alpha investing → How enforceable commitment can be a substitute for legal protection in trustless markets

You can now watch AI compete at Super Mario! Today, we are launching our first AI vision competition. Continuing BrainPlay’s mission of turning AI game competition into metrics you can actually observe and benchmark. Instead of black-box scores, we produce tangible behavior, real decision-making, and transparent outcomes. Watch Live Now → play.shiftlayer.ai/room

Subscribe and read the full release here→manifoldlabs.substack.com/p/pressure-mak…

Pressure makes diamonds. This week's Subnet Signal covers: → Bittensor's biggest exit and how the network rebuilt in four days → Why open-source means no one can take the technology when they leave → Locked Stake: measuring subnet owner commitment, verifiable on-chain

We’ve completely redesigned and are thrilled to launch @brainplay_ai. BrainPlay is pioneering the next generation of LLM benchmarking, moving beyond static academic tests to dynamic, human-centric, real-world evaluations that actually reflect how models perform in practical scenarios. Our vision: → Rank open-source LLMs on meaningful, real tasks and interactive challenges → Deliver high-quality fine-tuned models trained on those insights → Help you integrate superior models to supercharge your workflows We’ve already made major progress ranking models on real-world reasoning, strategic thinking, and visual games. Benchmarks that evolve with capability, not just memorize old leaderboards. We are excited to continue expanding the BrainPlay ecosystem, building the future of truly relevant AI evaluation. Follow for updates on @brainplay_ai and learn more at play.shiftlayer.ai

The @Shiftlayer_Ai team has been making great progress. They've been working hard on @brainplay_ai, pioneering the next generation of LLM benchmarking. BrainPlay is moving beyond static academic tests, to dynamic evaluations that actually reflect how models perform in real-world scenarios.

Last week we went to @UCBerkeley, a university which has a history of challenging the status quo and welcoming innovative new technologies. We talked Bittensor, discussed intelligence as a liquid commodity, open systems, and what ownership looks like in a decentralized and incentive-driven network. Huge thank you to to @CalBlockchain for making it happen. We look forward to continuing our University collaborations, and offering students Targon credits to get started building.

Subscribe and read the full release here→ open.substack.com/pub/manifoldla…

Institutional capital is coming to Bittensor through Grayscale. This week's Subnet Signal dives into: → Why GTAO's premium hit +270% and how it compresses to zero → The three shapes staking could take inside a regulated wrapper → Why a tax opinion, not the SEC, determines what happens to the TAO inside

Last week, the Manifold team traveled to San Francisco for Bittensor Commons, where we connected with industry leaders and learned about the latest innovations across the ecosystem. The conference also provided a moment for us to look back at the last year and the milestones we’ve passed with @TargonCompute, including our Series A, collaborations with Nvidia and Intel, and the latest on what’s to come from Targon. A huge thank you to @bt_commons and the entire Bittensor community for your continued support over the years! Hope to see you all again soon in Paris for @proofoftalk!

Today we’re announcing a strategic partnership with @manifoldlabs , the team behind Targon (SN4), one of Bittensor’s leading subnets. As we move toward mainnet, our work with Manifold goes well beyond compute. This is a strategic alignment across incentive design, validator infrastructure, network operations, and ecosystem positioning. Their experience building and scaling Targon is now directly informing how we build our subnet. Minos is bringing genomics to Bittensor. With Manifold's strategic guidance, we intend to set the standard for production-grade genomics AI on the network.

Manifold Labs is proud to announce our strategic advisory engagement with @theminos_ai, providing expert guidance, mentorship, and operational support to accelerate their growth within the Bittensor ecosystem. Minos, the owners and operators of Subnet 107, are building the foundational layer of genomics in an AI world. By building and leveraging synthetic datasets comprised of millions of genomes. Minos aims to improve variant calling algorithms to achieve clinical grade accuracy, and provide a new source of truth for frontier model training and research for genomic identification and discovery. We're very excited to help the Minos team scale sustainably and contribute even more to decentralized AI innovation!

Last week, we released a whitepaper detailing how TVM allows us to run secure workloads on untrusted host machines While this unlocks meaningful revenue opportunities with the enterprise, TVM is only compatible with datacenter hardware (i.e., H100, H200, B200) Today we are announcing targonOS: a hardened OS built upon our TVM work. This will allow for secure ingress/egress of consumer grade GPUs onto the Targon network, while simultaneously expanding the security for our existing TDX VMs By expanding our product offering, we can provide a more robust service to a larger cohort of users, while further lowering the cost of capital for compute owners