Manna Lab

I am delighted to share the exciting news of new publication from our lab doi.org/10.1007/s00018… . Congratulations to @Swarnendu_1997, Qi Gao, and Prof. Dr Elmar Schiebel for this remarkable publication.

Excited to share our latest paper in @JBiolChem! 🌟 @anandushma et al. identify FBXW7 as a critical regulator of centriole duplication, degrading the Plk4-phosphorylated STIL-SAS6 complex. Great effort by the whole team! 👏 jbc.org/article/S0021-…

@msvichu2007 @bio_iisertvm @tvmiiser Thanks @msvichu2007

@MannaLab1 @bio_iisertvm @tvmiiser Congratulations sir!!

🎉 We’re delighted that our PI, Prof. Tapas Manna (School of Biology), has been elected as a **Fellow of the Indian National Science Academy (INSA), New Delhi!** 👏 Big congratulations to Prof. Manna on this achievement — and of course we celebrated with cake! 🎂✨

@Bhagya_Lakshmi_ @bio_iisertvm @tvmiiser Thanks @Bhagya_Lakshmi_

@MannaLab1 @bio_iisertvm @tvmiiser Congratulations Sir!!

@NathSomsubhra @bio_iisertvm @tvmiiser Thank you @NathSomsubhra

@MannaLab1 @bio_iisertvm @tvmiiser Heartiest congratulations,..

@poonam_thakur6 @Pradip_Pb21 @bio_iisertvm @tvmiiser Thank you @poonam_thakur6

@MannaLab1 @Pradip_Pb21 @bio_iisertvm @tvmiiser Big congratulations to @MannaLab1 for this well deserved recognition.

Very excited to welcome and hear from the esteemed speakers in 'Microtubule Network' meeting at CDFD 🎉 🎉 with @GunjanM43894285 #microtubules #centromeres #centrosome #mitosis @DBT_CDFD @KaustuvSanyal @vmdraviam @Sachin_mitosis @almut_kelber @c_swadhin @MannaLab1 @PS_lab

Prof. Tapas K. Manna and PhD student Swarnendu Mukhopadhyay presented their research at the Indo-German Meeting on Cytoskeleton Biology in Health and Diseases held at IISc (June 3–5, 2025). Their talks highlighted new insights into centriole duplication and biogenesis. #MannaLab

Aneuploidy induction mechanisms via the CENP-E kinesin, a chromosome transporter, that is associated with cancer. CENP-E also reqd to maintain interpolar microtubules. Tapas Manna @tvmiiser in #M2T22025

Excited to share that @Swarnendu_1997 and @Delvinpauly won the Best Poster Prizes at the FS-Bio Symposium held at IISER Thiruvananthapuram from Feb 7-9!

Congratulations to the winners of the best poster prize: Delvin, Swarnendu, Hritik, Jeena, Special mention posters: Santosh, Tiyas, and Parnika. Best Flash Talks: Anandita and Kavitha.

Ushma Anand presented her research at ASCB EMBO Cell Bio 2024 (Dec 14-18, San Diego), supported by an EMBO travel grant. Her poster and teaser talk in the “Everything Microtubules & Cell Division” session highlighted FBXW7’s role in regulating STIL and centriole duplication.

Manna lab, during the poster session at 6th International Chromosome Stability meeting, JNCASR, Bengaluru, India

Had an amazing time celebrating Onam in the lab yesterday! 🌸🌿 The vibrant Pookalam, delicious sadya, and great company made it unforgettable. #Onam2024 #LabCelebrations #FestiveVibes #CCD

It's the end of another academic year! 🥂 Cheers to @Bhagya_Lakshmi_, @LiasusanGeorge, @ShebaCheeran, and @msvichu2007 on graduating! 🎓 Your contributions to the lab was invaluable. Best wishes for your future endeavors! 🎉🌟

A huge congratulations to Dr. Bhagya Lakshmi @Bhagya_Lakshmi_ for successfully defending her PhD thesis! 🎉 It was great to have her amidst us doing cool science. Wishing her all the best as she steps into an exciting new chapter at @barisic_lab 🌟

👏🎉 Congratulations Dr Vishnu M Nair on successfully defending your thesis on the role of E3 ubiquitin ligase, FBXW7, in mitotic checkpoint regulation! It was a truly great Journey throughout. #TKMLab

1/4 kinetochores which in turn ensures optimum dynein mediated stripping of CENP-E thus leading to its stabilization at the aligned kinetochores.

Kudos to @Bhagya_Lakshmi_ , all the authors and thanks to collaborators @BenDavidLab, Dr. Raja Paul, Dr. Sarit Agasti for the work published in EMBO reports. The paper sheds light on the crucial role of CKAP5 in stabilizing CENPE at the kinetochore. embopress.org/doi/full/10.10…

Co-depletion of dynein adaptor Spindly along with CKAP5 showed a significant rescue in kinetochore levels of CENP-E. Altogether, our results suggest a mechanism by which CKAP5 regulates stability of kinetochore attached microtubules and maintains optimum PP1 levels at the.....

CKAP5 depletion leads to increased stability of kinetochore attached microtubules and an associated increase in recruitment of protein phosphatase 1 (PP1) to the kinetochores.