Manuel Leonardo Merz

Hot off the press 🔥 In our paper published today in @nchembio, we tackled the challenge of developing orally bioavailable peptides💊 ➡️You can read the full article here (open access🔓): nature.com/articles/s4158… A brief 🧵 1/5

Very pleased to share one of my postdoctoral works from the Heinis lab. Now published in @angew_chem #openaccess #macrocycles onlinelibrary.wiley.com/doi/10.1002/an…

🌟 Excited to share some thrilling news! 🌟 I'll be speaking at the upcoming Next Gen Peptide Formulation & Delivery Summit, where I'll be talking about our efforts in developing orally bioavailable cyclic peptides.💡 Follow this link to find out more: ter.li/mz8akn🚀

Latest paper from the Heinis lab. Solid-phase peptide synthesis in 4 × 384 well-plates to prepare 1,536 peptides per run! Out in J. Pept. Sci! Big congrats to co-first authors Mischa and @EdJWill! @EPFL_CHEM_Tweet onlinelibrary.wiley.com/doi/full/10.10…

Last but not least: A short research briefing can be found here: nature.com/articles/s4158… 5/5 Thanks for staying until the end 👋

What's next❓ We hope to apply this strategy to other disease targets in the future and to further unlock the therapeutic potential of peptides. 🔓💊 4/5

What did we do❓ We developed a method for generating cyclic peptide libraries & identified potent, selective inhibitors that are orally bioavailable in rats. Most importantly, we were able to improve affinity and membrane permeability simultaneously in functional screens. 3/5

Hot off the press 🔥 In our paper published today in @nchembio, we tackled the challenge of developing orally bioavailable peptides💊 ➡️You can read the full article here (open access🔓): nature.com/articles/s4158… A brief 🧵 1/5

First of all: Huge thanks to everyone from the #HeinisLab & @EPFL_en / @EPFL_CHEM_Tweet involved in this project for the great collaboration (@BoLi_Pep, @alexanderln91 & many others) 2/5

How to successfully write a grant proposal. I have worked on >50 grants over the last few years and host workshops about how to write your own. These are my master tips. A 🧵 @openacademics @YTacademics #scicomm #Academittwitter #academicchatter 1/4

🧵A thread to set your GRANT WRITING MINDSET! I review >10 GRANT PROPOSALS/yr, and find consistent mistakes that can be fixed with a quick MINDSET shift: How to think about a proposal Who reviews it The review process @OpenAcademics @PhD_Balance @PhDfriendSana #Academicchatter

So excited to share the first work entirely from our group! Congrats @FurstLab @rariella1 @ReynoldsErinE Thanks @ACSCentSci @CarolynBertozzi @christhechang! pubs.acs.org/doi/abs/10.102…

How many of those have you written? 😅📝 @ButlerKaycie

Can highly recommend this program!

@KatharinaJungo congrats 🎉

For a great explanation of MFCs and a deeper look into some of the work one optimizing this technology, check out this talk from the annual MSI symposium by Dr. Ariel Furst @afurst1 youtu.be/xp1my7Wv7KU?t=3

First paper from the Furst Lab published today in ACS infectious diseases! Congrats Amruta and Ariel! pubs.acs.org/doi/full/10.10…