Bo Li

#Amides Amide Bond Activation: Concepts and Reactions edited by @Szostak_Group, is now online. Check it out for the latest on #amide #bonds. wiley.com/en-us/Amide+Bo…

Late-stage skeletal editing of peptide −SS− bonds through bis-dehydroalanine intermediates provides ready access to chemically unique −CC− carbocycles with enhanced biopharmaceutical properties go.acs.org/2EC NEW #ASAP by Steven Bloom & Samuel Gary @ChemKu

New work out from the Mo Lab in Nature Chemistry, “Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine.” Congratulations Brett, Kenzie, Mo! Paper: rdcu.be/cYE8Y #peptides #proteins #microbiome

We are very excited to share that our paper looking into @amanitin isomers has been published in @NatureComms! Have a look at why we suggest to call the isomer pairs #ansamers here Open access: 👉rdcu.be/cYyOE

Happy to share our study that just published in Nature Communications about the discovery of novel cyclic peptides that modulate the activity of Lys63-linked ubiquitin chains in DNA repair nature.com/articles/s4146…

I’m excited to share our work on the development of bacterial PROTACs acting against Mycobacterium tuberculosis :) Our "homo-BacPROTACs" are able to kill drug-resistant Mtb by inducing the degradation of ClpC1, an essential protein in mycobacteria. doi.org/jgd4

This one brings an exhausted, contented smile. A true pandemic paper, delayed by lab shutdowns, international travel bans, and 'procrastination' in writing due to being head of teaching throughout the pandemic. But it's finally done! Congrats to Ameer and thanks to all.

Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine–Tryptophan Crosslink @J_A_C_S @isciverse #Chemistry #ChemTwitter #scicomm #news #Technology #Tech #NewsBreak #Trending #research #science #AcademicTwitter pubs.acs.org/doi/10.1021/ja…

#Bioinspired #TotalSynthesis of Pyritide A2 through Pyridine Ring Synthesis by Annie R. Hooper, Andraž Oštrek, Ana Milian-Lopez, and David Sarlah @SarlahLab at @ChemistryUIUC in @angew_chem onlinelibrary.wiley.com/doi/10.1002/an…

In recent years, covalent molecules have become increasingly popular among drug developers for their potency and their ability, if designed properly, to bind selectively to their intended targets and shut them down for good. fal.cn/3rqXl

mRNA display makes billions of macrocyclic peptides in one round (🤯) - dramatically impacting drug discovery. @ACSMedChemLett highlights Merck’s PCSK9 inhibitor which is the first clinical candidate from this technology! pubs.acs.org/doi/10.1021/ac…

Advances in covalent drug discovery dlvr.it/SXDmWh

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile @UCSF @UCBerkeley @UCB_Chemistry @kevansf #Chemoselective #Covalent #KRas #SmallMolecule #Probes #Electrophiles pubs.acs.org/doi/10.1021/ja…

Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy pubs.acs.org/doi/10.1021/ja…

#TotalSynthesis of Darobactin A by M. Nesic, D. Ryffel, J. Maturano, M. Shevlin, S. Pollack, D. Gauthier, P. Trigo-Mouriño, L.-K. Zhang, @danithechemist, J. Dunn, @DrLCsquare, N. Patel, D. Petrone @Merck, D. Sarlah @SarlahLab @ChemistryUIUC in @J_A_C_S pubs.acs.org/doi/10.1021/ja…

A new paper from @kevansf and @bignerdzzy identified a strained β-lactone electrophile that covalently targets a KRAS G12 somatic 2 mutation and acylates the mutant serine to suppress oncogenic signaling.

Congrats to Simon Ng, Alex Brueckner, and team for this work just out in J Med Chem that identifies macrocyclic peptide ligands against STUB1 (aka Chip). These peptides serve as important starting points STUB1 inhibitors and/or target protein degraders. pubs.acs.org/doi/10.1021/ac…

Is a third way for manufacturing peptides? Read out recently published review @ACSChemRev Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides pubs.acs.org/doi/10.1021/ac…

Versatile Synthesis of Multivalent Porphyrin-Peptide Conjugates by Direct Porphyrin Construction on Resin (Wong) @hkbaptistu onlinelibrary.wiley.com/doi/10.1002/an…

Property-Driven Development of Passively Permeable Macrocyclic Scaffolds Using Heterocycles (Yudin) @andrei_yudin @GeorgeJSaunders onlinelibrary.wiley.com/doi/10.1002/an…