Maq🧬

@FahadYasin55 @StanfordMed @RNAedit Thanks, Fahad!

@Maq_RNA @StanfordMed @RNAedit Congratulations bro

Excited to announce that I've joined @StanfordMed Department of Genetics as a postdoc in Li lab @RNAedit ! I'll be diving into RNA editing, innate immunity, and aging — quite a range, but ready for the challenge. Looking forward to what's ahead! 🧬

@RNAedit @StanfordMed Thank you, Billy!

@Maq_RNA @StanfordMed Welcome aboard, Maq! I am excited to work with you in this adventure!

Honored to co-author with my previous advisor Zisheng on this review leveraging epitranscriptomic engineering as a next-generation approach to improve crop traits. Thanks Brian @bdgPhD for the invaluable input. A lot of progress has been made — excited to see what’s next!

@Xiaojie_Qiu Congrats! Using now🙂

We are thrilled to share our preprint (tinyurl.com/3mtbtcwu) on PantheonOS, the first evolvable, privacy-preserving multi-agent operating system for automatic genomics discovery. 📄 Preprint: tinyurl.com/3mtbtcwu 🤖 Open-source App (free to all users): app.pantheonos.stanford.edu 🌐 More: pantheonos.stanford.edu PantheonOS unites LLM-powered agents, reinforcement learning, and agentic code evolution to push beyond routine analysis — evolving state-of-the-art algorithms to super-human performance. 🧬 Evolved batch correction (Harmony, Scanorama, BBKNN) and Reinforcement learning or RL agumented algorithms 🧠 RL–augmented gene panel design 🧭 Intelligent routing across 22+ virtual cell foundation models 🧫 Autonomous discovery from newly generated 3D early mouse embryo data 🫀 Integrated human fetal heart multi-omics with 3D whole-heart spatial data From uncovering asymmetric Cer1–Nodal inhibition in early mouse embryos to mapping spatial disease programs in the human heart, PantheonOS demonstrates a future where AI agents don’t just analyze biology — they drive discovery. This is a step toward self-evolving AI systems that accelerate science itself and push human civilization toward the singularity. This work is built over 2 years by an incredible team (Weize @Nanguage who led this project, and also to Erwin, Zhongquan @BAKEZQ, Chris @chriswzou , Zehua @starlitnightly, Yifan @YifanLu2024 , Xuehai, Zhongquan, and Miao, Cinlong's wetlab support and the entire Qiu lab. We are grateful for all our funders and industrial collaborators: @Lenovo @vizgen_inc We are excited to scale this work further and welcome philanthropic, industrial, and venture support. We invite the community (pantheonos.stanford.edu/ecosystem) to contribute, extend, and collectively reimagine the future of automated biological discovery. 🌐 More details below:

Now online! RNA innate immunity constitutes a barrier for interspecies chimerism dlvr.it/TPRj8B

Big congrats!

Thrilled to introduce our minireview in TCB @TrendsCellBio on exploring the "uncharted territory" of NAD cap. Big thanks to great assistance from Dr. Hao at Prof. Xuemei's lab @Xuemei_RNAlab.

A nice talk with ZJUglobal and proud to be a ZJUer! Welcome to the new era of noncanonical RNA cap!

Awesome work! Always looking forward to more underlying implications.

Nature research paper: Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide go.nature.com/44nyQYy

RNA transcripts in bacteria are recorded as DNA modifications using a base editor go.nature.com/3Zdjvbf

@grnfluoresceblg Hi, I wonder is that a published research? HIV infection decrease the NAD capped RNA, what will be the mechanism and the biological significance?

NAD-capped rna found in prokaryotes h eukaryotes. In mammals many snRNAs NAD rna decrease upon hiv infection. Show NAD-U1 less affinity to hiv rna compared to regulare cap.

Last for this session is Hana Cahova on NAD capping and HIV infection #EESRNA