Sharing a thoughtful story from Cedars-Sinai on the discovery process that led to deramiocel for Duchenne cardiomyopathy. It’s been an amazing journey!
cedars-sinai.edu/health-science…
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Eduardo Marban, MD, PhD
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Eduardo Marban, MD, PhD
@MarbanLab
Dr. Eduardo Marban | Executive Director, Smidt Heart Institute @CedarsSinai Views are my own, not institutional policy!
Cedars-Sinai Medical Center Katılım Mayıs 2021
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This is not only a loss to cardiology at large, but also a personal loss. Gene went out of his way to engage me and serve as a mentor over the years, even if at a distance. Our paper, "Training the Clinician Investigator", has some helpful pearls: ahajournals.org/doi/10.1161/CI…
American Heart Association@American_Heart
The American Heart Association mourns the passing of the legendary cardiologist Eugene Braunwald, M.D., widely recognized as one of the most influential figures in the history of cardiovascular medicine. Over seven decades, his work reshaped the understanding and treatment of heart disease, leading many to call him the father of modern cardiology. Braunwald was a lifelong contributor to the American Heart Association, helping advance its research and scientific mission, and was honored with some of the Association’s highest honors for his lasting influence on cardiovascular care and research. His influence extended well beyond his own discoveries, as generations of Association‑supported investigators, clinicians and academic leaders were trained by Braunwald or guided by the clinical trial standards and mentorship models he helped establish. newsroom.heart.org/news/american-…
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Honored to be elected into the AAP yesterday in Chicago
Immense thanks to @WendyPost9 Dr. JoAnn Manson @rblument1 and @CMAlbertEP for your support and guidance across the years!
Roger Blumenthal@rblument1
Congratulations to Dr. Samia Mora -@CiccaroneCenter alumnus - on her induction into the Uber Prestigious Association of American Physicians & her nominator Dr. Wendy Post. Both are also members of ASCI, which also inducted @ChiadiNdumele yesterday. #🥍🐦🫀⛳️⚽️🏈⚾️
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This week’s lab meeting feat. @coralf_reef discussing his work w/James Dawkins & @EugenioCingolan on biological alternatives to ablation for #VT. Much promise to move from tissue destruction to tissue healing as a therapeutic strategy.
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We were pleased to host @kory_lavine of @washumedicine as @SmidtHeart visiting professor. Kory’s cutting edge work on innate immunity is identifying new #therapeutic targets for #heartfailure. @LavineLab
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#journalclub featured Adarsh Balaji @ke_liaoPhD & @TheIbrahimLab each reviewing novel #therapeutic interventions— self-amplifying #mRNA post-MI, “scarless” circular #RNA to improve CAR-T, & “flexomers” for Lewe body dementia & related synocleinopathies. Terrific presentations!
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@CaseyHealthC @SmidtHeart @NIH @rrogerslab @jgoldhaber AI bots got this one wrong— no link whatsoever to UK!
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@MarbanLab @SmidtHeart @NIH @rrogerslab @jgoldhaber Brilliant exosome work, but watching talent we trained flock to Cedars Sinai stings. UK biotech has become a farm for American and Emirati institutions.
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Today’s @SmidtHeart #Research Series featured 2 trainees on our @NIH #T32: Adarsh Balaji, PhD & Jonah Zarrow, PhD on their groundbreaking work to create novel #RNA drugs based on #exosome cargo under the mentorship of @rrogerslab.
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Today’s #labmeeting featured Diana Kitka, mentored by @TheIbrahimLab, on myeloid cells and how they are altered by #exomer TY1 after #cardiac #ischemia. Elegant methodology leading to new insights!
@SmidtHeart
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We were delighted to welcome @SaumyaDas_Lab as @SmidtHeart research seminar speaker. Saumya reviewed his groundbreaking work on #tRNA fragments as regulators of #autophagy and potential therapeutic candidates.
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Informative #labmeeting today by @ginachen_jiahui on biomaterial-based approaches to a major unmet medical need: #adhesions after abdominal #surgery. Definite need for new adjunctive measures to prevent!
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Stimulating @SmidtHeart research seminar today by Prof Na Li of @BaylorMedicine on atrial fibrillation and its relationship to the #inflammasome. 👍👏🙏
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The final version of our @JPhysiol paper "Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics" is out! Big thanks to the editors and reviewers for helpful feedback! physoc.onlinelibrary.wiley.com/doi/10.1113/JP…
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Looking forward to visiting my old hunting grounds @HopkinsMedicine — where I spent 25 years from #oslerpride intern through Chief of Cardiology (@hopkinsheart) before founding @SmidtHeart. I’ll discuss the nonlinear arc from Deramiocel for #Duchenne to #exomers. @TheIbrahimLab
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TY2 is our second #ncRNA #drug in clinical development based on the #CREDO discovery paradigm— this one is amazingly potent and effective in clearing #interstitial #debris! Work supported by @CIRMnews
JCI insight@JCI_insight
This Research Letter offers a creative approach to #sepsis based on a naturally occurring efferocytosis-enhancing RNA doi.org/10.1172/jci.in… Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by @AleCiulloPhD, @Marbanlab, @TheIbrahimlab & team @CedarsSinai. The image shows exposure to TY2 increases E. coli clearance by bone-marrow derived macrophages as indicated by fluorophore as a reporter of efferocytosis (green).
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Eduardo Marban, MD, PhD retweetledi
@AleCiulloPhD @MarbanLab Behind the scenes: Ciullo and team develop an exomer drug based on a naturally occurring RNA and investigate its bioactivity in acute sepsis.
@AleCiulloPhD @TheIbrahimLab @MarbanLab @Kara_tsi @anhhnguyennn9 @Hiroaki_komuro @XMichaelJonesMD @SmidtHeart
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@CaseyHealthC @joshuagoco @TheIbrahimLab Calling the UAE stable is sure proof this comment is AI-generated!
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@MarbanLab @joshuagoco @TheIbrahimLab I worry this TREX1 breakthrough is another we'll lose to funding chaos. Happy travels Josh. The UAE offers the stability and investment this sector desperately needs.
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Today’s lab meeting featured @joshuagoco testing of #TREX1-enhancing #exomer TY1 on chronic #MI in mice. TY1 given 3 weeks post-MI improved function and volumes despite the chronicity of injury— does mitochondrial DNA scavenging underlie MoA? Happy travels Josh!
@TheIbrahimLab
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15 years ago, I urged postdoc @MarkAmin2019 to test allogeneic #CDCs in #mdx mice to see if they ameliorate #Duchenne #cardiomyopathy. Flash forward: #Deramiocel dramatically preserves both heart and skeletal muscle function in #DMD patients as Craig McDonald shows today #MDAorg!
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