Marc Forrest

Our new review on CNVs in neuropsychiatric disorders is now online 💫. Thanks to Current Opinion in Neurobiology for the opportunity to write this. Read below to find out more about genetics and disease mechanisms in #CNVs #16p11 #15q11 #22q11🧵 1/5 doi.org/10.1016/j.conb…

Congrats to @MarcForrest7 , Ph.D., on receiving a 2025 BBRF Young Investigator Grant for innovative mental health research. Read more: bbrfoundation.org/content/brain-…

Akap11 mutations greatly increase risk for #bipolar disorder and #schizophrenia. Not much was known about this gene when we started. Here’s what we learned! biorxiv.org/content/10.110… Thanks to Morgan Sheng, @ajgrange, Yang Ge, Borislav Dejanovic & crew @broadinstitute

Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B. Jessica Christiansen on novel regulatory sites in schizophrenia risk gene TRIO - poster B67. @MarcForrest7 on homeostatic plasticity in 16p11.2 duplication - poster B68.

A Review in @NatRevNeurosci describes our current understanding of the complex genetic architecture of schizophrenia and considers how the genomic findings can be interrogated to boost our understanding of the neurobiology of the disorder. 🔒 go.nature.com/3zZpKY6

Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes dlvr.it/T84fwQ

Northwestern Medicine scientists have been awarded a $17 million grant to study genetic causes of #autism and #schizophrenia, with the aim of developing new drugs to treat the conditions. spr.ly/6019eLusT

Whole brain(!) in vivo gene editing to correct a point mutation in a ASD mice model. Li, Zhang, et al. Nat Neuro nature.com/articles/s4159…

Very good to see this very large study countering strong claims that maternal infection increases risk of autism in offspring. They found no evidence of an association.

Glad to see the psychiatric genetics researchers introducing the practice of adding polygenic score effect sizes in the MAF vs effect size plot x.com/doctorveera/st…

Nice plot visualizing the effect sizes (vs carrier frequency) of common variants, rare variants, CNVs and polygenic score (top vs bottom decile) associated with ADHD. From a new Nat Rev Dis Primer on ADHD by Faraone et al. nature.com/articles/s4157…

I wrote down my rules on how to Science. I hope you find it useful!

Essay from a medical student suffering from bipolar disorder: "It left me wondering if society has the wrong idea [...] Yes, it may enhance aspects of creativity and productivity at times, but that does not detract from the struggle of living with a chronic illness."

The first cellular map of a mammalian brain is here. 🧠✨ Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals astonishing diversity and regional specificity. Dive deeper: alleninstitute.org/scientists-unv… @nature #studyBRAIN #BICCN

New Center for Psychiatric Neuroscience being created at @NUFeinbergMed. Even got mentioned in the new release! 😁

An NIH advisory group announced today that they're recommending the agency boost its minimum #postdoc salary to $70,000, up from the current $56,484. Many postdocs feel "underpaid and overworked," a co-chair said. My latest for @ScienceInsider: science.org/content/articl…

A new review summarizing my current thoughts on the neurobiology of schizophrenia: authors.elsevier.com/a/1iF293Q9h2Ee…

Just a reminder that Cellpose2.0 is a great, free, fast option to quant all kinds of histology from immediate early genes to RNAscope etc. Counted cFos for n=12 mice across n=19 brain regions, totaling over 20k cells in ~2hrs github.com/mouseland/cell…

AI reviewing GWAS literature. Looks pretty cool. May be its time for me to retire. 😅 youtube.com/watch?v=sPiOP_…

Fascinating thread on human genetics as a source of drug targets. TL;DR: — strong human genetic data boosts odds of success for therapeutics — plenty of genetically validated targets still left to be drugged Excited to read the paper in more detail. HT @rplenge

Really nice study of dup15q syndrome, examining developmental and postnatal molecular changes in #autism, using both #organoids and post-mortem brain samples, by @Yonatan_Peretz @velmeshevlab @Kriegsteinlab and colleagues 🧬🧠🧫 biorxiv.org/content/10.110…