Maresca Lab

Proximity-based activation of AURORA A by MPS1 potentiates error correction biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes biorxiv.org/content/10.110…

@aribidopsis Awesome news!

Today, I received the Green Card in mail! One of the most stressful times as an immigrant was going through all the visa status and work permit. It is a great relief!

@benofreedman @XPOTASN @MadPsintist @ncats_nih_gov @US_FDA Congratulations Beno!

9 years ago I crossed coasts to join kidney #organoids with @XPOTASN & @MadPsintist’s #kidneychips. Working together has been a great honor. Excited to co-direct this new @ncats_nih_gov project to obtain @US_FDA’s approval for off-the-shelf disease models. newsroom.uw.edu/news-releases/…

Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!

I am hiring in 2024. Contact me if you'd like to learn about my lab and the NIH

Image shows characterization of cytosolic Spc105 oligomers. McGory et al. @MarescaLab @UMassAmherst uncover a linkage between the disordered kinetochore protein Spc105 and the dynein-targeting RZZ complex. hubs.la/Q02frJnM0 #Mitosis #CellDivision #Cytoskeleton

Multimerization of a disordered #kinetochore protein promotes accurate chromosome segregation by localizing a core #dynein module, say Jessica McGory, Thomas Maresca @MarescaLab and colleagues @UMassAmherst: hubs.la/Q02frL-d0 #Mitosis #CellDivision #Cytoskeleton

McGory et al @MarescaLab @UMassAmherst reveal that multimerization of the disordered #kinetochore protein Spc105 helps recruit a pool of the dynein-targeting RZZ complex to promote accurate chromosome segregation hubs.la/Q02frLw90 #CellDivision #Cytoskeleton #mitosis

Check out the new @marescalab preprint (with @viktzv and Pat Wadsworth). Look at that dynein go! biorxiv.org/content/10.110…

Very happy and proud to share the work PhD student Joana Lima @i3S_UPorto “A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly”, now online. biorxiv.org/content/10.110…

Check out our new preprint: An intrinsically disordered kinetochore protein coordinates mechanical regulation of chromosome segregation by dynein biorxiv.org/content/10.110…

@MCDuncanLab @CNS_UMass Thanks Mara!

Congrats to #UMass #Biology Assoc. Prof. & Dir. of the Molecular & Cellular Biology Program Tom Maresca @MarescaLab for being awarded a Fulbright Scholar Award! umass.science/3xZzSwx

The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit biorxiv.org/content/10.110…

Spindle assembly in Xenopus egg extracts! Videos were taken while working late into the night at @MBLScience with Aaron Groen and @GatlinLab. The montage is from our (@viktzv) recent retrospective in @MBoCjournal on a seminal paper by @rebeccaheald. ow.ly/GTsW50HHlPY

A celebration of the 25th anniversary of chromatin-mediated spindle assembly | Molecular Biology of the Cell molbiolcell.org/doi/full/10.10…

@r_racicot This made my day, week, month, and beyond. Thanks @r_racicot!

Wish we could think seriously about the authors suggestion of an A/A-/Pass/Fail model, which is effectively the med school grading scheme.

If every school would do this, kids would learn so much more. slate.com/human-interest… via @slate