Mark Damante, MD

We are thrilled to announce our 2026 match class! Welcome to Ohio State Neurosurgery! #matchday2026

@MatthieuDWeber did an amazing job @NASBSorg presenting our @NeurosurgeryOSU strategy for large anterior fossa #meningiomas @OSUCCC_James

We are excited to be one of the host institutions for the new Expanse program for US medical students without a home neurosurgery program! Apply now for the chance to spend the summer learning essential neuroscience techniques!: neurosurgery.ucsf.edu/expanse-program

Robotic-assisted placement of convective delivery cannulas enhances access to previously difficult-to-reach deep brain structures, like the cerebellar dentate nucleus, while maintaining precision and improving efficiency. #Neurosurgery #GeneTherapy journals.lww.com/onsonline/full…

@NeurosurgeryOSU @OSUGeneTherapy #Neurosurgery #GeneTherapy #Innovation

Just out in @NeurosurgeryCNS, a study led by @MarkD_Jr (@NeurosurgeryOSU), demonstrates the feasibility, effectiveness and efficiency of robot-assisted placement of convection-enhanced delivery cannulas in the brain. This advance can streamline and enhance direct infusion of therapeutics to the brain. #neurosurgery #CED #GeneTherapy @OhioStateMed @OSUWexMed @Solid_Bio @CNS_Update @OSUGeneTherapy journals.lww.com/onsonline/abst…

Gene therapy research, by ⁦@NeurosurgeryOSU⁩ neurosurgeons, ⁦@RussellLonser⁩ and Brad Elder, M.D., offer insights into tumors and neurologic disorders. #neurosurgery #GeneTherapy ⁦@OhioStateMed⁩ ⁦@OSUWexMed⁩ ⁦@OSUCCC_James⁩ thelantern.com/2026/02/advanc…

#OnlineFirst: Direct image-guided convective perfusion of the bilateral thalami for gene therapy in frontotemporal dementia: technical note. thejns.org/view/journals/…

🧬This is an important milestone for the #FriedreichsAtaxia community. #RareDiseaseResearch

Yesterday, Solid Biosciences shared an important update with the Friedreich’s ataxia community. The first participant has been dosed in the Phase 1b FALCON trial evaluating SGT-212, our novel, investigational dual-route administration gene therapy for the treatment of FA. We are deeply grateful to the FA community, @CureFA_org, our clinical partners, and the patients and families whose trust and participation make this work possible. Your partnership continues to guide our mission to advance meaningful therapies for people living with FA. Read the full community letter here: solidbio.com/letter-to-the-… #FriedreichsAtaxia #FACommunity #RareDiseaseResearch

Mark Damante, M.D., (@MarkD_Jr) and colleagues (@NeurosurgeryOSU and @OhioStateRadOnc ) show (@JNeurooncol) that for intermediate-sized motor-cortex #metastases, patients benefit from surgical resection plus #SRS compared to SRS alone. These foundational findings demonstrate the critical role that resection plays in optimal patient outcome for metastatic deposits in functional areas. link.springer.com/article/10.100… #NeuroOncology #neurosurgery #BrainMetastasis #RadOnc #MotorCortex #ClinicalOutcomes #OncologyResearch #XMed @OhioStateMed @OSUWexMed @OSUCCC_James @joshuapalmermd

Real-time MR-imaging demonstrates bilateral thalamic convective infusions for gene therapy for fronto-temporal dementia (@AviadoBio). MR-guidance allows for continuous monitoring of vector distribution during delivery. We describe this technique in @TheJNS (thejns.org/view/journals/…). #GeneTherapy #neurosurgery #FTD #neuroscience #CED #neurodegeneration #dementia @NeurosurgeryOSU @OSUWexMed @OSUGeneTherapy

Real-time MR-guided intrathalamic convective delivery for gene therapy for frontal temporal dementia (@AviadoBio) reveals predictable scaling, high containment and lack of leak back. These features establish the thalamus as an excellent convective delivery conduit for gene therapy. thejns.org/view/journals/… #neurosurgery #FTD #GeneTherapy #Neuroscience #CED @TheJNS @AANSNeuro @NeurosurgeryOSU @OSUGeneTherapy @OhioStateMed @OSUWexMed

Just out is the @forbes, 'Five Medical Breakthroughs of 2025'. Four of the breakthroughs are gene therapies for enzyme disorders, deafness, Huntington's disease and heart disease. #Huntingtons #GeneTherapy #CED #neuroscience forbes.com/sites/juergene…

Excited to share this recent publication in JNO on a relevant topic. Case-matched analysis demonstrated that resection+SRS/SRT resulted in superior strength improvement and motor outcome compared to radiation alone for 1-3cm motor cortex metastases.doi: 10.1007/s11060-025-05378-2

Brad Elder, M.D., presenting early clinical trial findings on a first-in-human restorative gene therapy for #Alzheimer’s disease at the 2025 American Academy of Neurological Surgery Meeting (#AAcNS). A potential paradigm shift in treatment. @NeurosurgeryOSU @OhioStateMed @OSUGeneTherapy @OSUWexMed #genetherapy #Athens #Greece

Thank you to @adunka, Professor of Otolaryngology @OhioStateENT, for the fantastic talk on the management of vestibular schwannomas in the setting of Neurofibromatosis type 2! Our skull base team thrives due to our close working relationship with our ENT colleagues!

Medical student education is very important! Early exposure to the different subspecialties helps students choose the right path for them. Here is @vicschu44 presenting on what a career in neurosurgery looks like to our @OhioStateMed 1st year medical students

Very excited to announce our recent complement increase! We are now officially 4 residents per year for a total complement of 28 residents. This is a reflection of our entire departments hard work and will ensure our residency program continues to be a top program!