Marqusee Lab

Check out Naomi's paper examining domain coupling in mGlu receptors on bioRxiv! A fun collaboration with the @IsacoffLab and also featuring great work from our undergraduate researcher Sam! biorxiv.org/content/10.110…

Check it out and let us know what you think! We are really excited by the combination of HDX-MS with eVLPs as it provides an opportunity to more easily study viral fusion proteins and other membrane proteins in native-like environments with HDX-MS. 7/7

D614G shifts the equilibrium to favor the prefusion conformation while the S2' site stays disordered. This study provides, to our knowledge, the first molecular explanation for the dual evolutionary advantages of furin cleavage and D614G. 6/7

Check out Sophie's new preprint on bioRxiv in collaboration with Magnus Hoffmann's lab where we conduct HDX-MS on SARS-CoV-2 spike proteins displayed on eVLPs to understand the dynamics of natural and engineered variants. 1/7 biorxiv.org/content/10.110…

Super cool work by twitterless Naomi and crew looking at domain coupling in mGlu receptors. @MarquseeLab @IsacoffLab Domain coupling in activation of a family C GPCR biorxiv.org/content/10.110…

Big congratulations to PhD student Thea K Schulze from our PRISM centre on being awarded the elite research travel grant by the Minister for Higher Education and Science, Christina Egelund, to support a stay in the @MarquseeLab at Berkeley to study protein variant effects 💪🧬💻

.@NRDall's paper is up on bioRxiv! Using high-throughput in vivo studies and biophysical in vitro assays (CD and HDX/MS), we show how circular permutation affects the expression of HaloTag in different cell environments, and how CP impacts protein stability and folding pathways

It’s out! Via hydrogen deuterium exchange, biochemistry, and cryo-EM, we (Walter lab, @MarquseeLab et al) discovered the allosteric mechanism controlling activity of the core Integrated Stress Response (ISR) regulator eIF2B. 1/10 nature.com/articles/s4158…

Happy to be a part of such a cool story! Structural & dynamic characterization of mGluR intermediate states. Congratulations to Kaavya, @haoqing_wang and all authors. Another productive collaboration with @IsacoffLab & @MarquseeLab!

Amir will present his work on cotranslational folding of the SARS CoV-2 RBD at poster board 15AB. Check out his abstract (#328) and give him a visit!

Susan and @amir_bitran are in Boston for the Protein Society! Catch Susan's plenary talk on Thursday morning, and check out Amir's poster on Saturday evening.

This was a fun collaboration with Mike Harms, @MattSternke, and @superdougb

See Charlotte's new manuscript on bioRxiv

Congratulations to our grad student Darren Kahan on being awarded the @advlightsource Doctoral Fellowship in Residence! He will be working with Dr. Corie Ralston’s lab at the @molecularfndry

Secondary Structure Detection Through Direct Nanopore RNA Sequencing biorxiv.org/cgi/content/sh… #biorxiv_biophys

Chemist Susan Marqusee takes leading role at National Science Foundation news.berkeley.edu/2023/05/16/che…