Nicholas Marston

#SimPub #ACC26 In CCTA substudy of Essence-TIMI 73b (RCT of olezarsen vs. placebo in patients with hypertriglyceridemia), no difference in non calcified, coronary plaque volu... @marstonMD @maciejbanach @AndreZimerman @michael_t_lu @BrianBergmark @BudoffMd ahajrnls.org/4m4ZwHK

@kaulcsmc Pts w/ a single 50-70% stenosis of a coronary or carotid artery did not meet criteria for "qualifying" athero, so these patients are in high-risk DM group in NEJM paper But in this analysis of pts without known "significant" athero, we did not want these 50-70% stenoses included

@marstonMD Can you help explain why numbers in JAMA (1849 vs 1806) & NEJM (2009 vs 1992) are different for high-risk diabetes without qualifying atherosclerosis in VESALIUS-CV? Which outcome best differentiates any qualifying atherosclerosis from high-risk DM w/o AS?

A great team effort as always, and I especially enjoyed the collaboration with friend, colleague, and EC expert @Dr_RajatGupta on this one. @KamanuFred @TIMIStudyGroup

Link to paper here: nature.com/articles/s4159…

Now out in @NatureMedicine, we developed an Endothelial Cell PRS for CAD that: 1) Quantifies a currently immeasurable axis of CAD risk 2) Identifies individuals who are LDL-sensitive 3) Establishes which Pts will have greatest CV benefit from early & aggressive lipid lowering

A big thanks to @dan_soffer for leading this effort, it was fun to collaborate with such a great team! @CBallantyneMD @jpenamd @SethShayMartin @ThanassoulisMD @carolkirkpat3 @giorgio_melloni @nationallipid @LipidJournal @TIMIStudyGroup

To summarize, apoB is a precise, accurate, and well-validated measure that provides information not available on standard lipid panels Incorporation of apoB into clinical practice identifies patients at higher CV risk than appreciated who may warrant intensification of therapy

Honored to be a part of the @NationalLipid Association's Expert Clinical Consensus on the Role of ApoB in the Clinical Management of Cardiovascular Risk in Adults. When should we be checking apoB? How low should we go? See link and thread below... lipidjournal.com/article/S1933-…

Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association - Journal of Clinical Lipidology @nationallipid lipidjournal.com/article/S1933-…