André Zimerman

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André Zimerman

André Zimerman

@AndreZimerman

Head of Clinical Trials, @hospitalmoinhos 🇧🇷 | Professor, PG Cardiology, @ufrgsnoticias 🇧🇷 | Fellowship, @TIMIStudyGroup 🇺🇸 | Lipids, Trials, Cardiology

🇧🇷 Porto Alegre, Brazil Katılım Mayıs 2016
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André Zimerman
André Zimerman@AndreZimerman·
Today, I had the honor to present PhysioSync-HF as a Late-Breaking Clinical Trial at #ESCCongress. Key message: In HFrEF and LBBB, conduction system pacing was *inferior* to biventricular pacing for a composite of death, HF events, and LVEF change at 12 months.
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André Zimerman
André Zimerman@AndreZimerman·
@drjohnm We tried our best to encompass risk stratification and LDL-C targets into a one-stop figure in the 2025 Brazilian guidelines. While categories could be improved, IMO this is a more helpful format for quick decision-making, as is the flowchart. See here: #toc" target="_blank" rel="nofollow noopener">abccardiol.org/wp-content/plu…
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John Mandrola, MD
John Mandrola, MD@drjohnm·
Lipid guidelines contains 14 management flow charts How is a gen cardiologist or primary care doc supposed to be guided by such a document? Should be 3-4: prim prevention, sec prevention, diabetes and maybe special circumstances (FH or TG > 300) It's not that complicated
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JAMA Cardiology
JAMA Cardiology@JAMACardio·
In patients with #HeartFailure and #LBBB, conduction system pacing (#CSP) was inferior to biventricular pacing (#BiVP) for a composite of death, heart failure events, and LVEF change at 12 months. ja.ma/3PgczJP
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André Zimerman
André Zimerman@AndreZimerman·
Proud to see PhysioSync-HF published in @JAMACardio. In patients with HFrEF and LBBB, conduction system pacing was inferior to biventricular pacing for a composite of death, HF events, and LVEF change at 12 months. Let us know your thoughts: jamanetwork.com/journals/jamac…
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JAMA Cardiology
JAMA Cardiology@JAMACardio·
Small-interfering RNA olpasiran reduced lipoprotein(a)–apolipoprotein B particles by >95% with minimal rise in non–Lp(a)-apoB, lowering total apoB concentration in patients with cardiovascular disease. ja.ma/49iZoiR
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André Zimerman
André Zimerman@AndreZimerman·
These findings suggest that, with olpasiran, apoB particles normally destined to form Lp(a) are either not secreted into circulation or more efficiently cleared, providing context for interpreting results of ongoing trials of Lp(a)-lowering agents. Link: jamanetwork.com/journals/jamac…
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André Zimerman
André Zimerman@AndreZimerman·
How do Lp(a)-lowering agents affect atherogenic lipoproteins more broadly? In our @JAMACardio study, we show that olpasiran, an siRNA targeting apo(a), reduced Lp(a) in >95% without increasing non-Lp(a) particles. apoB was ultimately reduced by ~18%. @TIMIStudyGroup
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José de Alencar
José de Alencar@josenalencar·
It was the FTT that, in 1994, grouped thrombolysis studies in myocardial infarction and concluded: Only patients with ST-elevation benefit from thrombolysis. This shaped the next three decades of research progress. Even the evolution of this treatment, angioplasty, was born within this paradigm. But… If a simple methodological choice had been different, the FTT’s result could have been: patients without ST-elevation also benefit from thrombolysis in myocardial infarction. That’s what we demonstrated in this meta-analysis. openheart.bmj.com/content/12/2/e…
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JAMA Cardiology
JAMA Cardiology@JAMACardio·
Small-interfering RNA olpasiran reduced lipoprotein(a)–apolipoprotein B particles by >95% with minimal rise in non–Lp(a)-apoB, lowering total apoB concentration in patients with cardiovascular disease. ja.ma/4qqkClo
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André Zimerman
André Zimerman@AndreZimerman·
I had a great discussion with @DrJMarine on the PhysioSync-HF trial, our (unexpected) findings, and what they mean for the field. Check out our @ACCinTouch podcast episode on Spotify: open.spotify.com/episode/1flNth…
American College of Cardiology@ACCinTouch

The PhysioSync-HF trial investigates conduction system pacing as a potentially more effective & affordable alternative to traditional cardiac resynchronization therapy. Tune into #ACCEL Lite episode for more insights ➡️ bit.ly/4qxh6pp @DrJMarine @AndreZimerman #CardioX

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André Zimerman
André Zimerman@AndreZimerman·
@KostekMilan @VKutyifa We’ll have additional analyses in the primary publication and papers to follow. Agree these will be critical to better interpret our findings in the context of prior trials.
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Joseph Marine
Joseph Marine@DrJMarine·
Greatly enjoyed speaking with @AndreZimerman about his trial results reported at ESC.25. Surprisingly, CSP inferior to conventional CRT in this HFrEF population. Listen to learn more! @ACCinTouch @a_l_bailey ACCEL Lite: PhysioSync-HF: Conduction System vs. Biventricular Pacing in Cardiac Resynchronization in HFrEF - American College of Cardiology acc.org/Latest-in-Card…
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Heart Rhythm TV
Heart Rhythm TV@HeartRhythmTV·
🚨 BREAKING: ESC 2025 Spotlight! #HRStv host @melchami99, sits down with @AndreZimerman, and @Davilandre to break down the PhysioSync-HF trial, presented at ESC Congress 2025 in Madrid. This multicenter study compares conduction system pacing vs biventricular resynchronization in patients with heart failure and left bundle branch block. See the full interview here #EPeeps ➡️ bit.ly/41PF2d3 #ESC2025 #HeartFailure #Cardiology #EP
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Filipe A Moura, MD, PhD
Filipe A Moura, MD, PhD@FilipeAMoura·
Painstaking , careful work from everyone involved. So much effort from the patients, ARO, CRO, and sponsor to get here. It gives a sense of pride being part of the team. Can’t wait for the severe HTG population data, where there will be more immediate impact to patients’ lives.
André Zimerman@AndreZimerman

In patients with TGs >150 mg/dL, apoC-III inhibitor olezarsen reduced TGs by *60%*. Also lower: apoB (↓15%), non-HDL-C (↓22%), and remnant chol (↓68%). The CTA analysis will help clarify the potential CV benefit. Proud to be a part of this team. Now published in the @NEJM.

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Tiago Zimerman
Tiago Zimerman@tiagozimerman·
Officially starting my Fellowship in Biomechanics at @MOR_Docs in Chicago — one of the world’s leading centers for orthopedic research. It is a great honor and an immeasurable privilege to have been selected by RUSH and IBTS to represent Brazil in this one-year program.
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NEJM
NEJM@NEJM·
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia (Essence–TIMI 73b phase 3 trial) nej.md/4mws7Vt #ESCCongress | @escardio
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