as research briefing: A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses doi.org/10.1038/s41591…
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Mathias Jucker
233 posts
Mathias Jucker
@MathiasJucker
Biomedical Researcher Professor @Uni_Tue and @DZNE_en
Tübingen 🇩🇪 & Zürich 🇨🇭 Katılım Ocak 2017
67 Takip Edilen971 Takipçiler
non-specificity for disease, but specificity regarding mechanism? - pTau elevation in blood as a cellular stress response to the deposition of amyloid
Alzforum@alzforum
A positive blood tests for #alzheimersdisease might indicate systemic amyloidosis instead, suggesting clinicians should be cautious when interpreting results. @uni_tue ow.ly/xJ5h50YtUGk
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Mathias Jucker retweetledi
Elevated serum pTau levels are not specific to Alzheimer´s disease and may also serve as diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies @MathiasJucker nature.com/articles/s4159…
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@EricTopol yes, non-specificity for disease, but perhaps specificity regarding mechanism: pTau elevation as a cellular response to the deposition of (any) amyloid
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The blood neuromarkers p-tau181 and p-tau217 that can predict and diagnose Alzheimer's disease are also abnormal in certain types of amyloidosis, indicating both some non-specificity and potential help in diagnosis of these conditions
nature.com/articles/s4159…
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@louisanicola_ @EricTopol ...this overlap could actually be informative, because abnormal p-tau in these patients may reflect shared amyloid related pathophysiology affecting neuronal integrity...very true!!
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It highlights an important limitation of p-tau181 and p-tau217 as Alzheimer’s biomarkers, since tau phosphorylation can also increase with systemic protein misfolding and neuronal stress seen in amyloidosis. At the same time, this overlap could actually be informative, because abnormal p-tau in these patients may reflect shared amyloid related pathophysiology affecting neuronal integrity.
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Alzheimer’s Blood Marker Shows Promise for Heart and Kidney Disease Detection bioengineer.org/alzheimers-blo…
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Blood marker for Alzheimer’s may also be useful in heart and kidney diseases, via @EurekAlert! @dzne_en eurekalert.org/news-releases/…
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it is out! Elevated blood p-tau 181 and 217 levels are not specific to Alzheimer disease and may also serve as a diagnostic tool of ATTR and AL amyloidosis! #alzheimer #biomarker. Wonderful collaboration with 3 European amyloid centers.
@NatureMedicine doi.org/10.1038/s41591…
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Blood #neurofilament (NfL) could serve as a cross-species biomarker for #aging interventions and #mortality prediction | PLOS Biology plos.io/46iNxiX. -- To better understand mortality predition across an even wider range of species, we are now looking for more samples!
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Neurofilament Light (NfL) may serve as a cross-species blood biomarker for assessing ageing interventions and predicting mortality. It was great fun to measure NfL in all these speceis, even in a crocodile!
Mathias Jucker@MathiasJucker
Age-related increase in neurofilament light in blood among mammalian species | PLOS Biology @uni_tue @AgingBiology dx.plos.org/10.1371/journa…
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Age-related increase in neurofilament light in blood among mammalian species | PLOS Biology @uni_tue @AgingBiology dx.plos.org/10.1371/journa…
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We discovered these astrocytic inclusion >25 y ago (DOI: 10.1126/science.1542796); Very satisfying to finally see the genetic linkage. Great work. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus: Cell Systems cell.com/cell-systems/f…
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Mathias Jucker retweetledi
Ageing promotes microglial accumulation of slow-degrading synaptic proteins @Nature
nature.com/articles/s4158…
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Mathias Jucker retweetledi
Dozens of people are feared dead and around 100 others seriously injured after a large fire broke out in a bar in the Swiss ski resort of Crans-Montana. ↩️
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Vasiliki @Vasiliki_Panag made the cover of the December issue cell.com/cell-reports/i…
Mathias Jucker@MathiasJucker
Human-mouse chimeric cultures to study microglia and amyloid pathology; Novel and exciting approach with lots of potential. Congratulations to @Vasiliki_Panag! @uni_tue, Cell Reports cell.com/cell-reports/f…
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Human-mouse chimeric cultures to study microglia and amyloid pathology; Novel and exciting approach with lots of potential. Congratulations to @Vasiliki_Panag! @uni_tue, Cell Reports cell.com/cell-reports/f…
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I worked in the lab next to his department when he generated the Prp ko mouse. He was an incredible scientist.
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Mathias Jucker retweetledi
$NVO oral semaglutide EVOKE studies in Alzheimer's fail.
globenewswire.com/news-release/2…
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