Matthew Ho

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Matthew Ho

Matthew Ho

@MatthewHoMD

@pennmedicine Heme/Onc Fellow via @UCDmedicine; @thebianchilab; @mayoMN_imres

Philadelphia, PA Katılım Temmuz 2020
929 Takip Edilen19.7K Takipçiler
Matthew Ho retweetledi
Rahul Banerjee, MD, FACP
Rahul Banerjee, MD, FACP@RahulBanerjeeMD·
We talk about bsAb revolution coming across the field of oncology - now more of it in classical hematology as well! Letter in big @TheLancet: Time-limited teclistamab in dara-refractory ITP with basically instant platelet normalization 👏 #MMsb bsAbs to the rescue!
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Matthew Ho
Matthew Ho@MatthewHoMD·
@Abeykyahaiyaar @TrackYourHeart It is. Look at the green box for the goal time - < 90 min if transported to PCI-capable facility - < 120 min if transported to non-PCI-capable facility before transfer to PCI-capable one > 120: fibrinolysis + transfer to PCI-capability.
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Matthew Ho
Matthew Ho@MatthewHoMD·
@TheBianchiLab Thank you so much Giada! I got my start in MM research because of you and will always be grateful for the time and effort you spent mentoring me, and for all the help and guidance you continue to provide.
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Matthew Ho
Matthew Ho@MatthewHoMD·
@RahulBanerjeeMD @NatureMedicine Thanks for sharing Dr Banerjee! Re point 2: we did not necessarily observe CD4-specific activity in maraviroc. Maraviroc inhibited BCMA-CART proliferation in vitro (both CD4 and CD8 subsets) without affecting cytotoxicity. @paruzzol is working on validating this in vivo!
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Rahul Banerjee, MD, FACP
Rahul Banerjee, MD, FACP@RahulBanerjeeMD·
Felt like I was reading a suspense novel! Tour de force @NatureMedicine by Penn group re: MNTs, IEC-EC, etc after BCMA CAR-T #MMsm. 1️⃣ Peak ALC matters, but so does CD4 predominance 2️⃣ Maraviroc (HIV Rx) blocked CD4+ driven processes (pre-clinical)! #downwithdex #trymaravirocinstead? [Not yet, but will be fascinating to see more data!]
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Ruella Lab@RuellaLab

Excited to share our new paper in @NatureMedicine uncovering the role of CD4⁺ CAR T cells in CirAEs after BCMA CAR T therapy. @MatthewHoMD @paruzzol @jh_noll @JoeFraietta @MarcoRuella @CohenAd_MMdoc @PennMedicine @PennCancer nature.com/articles/s4159…

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Sanjeev Sethi
Sanjeev Sethi@SethiRenalPath·
Simple concept of GN. It’s all about location! 1. Subendothelial deposits/injury by Ig, immune-complexes, complement, other mechanism leads to influx of leukocytes= inflammation=GN 2. Subepithelial deposits/injury= protected by GBM & endothelial cells=no inflammation=No GN. 1/3
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Matthew Ho
Matthew Ho@MatthewHoMD·
@WilliamAird4 A I think. Normal bilirubin, elevated urobilinogen. Bilirubin broken down in colon to urobilinogen, reabsorbed and filtered by kidneys. Hemolysis results in elevated bilirubin and therefore elevated urobilinogen.
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William Aird
William Aird@WilliamAird4·
Which urinalysis is most consistent with hemolysis?
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Matthew Ho retweetledi
William Aird
William Aird@WilliamAird4·
1/6 TPE-FREE MANAGEMENT OF IMMUNE TTP (iTTP) Retrospective study from Austria and Germany ADAMTS13 activity at baseline <10% in all patients Treatment group (TPE-free): 42 acute iTTP episodes in 41 patients received TPE-free management with caplacizumab + steroids +/- Ritux
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Nico Gagelmann
Nico Gagelmann@NicoGagelmann·
Patient with rash, joint pain and severe anemia. Diagnosis?
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Adam Rodman
Adam Rodman@AdamRodmanMD·
Our first RCT on using an LLM on diagnostic reasoning is out! And the results are 🔥🌶️... adding ChatGPT did NOT improve diagnostic accuracy or reasoning, and the AI alone outperformed ALL the humans. What does this mean? A 🧵⬇️ x.com/EricTopol/stat…
Eric Topol@EricTopol

A small randomized trial of generative #AI for diagnosis again (as seen in a few previous studies) shows higher performance for #AI than physicians + AI. May indicate that physicians need to be trained on how to incorporate AI. #google_vignette" target="_blank" rel="nofollow noopener">jamanetwork.com/journals/jaman…

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Laura Heacock, MD
Laura Heacock, MD@heacockmd·
1/ Challenge accepted. I have run a series of breast mammograms (x-rays), ultrasounds and MRIs through versions of GPT4 and posted the results here previously. Even though it's data contamination to repost images I already used on X, it's an easy bench mark. So how did Grok do on breast radiology? A little better than GPT4v, but not a single diagnosis correct. 👇
Elon Musk@elonmusk

Try submitting x-ray, PET, MRI or other medical images to Grok for analysis. This is still early stage, but it is already quite accurate and will become extremely good. Let us know where Grok gets it right or needs work.

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Matthew Ho
Matthew Ho@MatthewHoMD·
Great reminder that Na delivery to distal tubules and aldosterone needed for kaliuresis. - diuretics (including caffeine) increase Na delivery to distal tubules —> k loss - hypovolemia decreases Na delivery to distal tubules —> reduction in K excretion
Trisha Laxamana MD ❄️🗽🇵🇭@NephroloTrish

Hypokalemia #Nephpearls and the most interesting case I have ever heard of — Rhabdomyolysis from Caffeine (Coffee/Cola)-Induced Hypokalemia‼️ by @VelezNephHepato @OchsnerNephro @ASNKidney #KidneyWk ☕️ @NYUnephro fellows discussing how much caffeine we’ve taken for exams! LOL!

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Matthew Ho retweetledi
Tiffany Caza
Tiffany Caza@Tiff_Caza·
Pseudo-AKI - some drugs cause an increase in creatinine due to decreased creatinine secretion. Cystatin C will be normal. #KidneyWk
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Matthew Ho
Matthew Ho@MatthewHoMD·
@Syed2192 If perfusing (warm, good UOP, no AMS), would trial rate control, which may improve BP. If underlying rEF, wouldn’t use NDHP CCB. Consider adding dig for inotropy.
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Syed@Syed2192·
@MatthewHoMD 60 M HR 165 BP 90/60 Patient otherwise stable can we consider IV BB / CCB to allow enough diastole and help with EF or treat it as AF With adverse features?
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Matthew Ho
Matthew Ho@MatthewHoMD·
Approach to Atrial Fibrillation (Rate vs Rhythm Control) Ref: uptodate, AHA 2023, Mayo IM board review course (Dr Abhishek Deshmukh)
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Keşfet

@TheLancet @Abeykyahaiyaar @TrackYourHeart @TheBianchiLab @RahulBanerjeeMD @NatureMedicine @paruzzol @ManniMD1