Max Fürst (find me as @maxfus in BS)

92 posts

Max Fürst (find me as @maxfus in BS)

Max Fürst (find me as @maxfus in BS)

@MaxFus

Assistant Professor @univgroningen | Biochemist, Protein Engineer, 'Would-be designer' (F. Arnold) | same handle on BluSk

Groningen Katılım Nisan 2011
338 Takip Edilen328 Takipçiler
Max Fürst (find me as @maxfus in BS) retweetledi
The Lonely Pipette
The Lonely Pipette@LonelyPipette·
Wow! There is a real X leak for Bluesky. Are you there? Here is our profile, come say hi: bsky.app/profile/lonely…
Philoxime 🦋 philoxime.bsky.social@philoxime

Enfin ! Xitter est en train de s'effondrer. La plateforme avait déjà perdu 20-30% de ses utilisateurs en 1 an, et c'était AVANT la vague dûe aux élections US 😳 Et euh... y a des rumeurs de fusion avec Truth Social 😬 Pendant ce temps, sur Bluesky : 🚀

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Kresten Lindorff-Larsen
Kresten Lindorff-Larsen@LindorffLarsen·
There’s a place where the sky is blue (and with increasingly many structural biologists and biophysicists)
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Sebastian Wenk
Sebastian Wenk@SebWenk·
🚨 Job alert 🚨 Please retweet 🚨
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Adaptyv Bio
Adaptyv Bio@adaptyvbio·
The Protein Design Competition results are in! 🧬 200 designs tested in our lab 🌍 90 protein designers from around the world 💎 5 novel binders found 🎯 2.5% hit rate (vs 0.01% on previous EGFR work) 1st place: @MartinPacesa & Lennart Nickel 2nd place: @khRRustamov 3rd place: Adrian Tripp (@tugraz)
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Nico Claassens
Nico Claassens@NicoC_MicSynBio·
A recent preprint from our lab about MOSAIC: a very easy protocol to make (short) mutations or libraries in plasmids much easier (no PCR, or assembly cloning needed), just electroporation with oligos! Probably useful for many in the field biorxiv.org/content/10.110… spread the word!
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Zakir Tnimov
Zakir Tnimov@zakir_tnimov·
Hey, #synbio people. Wes Robertson, A good friend of mine and a great scientist is starting his lab @MRC_LMB This is a unique opportunity to have an impact in #synthetic_genomics and work under leadership of talented and ambitious PI. shorturl.at/mnvw9
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Alex Taylor
Alex Taylor@Taylor_Lab_KCL·
4-year studentship available in my lab at @kclchemistry working at the interface of fundamental synthetic biology and therapeutic biotechnology development - come & join me in the XNA world! Please RT findaphd.com/phds/project/c…
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Luke Weston
Luke Weston@lukeweston·
A feeding electric eel can cause transfection of plasmids from the surrounding environment into nearby organisms - natural, eel induced, electroporation. peerj.com/articles/16596/
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Max Fürst (find me as @maxfus in BS)
Max Fürst (find me as @maxfus in BS)@MaxFus·
@PhilHolliger Repurposing an NGS platform, we performed in situ IVT and ribosome display to probe the function of millions of protein (incl. AB) variants with known seq. A ML language model finetuned with these huge datasets then successfully classified the function of unknown sequences 🤯
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Max Fürst (find me as @maxfus in BS)
Max Fürst (find me as @maxfus in BS)@MaxFus·
Really excited to share this work of my postdoc lab @PhilHolliger in which I was fortunate to make a small contribution to. nature.com/articles/s4155… Lead by the incredible Ben Porebski, this work describes an ingenious way to collect massive protein sequence-function datasets.
Phil Holliger@PhilHolliger

New paper from my group out in twitter.com/natBME. Outstanding work by Ben Porebski and great collaboration with twitter.com/AstraZeneca. We describe a new high-throughput strategy for biomolecular discovery, which we call deep screening.

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Siewert-Jan Marrink
Siewert-Jan Marrink@CG_Martini·
Assistant/Associate Professor Position on Computer-Aided Drug Design open in Groningen ! rug.nl/about-ug/work-…
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James Attwater
James Attwater@DrJamesAttwater·
PDRA opportunity in our group @UCLChemistry to develop & characterise ribozymes that harness primordial chemistries. 28 months, funded by BBSRC & Royal Society; org chem or mol bio background. Apply by 7th August: tinyurl.com/4bhhf2v2
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Daan C. Swarts
Daan C. Swarts@DCSwarts·
Are you a bioinformatician and want to use your skills to support diverse research lines? Biochemistry @WUR is hiring a staff scientist in bioinformatics! Come join us :D
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Max Fürst (find me as @maxfus in BS)
Max Fürst (find me as @maxfus in BS)@MaxFus·
We also highlight a selection of great papers describing successful engineering campaigns of such enzymes, thus showcasing both the curse as well as the blessing of computationally engineering enzymes with non-prot parts (which make up more than 2/3rds of all enzymes 😳)
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Max Fürst (find me as @maxfus in BS)
Max Fürst (find me as @maxfus in BS)@MaxFus·
Luckily, in most cases, dedicated settings, manual adjustments, or crude hacks are described. We summarize common and exciting novel protein engineering workflows and outline what is known about how these tools can be used with enzymes featuring non-proteinogenic parts.
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Keşfet

@MartinPacesa @khRRustamov @tugraz @kclchemistry @PhilHolliger @UCLChemistry @WUR @elonmusk