TheYunLab

🌟 WE ARE HIRING! 🌟 Principles of Regeneration and Ageing in a cutting edge science-driven environment & core funding Outstanding POSTDOCS; BIOINFORMATICIANS & RAs: join us at CIMR-Chinese Institutes for Medical Research, Beijing. APPLY here: theyunlab.com Please RT

@GuonHuang @XiaoxinChen2024 @PNASNews Impressive, many congrats Guo and team!

Our new paper led by @XiaoxinChen2024 is out @PNASNews! bit.ly/4785aCD We built a tissue atlas of ~2K transcription regulators ➔ identified Tox3 as a long-sought Atoh1 amplifer in cerebellar development, tumorigenesis & evolution. 1/10 📢 We're recruiting postdocs!

The Chinese government is ramping up its support for science go.nature.com/4lsG479

@MaxUnfried Check out our latest paper in press: pubmed.ncbi.nlm.nih.gov/41689039/ 💪🏻

@MaxYunLab Excited to see what you’re finding next in Axolotl land :)

Can we use natures adaptations from other animals to extend healthy lifespan in humans? I believe so! But the missing ingredient is infrastructure at scale: a shared, standardized comparative biology dataset that de-risks discovery for everyone. And this is exactly the kind of “public good” philanthropy can catalyze, and we are building at @TTIScience. More in my article for @CFObyPostmedia in the comment.

This study provides new insights into axolotl age resilience and offers a model for understanding how long-lived vertebrates maintain reproductive capacity through 🕰️

Remarkably, they preserve early stage oocytes until advance ages, with old females spawning large numbers of viable larvae within the average lifespan. Interestingly they show follicular atresia concomitant with enlargement of egg size in late ages, likely a resilience strategy

New Year, New Paper for the Yun Lab! 🌟We find that Axolotls exhibit limited reproductive senescence and retain fertility throughout lifespan (pubmed.ncbi.nlm.nih.gov/41689039/). Kudos to Yuliia Haluza, in this great collab with @Tanaxolotl

@MaxUnfried Couldn’t agree more - and kudos for the pic ;)

@NornGroup Many thanks for sharing our work!

Research we covered in our #ARDD2025 field notes (linked below) is now published. @MaxYunLab showed axolotls can regenerate their thymus de novo after complete removal. Not partial regrowth from remnants like mammals can often manage, but full reconstruction. FOXN1, the transcription factor mammals need for thymus development, turns out to be dispensable for axolotl thymus regeneration. Midkine signaling appears to drive it instead. This is relevant for longevity because in mammals, the thymus shrinks with age, taking T cell production and immune function with it. Axolotls skip this process entirely, maintaining their thymus throughout life with roughly flat mortality risk. Understanding how they pull that off could eventually point toward ways to restore thymic function in aging humans.

@DanielMuozEspn1 @MunozEspin_Lab Congrats Dani, Masashi and all!

We are very excited to share our new article at @MunozEspin_Lab published in Nature Aging! nature.com/articles/s4358…

#CMMDR2026 was lovely & fun: great science, inspiring discussions, and grateful for the invitation to give a talk & chair a session. Huge congrats to the organisers!

First time in India, great science, food and friends.

The growth factor #midkine, but not the transcription factor Foxn1, may drive #thymus regeneration following complete removal of the organ in juvenile axolotls. Learn more in Science #Immunology: scim.ag/4pih6Zw

Very proud of organizing the EMBO Regeneration Workshop 2026 in Krems, in the heart of Austria, together with @simoesfili, Anna Jazwinska, @solana_jordi, Mansi Srivastava, @MaxYunLab and Juanma González-Rosa! #EMBORegeneration Registration is now open! meetings.embo.org/event/26-tissu…

Thanks to @ScienceMagazine for featuring our work: science.org/topic/article-… kudos to Christie Wilcox. @MaehrLab

Instead, #Midkine (MDK) and BMP signaling is required. MDK is a critical early trigger without which there is no regrowth

Alert: Our finding that axolotls regenerate their thymus de novo is out! science.org/doi/10.1126/sc…. A fantastic collab with @MaehrLab kudos to @aniaczark @MacrinaLobo Liz Bolaños Castro @fabianrost84 @DcGenomeCenter CIMR Beijing @PoLDresden @mpicbg , & @ClaireOlingy for editing

Thanks to @MicheleMarass for excellent comments and suggestions!