Lindsay McAlpine MD

Pleased to share our latest COVID Mind Study @ Yale publication: "Vascular inflammation in neuropsychiatric long COVID" Elevated markers of endothelial adhesion in LC correlates with lower verbal fluency and learning. doi.org/10.1016/j.bbih…

🫀🧠 My new paper in a cardiology journal: appreciate that my cardiology colleagues like my ideas and don't reject my papers because my ideas are "too new" - a comment I got from an editor of another journal on a different paper that was rejected. 🤪 heartrhythmopen.com/article/S2666-…

@bakermind Absolutely!

@McAlpineLabYale A few of us are trying to put together an R01 on cerebrovascular markers and stress in LC. We should chat sometime

🧠🔬 Clinical Trial in Focus The phase 2 ADDRESS-LC study (NCT06847191) is evaluating @BioVie_Pharma's bezisterim for neurological symptoms linked to Long COVID. Includes expert insight from @McAlpineLabYale, of @YaleMed. 🔗 Read more: hubs.li/Q04f27wF0

@TeamPostX @atranscendedman Agreed! There is going to be condition related overlap. These are the most widely validated and standardized tools to measure anxiety and depression. It'll be key to include this context in the interpretation of the results and to understand the overlap.

@atranscendedman Great study @McAlpineLabYale May I ask why you chose PHQ-9 & GAD-7, given several items overlap with long COVID symptoms? This raises a risk of measuring condition-related effects rather than depression or anxiety specifically, which could affect the validity of the results.

Yale and Johns Hopkins studied 252 people and found neuropsychiatric Long COVID linked to blood vessel inflammation, with some markers tied to poorer memory, fluency, anxiety, and depression. sciencedirect.com/science/articl…

@cstroeckw We are very busy with several studies! Participant recruitment is not a bottleneck. We need more stable funding to hire more staff. The clinic is also very busy and currently training an APRN. People keep asking me if the need is going away and it is definitely not, unfortunately

@McAlpineLabYale Hi Dr. McAlpine! What does your current clinical and patient base look like these days? Are biological samples and study participants still a major bottleneck for your research? TY.

HIRING! We are hiring postgraduate research associates starting June 2026. Please send talented folks interested in neuropsych Long COVID & PAIS our way! postdocs.yale.edu/posts/2026-01-…

Join our study site for the ADDRESS-LC Clinical Trial investigating Bezisterim in Long COVID! Email: LongCOVIDStudies@yale.edu addresslongcovid.com

Long COVID & Bezisterim Clinical Trial is now open at Yale! Email: longcovidstudies@yale.edu Website: addresslongcovid.com

Excited to share my friend and fellow Brown alum’s Neuro + Vertigo Physical Therapy account! Education | Support | Treatment instagram.com/balancingactre…

Indeed, a subset of people with post-acute infectious syndromes, including #MECFS and #LongCovid, do recover, but others don't. The heterogeneity of these complex syndromes is not rooted in one's thoughts, but in one's pathophysiology. A number of #MS patients lead a fully functional, minimally symptomatic life while many others with MS are very disabled and symptomatic. Here is the info from the Center for Disease Control and Prevention - no ME activists there. What is needed for people to get better is not psychotherapy; what is needed are effective therapies like we have for MS. cdc.gov/long-covid/liv…

Hot off the press! "CSF immune cell alterations in women with neuropsychiatric Long COVID" academic.oup.com/jid/article/do…

It's not too late to register and join the likes of Danny Altmann and other global experts from various fields to explore critical dimensions and pathophysiology of these debilitating conditions. #kslongcovid26 #longcovid #coronavirus #keystonesymposia kunm.org/local-news/202…

Heading to Santa Fe to attend the @KeystoneSymp #kslongcovid26 with amazing lab members and collaborators from @YaleCII. Looking forward to seeing everyone there! Safe travels to those who are coming. Will be thinking of you - who couldn’t be there 💙

@AbigailJane1246 Highly recommend Dr Alba Azola. She is highly familiar with your symptoms and everything on your list. profiles.hopkinsmedicine.org/provider/alba-…

@McAlpineLabYale I maybe in the wrong place but at this point I have nothing to lose. After years of documented health issues by numerous doctors & hospitals due to autonomic dysfunction I waited almost two years to get into the Hopkins POTS clinic. I went to the doctor 3 times. 1- She blew me off though she may have ordered blood work. 2- I begged for tests (she ordered 5). 3-without benefit of all test results she said "I have never seen this happen before" & "I don't know what else to do". After numerous other ridiculous events I called patient relations. Yesterday I received a letter that basically said they have done all they can do (5 tests that's it?) and offered to help me get an appointment with psych. Any shot you feel like helping me get a little bit of my life back?

This is new — @RobertKennedyJr states he “is 100% committed to finding treatments for #LongCovid.. I have a son who is really dramatically affected by LC.”

@brailemom ?

@McAlpineLabYale I hope that your previous approach that seemed to support the "preferential energy expenditure" idea has changed, Dr. McAlpine.

Join us at Yale School of Medicine for a public forum on Long COVID next week! Thursday, May 15th at 10:30am