Michael K Gilson

We are pleased to announce our third BindingDB free webinar! Building Machine Learning Models Using Data from BindingDB -- Dr. Pat Walters, Chief Scientist OpenADMET 8:00 am California time, February 24, 2026. Register here: uchealth.zoom.us/webinar/regist…

@GadSaad @Grokipedia @Wikipedia The grokipedia on "entropy" at least starts off as a verbatim copy of the Wikipedia entry.

I just checked my bio on @Grokipedia. The platform has incorporated several edits albeit there remains some repetition. That said, it is 100 times more complete than my corresponding bio on @Wikipedia. It's not even close. Here is my bio on Grokipedia: grokipedia.com/page/Gad_Saad

They’re literally shouting it out loud! Their plan to overturn the constitution and democracy. They’re not hiding it. They’re bragging about it. And the media are just ignoring it, or worse normalizing it; the biggest story perhaps in modern American history. Kill. Me. Now.

We are thrilled that ChEMBL 36 includes a LOT more of our open-access US Patent data! It's all about data-sharing :-) ebi.ac.uk/chembl/

A recording of the latest BindingDB webinar, Synergies between BindingDB and PubChem, Dr. Christopher Southan, is now available here: bindingdb.org

@LindseyGrahamSC @LindseyGrahamSC I thought you were an American. How sad that you embrace government control of the entertainment industry.

Political activism under the guise of comedy is not very effective nor is it funny. The desire to destroy Trump took over the desire to entertain. Hopefully the next person will be tough on everyone — and actually funny.

@joevaron @brownstoneinst I'm not at all convinced of the Brownstone Institute's commitment to truth, from what I'm seeing on their web page and from their apparent alliance with what is arguably a religious cult.

I'm truly enjoying the @BrownstoneInst retreat — the ideas are stimulating, the conversations are challenging, and the commitment to truth and humanity is inspiring. I am grateful to be among those working hard to build a better future for us all. #Brownstone #HopeInAction #MedicalFreedom @Honest_Medicine

#GenAI for drug discovery often use docking which is inaccurate. Molecular dynamics are more accurate but too expensive. Our #ICML2025 paper explores ``Multi-Fidelity Latent Space Active Learning''. Paper: arxiv.org/pdf/2410.11226 Code: github.com/Rose-STL-Lab/M… (1/3)

Thanks, David! That means a lot to us, and I hope others also find it interesting.

The Need for Continuing Blinded Pose- and Activity Prediction Benchmarks pubs.acs.org/doi/10.1021/ac… @jchodera @MichaelKGilson @davidlmobley @NittingerEva @madAniceP @mattschap @wpwalters #JCIM Vol65 Issue5 #Perspective

Time to switch :-)

You're invited! 😀

@dank_herbert @mbeisen @NIH Private companies typically have higher indirect cost rates than universities.

The indiscriminate and ill-conceived slashing of indirects by the @NIH yesterday must be amended if want to restore America’s leadership role biomedical research. 15% simply isn’t enough for institutions to provide the basic infrastructure needed to run a successful lab. I say this as someone who has been and remains deeply critical of the NIH, its funding system and of the ways universities are structured and spend money. We would all benefit from a genuine reexamination of how and to what @NIH funds are allocated, and I remain optimistic that once the dust settles and new NIH leadership is in place that this is what will happen and this hack job by people who don’t understand or care about research will be forgotten. And I’m sorry but I can’t help but laugh at the people who are demanding a full-throated defense of the current indirect levels. Nearly every PI I’ve known for my entire career has complained about excessive indirect rates. This is mostly because, despite their importance, even most PIs haven’t bothered to actually understand them, and because they don’t FEEL that universities are actually spending the money to support their research. Whether they are or not nobody really knows because in the typically Byzantine maze of university budgets it’s often very hard to figure out. There are also lots of actual shenanigans that go on especially at places with the highest indirect rates to use funds to build out the institution and increase its power rather than to directly support funded research projects. And anyone who says administrative bloat at universities isn’t real and partially fueled by indirects is either blind or part of the bloat. So let’s get organized to have an actual constructive response to this firebomb. Scientists need to advocate for what is best for research - and we have to do it ourselves because the institutions that claim to represent us - universities and scientific societies in particular - have their own goals that often do not align with ours. We also have to remember that grants are not an entitlement. We are not owed anything. If we want to continue benefiting from the public support we have always enjoyed, we have to show the public and their representatives - even ones we might not always agree with - that we’re spending their money wisely.

We are excited to announce publication of our latest BindingDB update paper! academic.oup.com/nar/advance-ar…

@GadSaad Trump is profoundly —disqualifyingly — corrupt.

Trump has many qualities (honey badger mindset, grit, perseverance, entrepreneurial spirit) and numerous flaws. Harris is an empty human being whose rise has utilized knee-level talents. She is void of the capacity to formulate a single meaningful sentence on anything. To the extent that she does formulate a thought, it is incongruent with ANY of the foundational values on which the United States was built.

Academic research about Section 174 is beginning to be published and it confirms what everyone in industry already knows: 174 is destroying American research and innovation.

@ProjectLiberal @FukuyamaFrancis Is Fukuyama credible, given that history has resumed with a vengeance?

Francis Fukuyama (@FukuyamaFrancis) explains how distributing leadership across multiple individuals can prevent governments from making drastic mistakes, and how failing to do so can lead nations to ruin.

Time to let the Ukrainians hit what they need to hit, wherever it is located. Yet another massive attack on civilian infrastructure is further proof that Russia has no interest in ending this war or negotiating peace

Do you know Python and have experience with RDKit? Do you want to work in an exciting and multidisciplinary environment?The AutoDock project is hiring a programmer, apply here! recruiting2.ultipro.com/SCR1003TSRI/Jo…

“‘I think we are going to see mass refusals to certify the election’ in November, Democratic lawyer Marc Elias told Rolling Stone. ‘Everything we are seeing about this election is that the other side is more organized, more ruthless, and more prepared.’” thebulwark.com/p/republicans-…