Michael Kugler

Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and @KatjaLammens in @hopfnerlab at @GeneCenter_LMU. Now online at @NatureComms.

@JeongmingyuG Awesome, Mingyu!

Thrilled to share my first first-author pre-print! I hope our work adds value to the cryo-ET community. Huge thanks to everyone who supported this journey!

Join us in our next #MunichRNA19F! 📍 @MPI_Biochem 📅 19/02/2025 We will hear amazing talks from Shuyao Sha (@kusterlab ), @lauradmartens (@gagneurlab), @Michael_Kug (@hopfnerlab), Marc Schmitt-Supprian. Don't miss it! 🧬😀

@JeongmingyuG @KatjaLammens @hopfnerlab @GeneCenter_LMU @NatureComms Thank you, Mingyu! :)

@Michael_Kug @KatjaLammens @hopfnerlab @GeneCenter_LMU @NatureComms Congrats Michael!

Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and @KatjaLammens in @hopfnerlab at @GeneCenter_LMU. Now online at @NatureComms.

Thanks to all the attendees, speakers and discussion leaders that made the 2024 3DEM GRC grc.org/three-dimensio… an exciting and memorable event! #3dem

The #Schlafen11 protein, identified as sensor for single stranded DNA #ssDNA, may be part of new class of pattern recognition receptors. Read more: scim.ag/7kA

An inspiring example! Petr Těšina moved back to Czechia from Germany (LMU) when he won an ERC Starting Grant. It allows him to set up a research team at @CEITEC_Brno and take his cutting-edge to new levels. @petesoi1

In our next meeting #MunichRNA20M, we will hear the amazing RNA science of Yung-Li Chen from @METorresPadilla lab (@Helmholtz_MUC) and @Michael_Kug from @hopfnerlab (@LMU_Muenchen). Hope to see you there! 📅20/03/24 3pm 📍@MPI_Biochem

@FASEB #HNASRC #Helicase23 is a wrap. Had a great time connecting with old friends, meeting some great new folks, and learning loads about RNA and DNA helicases. What a great turnout and lineup! Looking forward to #Helicase25!

Our study on the "structural conservation of antibiotic interaction with ribosomes" is out in @nsmb. Mammoth effort led by Helge Paternoga and @caillancm reporting structures of 17 antibiotics in complex with the ribosome at 1.6-2.2Å resolution...PDF at... nature.com/articles/s4159…

Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the @EustermannLab @embl and all authors!!! science.org/doi/10.1126/sc…

The 1st international Schlafen (SLFN) meeting was held @broadinstitute this week. Amazing to meet colleagues all working in an under-researched group of genes/proteins. Can’t wait for the next…..#slfn #genetics #schlafen #sleep

Here's a thread about our recent eukaryotic RQC publication in @MolecularCell, which was my last project in the @BeckmannLab. Thanks to @inada_lab and all co-authors!

Glad to help regarding better understading of B–H⋯π and C–H⋯π hydrogen interactions on carbonic anhydrase II/carborane-based inhibitors - combination of X-ray crystallography and quantum-chemical calculations. @IOCBPrague @iic_rez @nekwajz

Check out our newest publication. Great work by Franziska Kunert and Felix Metzner! Thanks to all authors for the team effort. @MarkusHopfler @PfanderLab S.Eustermann et al. Structural mechanism of extranucleosomal DNA readout by the INO80 complex science.org/doi/10.1126/sc…

The saga of carbonic anhydrase inhibitors continues - by using three different approaches we were exploring the potential exosite of carbonic anhydrases. Fruitful collaboration at @IOCBPrague. Out now at @rsc_medchem. pubs.rsc.org/en/content/art…

Fast cryo-electron tomography data acquisition to determine molecular structures in situ nature.com/articles/s4159…

Today we introduced Chroma, a generative model that creates new proteins & protein complexes given geometric & functional constraints. It learns to transform unstructured, random 3D shapes into #protein molecules, which can have tens of thousands of atoms. ow.ly/Txn750LShFp

@EMDB_EMPIAR @PDBeurope @natcomms @GeneCenter_LMU Thank you for the spotlight. I will just add the right handle for @NatureComms.

Released today @EMDB_EMPIAR & @PDBeurope, & published @natcomms, #CryoEM structures of the Human Schlafen-11 dimer apoenzyme. Study by F. J. Metzner et al., from @GeneCenter_LMU @ 2.8 Å resolution.