Michela (Micky) Marinelli

A super short talk about a course I teach and a topic I am so passionate about 2022 CSICon Sunday Morning Papers session - Talk 3 youtu.be/xGa66W3QKao

Maternal cannabis use disorder is associated with a 3x risk of autism.

2 weeks without smartphone internet significantly improved mental health. The effects were similar to an antidepressant medication.

Numerous studies show that people who take acetaminophen have fever more often that people who don’t. So acetaminophen causes fever — not (to be read à la Borat). Seriously though… acetaminophen is the most prescribed antipyretic during pregnancy- how about looking at the reason they take acetaminophen as a possible cause?

The original article: "Numerous well-designed studies have indicated that pregnant mothers exposed to acetaminophen have children diagnosed with neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), at higher rates than children of pregnant mothers who were not exposed to acetaminophen." ehjournal.biomedcentral.com/articles/10.11…

Postdoctoral Training Fellowship Opportunity at The University of Texas at Austin! The University of Texas at Austin’s “Alcohol Training Grant,” an NIAAA-supported T32 Training Program has TWO immediate openings for a postdoctoral fellow. Applications are invited for this 2+ year postdoctoral training fellowship in the neurobiological and behavioral effects of alcohol. Year 3 depends on a successful competing renewal. Training opportunities span state-of-the-art translational, psychosocial, and preclinical approaches in animal models and human subjects research including behavior, bioinformatics, genetics, electrophysiology, imaging, molecular biology, neurochemistry, and neuropharmacology. Integrated with the Waggoner Center for Alcohol and Addiction Research, this opportunity is available for any one of our training faculty’s laboratories. ELIGIBILITY: Applicants must have completed their doctoral training in neuroscience, psychology, or a related field and be U.S. citizens or permanent residents. Competitive applicants will have a strong track record of scholarly productivity and commitment to a career in alcohol research. UT is an equal-opportunity employer. Position is open immediately. Stipend, medical insurance coverage, and travel funds are supported by this T32 Training Award. APPLICATION PROCEDURE: Initiate the application by emailing the director, Dr. Kim Nixon, at kim.nixon@austin.utexas.edu or the training faculty of interest with a letter of interest and CV. Review of applications begins immediately until the position is filled.

Really interesting papers, confirming and extending what many believed true for a while. The last 20 years gave us the illusion of super hyper specialization of brain regions thanks to opto/chemogenetics. Turns out we were just under a lamppost. We're in a "neo-Lashley" era. Brain functions are mostly spread out throughout the brain, not in one spot. If you’re not already looking elsewhere than under the lamppost, you should.

Being kind boosts mental health more than seeking joy. Evidence: Doing 3 random acts of kindness a week is enough to reduce depression, anxiety & loneliness. It's more beneficial than doing nice things for yourself. Self-care feels good, but generosity builds lasting bonds.

@mantschjr @brainaddiction @LowethJessica @yavinshaham @FerrarioLab Thanks! Would love details! Micky.marinelli@austin.Texas.edu

@MickyMarinelli @brainaddiction @LowethJessica @yavinshaham @FerrarioLab Hi Micky - sorry for not seeing this earlier (I stay off X these days). We are now using custom made polyurethane catheters from Access Technologies / Norfolk Medical; we provide them with the pedestal (Protech). Can send you details if you want them.

DuPont-Dow Corning no longer makes the silastic catheters we were using for jugular catheters. What do you all use? @brainaddiction @LowethJessica @yavinshaham @FerrarioLab @mantschjr

@brainaddiction @LowethJessica @yavinshaham @FerrarioLab @mantschjr Thanks!

@MickyMarinelli @LowethJessica @yavinshaham @FerrarioLab @mantschjr We use micro-Renathane tubing from Braintree

ID 0.012"; OD 0.025"

How Does Alcohol Affect the Gut Microbiome? nytimes.com/2024/01/30/wel… via @NYTimes @Lorenzo__Leggio @jfcryan

Curious about science, health, or the brain? Attend free seminars—live in Austin or online from anywhere. Engaging topics. 📅 Weekly sessions | 🎓 Open to all

Free seminars at UT this summer! Seminars are hybrid (both in-person and on zoom)- see QR codes at the end of this message. 10 June Dr. Margaret Keane Title: Understanding human memory through the study of amnesia Goal: Learn about the life of the famous amnesic patient H.M, and gain an appreciation of his contributions to our understanding of how memory is organized in the brain. 17 June Dr. Linda Noble Title: The brain-injured child- where “lived experience” intersects with lab-based research Goal: Understand age at time of injury as a modifier of recovery, the concept that “time is brain” and the evolving expectations of family. 24 June Dr. Tori Williams Title: The neuropsychology of dementia Goals: Describe the field of clinical neuropsychology, the role of a neuropsychologist in clinical and research settings, and the training requirements to becoming a neuropsychologist. Discuss the clinical dementia syndrome, how various dementia pathologies uniquely impact cognitive functioning, and how neuropsychological assessment is used to diagnose dementia 01 July Dr. Josh Cisler Title: TBD, topic: PTSD 08 July Dr. Micky Marinelli Title: The illusion of objectivity in scientific research Goal: Explain how cognitive and scientific biases can impact our ability to perform, interpret, and consume "good science" 15 July Dr. Steve Warach Title: Acute stroke and the challenges of clinical research Goals: Understand basic concepts of acute stroke Become familiar with successful approaches to developing stroke therapies 22 July Dr. Charles Nemeroff Title: The management of treatment resistant depression: the art and the science Goals: Explain the latest treatment advances and research findings for treatment-resistant depression (TRD). Describe emerging strategies in the use of atypical antipsychotics and new agents in the treatment of TRD.

I am glad you questioned it Good for you A similar thing happened to me but on a very mild thing: sleep apnea. The report said my oxygen dropped to 82 and I had I don’t remember how many incidents of apnea I had the recording and saw that my 82% was before I went to sleep (when I had turned on the machine but was still installing the sensor. And the episodes were while I was walking around in the house so not asleep.

My oncologist tried to stop my chemotherapy* treatment last week because of a one-page synopsis he had read regarding my recent MRI, which mentioned that one of my brain tumors had progressed. It turns out he had never actually looked at the MRI itself; and the specialist who wrote the synopsis had not actually compared the new images to my previous MRI from 2024. I was skeptical, as my symptoms had not progressed; so I asked my oncologist to show me a comparison of the two most recent MRIs, to demonstrate the growth. So, he brought them up on his screen and showed me a clear difference between image on the left and one on the right. "But the one on the left is the 2017 MRI," I said. "We both know the tumor has grown since then." The doctor was surprised, and said, "You're right. I'm not sure why the 2024 MRI isn't showing up." Anyway, we had to go to a different room and use a different computer to find last year's images. When my oncologist finally brought them up, he realized there was a clear REDUCTION in the size of my tumor, as well as a loss of contrast, indicating that the tumor was dying. So, the chemotherapy was working after all! Had I taken my doctor at his word, and stopped my chemotherapy, I would have soon needed an extremely risky brain surgery that would have changed my life forever. We are living through a crisis of competence in America — or is it in the world as a whole? It is absolutely essential that we remain vigilant and look out for our own health, because we apparently can no longer trust our doctors to do it for us. Remember to ask questions, get second opinions and, above all, don't just assume that your doctor is infallible. Now more than ever, your life is in your own hands.

.@mickymarinelli and team @UTAustin designed and developed a PKCε small molecule inhibitor that reduces cancer chemotherapy-induced pain and prevents & reverses opioid withdrawal pain: insight.jci.org/articles/view/…

Webinar coming up! linkedin.com/posts/national… @NINDS4Rigor

@KateHydeNY She was 16 years old then….

BREAKING: First documents from the JFK Files have been released. All I have to say is… WOW.

@brainaddiction Oh my goodness…. I wish you the very best! I know you can do this! Be strong. Go in there feeling all of the love and encouragement from all of us :-)

Two weeks ago, they found a tumor in my abdomen. imagine a big, juicy orange just sitting there. Routine exam, totally unexpected, and yeah, it’s scary as hell. I’d be lying if I said otherwise. Tomorrow’s the big day: a long surgery to cut this thing out, along with part of my small intestine. I don’t know if it’s malignant yet, I’m very nervous, but I’ve got confidence it’s going to go well. I’m in the hands of one of the best surgical oncologists @UCSDHealth seriously, I lucked out. I’ been thinking a lot lately obviously and I can’t say enough about my brilliant colleagues @UCSD and @NIH researchers and clinicians who pour their hearts into advancing science and fighting diseases. I’ve gone from being an NIH-funded researcher to a patient trusting my life to an NIH-funded surgeon. It’s a full-circle moment that hits hard. None of this—none of the research, the treatments, the hope—would exist without a robust healthcare infrastructure and the significant indirect costs from NIH that make it all possible. Slashing those funds to 15% IDC, doesn’t just threaten my lab and my research to find a cure for addiction, it threatens my life right now, and the lives of so many others counting on this system to survive. This is one of the toughest challenge I have ever faced. But I’m ready. Let’s kick this tumor’s ass!