Molecular Neurodegeneration Advances

#Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and #mitochondria in excitatory neurons Claudia Espinosa-Garcia @ClauEspinosa82 Upasna Srivastava, Prateek Kumar...Srikant Rangaraju @rangarajulab @YaleMed link.springer.com/article/10.118…

🚨 Registration is NOW OPEN for ISMND 2026! Join us in Hong Kong (or virtually) from October 20-23, 2026 for invited talks from leading experts, selected short talks & posters, and plenty of networking! 🔗 Register now: ismnd2026.org/how-register

Female-specific Cx3cr1-driven regulation of #ALS and #Alzheimer’s risk genes in #tauopathy Ari Sudwarts & Gopal Thinakaran @ThinakaranLab @USFHealthByrd #microglia #transcriptome link.springer.com/article/10.118…

Pyk2 plays a critical role in #synaptic dysfunction during the early stages of #AlzheimersDisease Quentin Rodriguez, Floriane Payet, Karina Vargas-Baron...Alain Buisson @GINeuroGrenoble #hippocampus #amyloid link.springer.com/article/10.118…

We are excited to announce Dr. Lance Johnson @universityofky as our next ISMND webinar speaker! Title: From Risk to Resilience: Cell-Specific #APOE4→APOE2 Switching in #AlzheimersDisease Feb 20, 2026 10AM - 11AM (ET) Host: Julia TWC, Ph.D. Register: bit.ly/4kS80kV

Spilling the T: #Tcells in #tauopathy mechanisms, disease progression, and therapeutic horizons Megan E. Bosch & Jason D. Ulrich @WashU link.springer.com/article/10.118…

Distinct CSF #lipidomic profiles are associated with five #proteomic subtypes in patients with #AlzheimersDisease Georgia Malliou, Lianne M. Reus, Yolande. A. L. Pijnenburg...Betty M. Tijms @bettytijms link.springer.com/article/10.118…

🚨 HAPPENING NOW!

#Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau #proteolysis Caroline Ackley...Paul J. Sampognaro, Aimee W. Kao @AimeeKaoLab @UCSFmac @UCSF #amyloid #AlzheimersDisease #autophagy link.springer.com/article/10.118…

#Genetic evidence supports therapeutic modulation of #progranulin levels in #AlzheimersDisease Chloe Robins, John D. Eicher, Jimmy Liu...Chun-Fang Xu @GSK link.springer.com/article/10.118…

Differential downstream signaling in #microglia lacking #Alzheimers-related #TREM2 or its adaptor TYROBP/DAP12 Gabriela E. Farias Quipildor...Stephen R. J. Salton, Michelle E. Ehrlich @IcahnMountSinai link.springer.com/article/10.118…

Correction: Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleinopathy link.springer.com/article/10.118…

GPCRs with #genetic associations to #AlzheimersDisease traits: an underdeveloped target class for disease progression Jessica Karson, Laurent Chesnel, Susan Acton @AdisoTx link.springer.com/article/10.118…

Development of #cannabinoid-based therapies for #Parkinsons disease: emphasis on targeting cannabinoid receptors as CB2, PPAR-γ and GPR55 receptors Sonia Burgaz, Santiago Rodríguez-Carreiro...Javier Fernández-Ruiz @CIBER_ISCIII #endocannabinoids link.springer.com/article/10.118…

Divergent #TDP43-regulated and TDP43-independent cryptic splicing in the cortex and #spinalcord Dwight F. Newton, Rena Yang, Johnny Gutierrez...Brad A. Friedman @RocheCanada @genentech #ALS #AmyotrophicLateralSclerosis #FrontotemporalDementia link.springer.com/article/10.118…

Happy New Year! Starting our 2026 webinar series, we are delighted to announce Dr. Tony Wyss-Coray @wysscoray @Stanford as our January speaker! Title: Aging through the lens of outliers Jan 22, 2026 8am PT/11am ET Host: Dr. Hui (Iris) Zhang Register: bit.ly/3NgMgSN

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @BrighamWomens @harvardmed #AlzheimersDisease #complement #amyloid #neuroinflammation link.springer.com/article/10.118…

Global C3 lowering in adulthood protects against hippocampal dysfunction and #cognitiveimpairment in aged mice Andre F. Batista, Jessey Presumey, Brijendra Singh...Cynthia A. Lemere @BrighamWomens @harvardmed #complement #neurodegeneration link.springer.com/article/10.118…

Genetics of #PLCG2 expression and splicing relative to #AlzheimersDisease risk Andrew K. Turner, Kennedy Dotson, Qi Qiao...Steven Estus @UKSBCoA @universityofky #genetics link.springer.com/article/10.118…