The Muir Lab

What if protein function could be triggered only when the right cell cues are present? With SMART, we combine split inteins and logic gating to create a programmable system for cell-specific protein ligation, thus opening new doors for synthetic biology and cell targeting.

Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele

With a background in math and physics, Postdoc Jeremy Owen's the first-ever computational theorist hired into the @MuirLab. He investigates the “dizzying complexity” of chromatin. Enjoy the first of our stories celebrating the postdocs of @PrincetonChem: bit.ly/4lgOmiy

2/9. This work was a true teamwork. Huge congratulations to our collaborators at @kadochlab , @MuirLab , @GygiLab , Michael Gross (WashU). Special thanks to Kadoch lab members - @CKadoch, Dr. Kaylyn Williamson, @alex2110x, Aasha Turner, Maxwell Allison, Kevin So!

1/9. Happy 2026, everyone! We are excited to share our new study on how mSWI/SNF chromatin remodeling complexes interact with DNA sequence-specific Transcription Factors (TFs), out this week in Science! @ScienceMagazine Doi: doi.org/10.1126/scienc…

Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I3vVUPVb…

Congratulations to our Tom Muir @MuirLab on being awarded the @AmerChemSociety's Ralph F. Hirschmann Award in Peptide Chemistry for exceptional achievement in the field. Well done, Tom! Enjoy our story here: bit.ly/3KhNITt

Congrats again to all our graduates!

And last but not least, we have Dr Yingzi Huang, who presented a wonderful seminar on her chromatin within the context of DNA damage. Stay tuned for this story…

With the start of the new academic year comes several farewells from our lab, as senior members of the lab graduate. First off, congratulations to our “transposein” Dr Yi Hua, who is heading off to @Stanford for a postdoc with @aliceyting

Congratulations @MuirLab postdoc Jason Johansen-Leete on his Life Sciences Research Foundation Fellowship, sponsored by Amgen, for his project: “High-resolution mapping of the BAF interactome with novel chemoproteomic technologies.” Well done, Jason!

Congratulations to Tom for receiving the Ralph Hirschmann award in Peptide Chemistry! @PrincetonChem cen.acs.org/people/awards/…

Nature research paper: Programmable protein ligation on cell surfaces go.nature.com/40HmcEs

The @MuirLab introduces a groundbreaking protein activation platform that allows “exquisite precision,” in @Nature last week. Enjoy our story on this @NIH funded research by Christian, Girum, Nicholas, Xuanjia, Yutong and Tom: bit.ly/3IThY6F

Very happy to share this preview in @TrendsinBiotech two cool intein papers just out in @ScienceMagazine by @GMBurslem, @ophirshalem & @MuirLab. Beautifully written by my new postdoc, Kevin Schiefelbien🤩 @Penn @PrincetonChem authors.elsevier.com/a/1lXcKc9XEr8iU

Congratulations to Christian, Girum, Nick, Xuanjia, and Yutong! Link: nature.com/articles/s4158… @PrincetonChem @PrincetonInnov

We anticipate that this technology will enable targeted formation of biomolecules with reduced off-target toxicity. This paper is the start of many applications for SMART and stay tuned for more!

What if protein function could be triggered only when the right cell cues are present? With SMART, we combine split inteins and logic gating to create a programmable system for cell-specific protein ligation, thus opening new doors for synthetic biology and cell targeting.