The Maze Lab

I am absolutely humbled and honored to have been selected as a new HHMI Investigator. A huge shout-out to all of my brilliant lab members (past and present), outstanding collaborators and incredible mentors along the way who made this a possibility!!

an autonomous chromatin signaling axis whereby H3Q5ser is read by the Quinone reductase enzyme 2 (QR2) to support human neuronal gene expression and cellular maturation. Happy reading, everyone!

Marro, and many others! Since H3 serotonylation occurs at Gln5, we (and others) have previously focused much of our attention on the mark's interactions with adjacent H3K4me3 in guiding permissive gene expression in the brain and beyond. Here, however, we have identified

Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele

2nd- or 3rd-year PhD student? Applications for @hhmi_science's #GilliamFellows Program open 9/1! Robust dissertation support, an incredible community of scientists, tailored professional development (for you *and* your thesis advisor), & so much more. bit.ly/4qQArRh

Check out the January 2026 issue of Trends in Neurosciences: cell.com/issue/S0166-22… Free featured content & more: cell.com/trends/neurosc… Cover article: ‘Reimagining biogenic amine signaling in the brain and beyond’, David Vinson & Ian Maze @themazelab cell.com/trends/neurosc…

CONGRATULATIONS to @IcahnMountSinai's Dr. Ian Maze on being endowed as a Mount Sinai Professor. This well-deserved recognition is the highest academic distinction a university can bestow upon a faculty member. Incredibly proud to have Dr. Maze as a colleague & mentor!👏

Reimagining biogenic amine signaling in the brain and beyond: Trends in Neurosciences cell.com/trends/neurosc…

🎉CONGRATULATIONS to the #MazeLab's @BenjaminWeekley who has received an @NIH F32 this year from @NIMHgov to study "Mechanisms of Histone Serotonylation and MLL5 in Coordinating the #Epigenome during #Neurodevelopment". Learn More about Dr. Weekley's work👉reporter.nih.gov/search/IzFGOTR…

The One Mind Rising Star Awards were created to fuel bold ideas that improve lives, and 2017 Awardee Ian Maze, PhD, is a powerful example of that vision in action. Congratulations to Dr. @ian_maze2 on receiving the ACNP Daniel H. Efron Research Award for his groundbreaking work that's reshaping how we understand the brain & mental health. When Dr. Maze received his Rising Star Award, One Mind invested in his pioneering effort to develop a simple blood test that could identify who is most vulnerable to stress, who may develop major depression, & who is most likely to benefit from certain antidepressant medications. This kind of test could transform mental health care by helping people get the right support & the right treatments faster. That early support helped accelerate discoveries that have continued to push the field forward. Today, Dr. Maze is a Professor & Director of the Center for Neural Epigenome Engineering at @IcahnMountSinai & one of the youngest Howard Hughes Medical Institute Investigators. His career reflects exactly why the Rising Star Awards matter: identifying exceptional scientists early & giving them the platform to make breakthroughs that improve lives. Learn more about the Rising Star Awards: onemind.org/what-we-do/one… Read the ACNP's full press release: files.constantcontact.com/61d9ccf2601/92…

So incredibly honored to be one of this year’s recipients of the @ACNPorg Daniel H. Efron Research Award, along with my friend and colleague @TheErinCalipari . Shout out to all my amazing current and former lab members (and our outstanding collaborators) who made this a reality!

Calling all rising juniors & seniors: Interested in biological or biomedical research? Apply now for our ’26 Summer Undergraduate Research Experience Program! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows

New preprint alert!! In our last work we have found that Tissue stiffening primes migratory cell states by allowing histone serotonylation! #biomechanics #xenopus #chromatin #neuralcrest #devbio #cellmigration #frogpower biorxiv.org/content/10.110…

Thrilled to announce the upcoming Center for Epigenetic Research Symposium @MSKCancerCenter on Nov 17! 🎉 A full day of cutting-edge science featuring stellar external speakers & our outstanding trainees. Registration is now open! Join us in NYC or virtually from anywhere! link⬇️

So excited my doctorate work (and this excellent Preview by Yuhui Cui) is finally out @Neuron! We used human MDD profiling + mouse manipulation studies to identify an epigenetic regulator linking OFC astrocyte reactivity -> neuronal hyperexcitability -> stress susceptibility.

many amazing collaborators, without whom, none of this would have been possible. Hope you all enjoy!

But I couldn’t be more excited to finally have this work published. Also, a huge thanks to our incredibly helpful Editor, Dr. Ted Dobie, and our insightful Reviewers at Neuron, who truly demonstrated what scientific review should look like. Finally, a huge thanks to our

So incredibly excited to be able to officially highlight the outstanding work of @SashaLFulton, a previous superstar PhD student in my lab and now a superstar postdoc in the @IshmailSaboor lab at Columbia (also an @HHMINEWS Hanna H. Gray Fellow), now out at @NeuroCellPress !!

.@SinaiBrain & @IcahnMountSinai congratulate @EricJNestler for his election to @theNASciences of the USA. This great honor recognizes Dr Nestler’s cutting-edge work on the molecular basis of drug addiction & depression & on advancing the field of psychiatry into the molecular era

How do the brain & body communicate w/ each other? Our thoughts & emotions often feel in sync w/ physical sensations in our bodies. Why? Find out, CHECK OUT @RasikaIyer22's blog, dropped by MiNDS @SinaiNeuro this morning! #BrainAwarenessWeek #BrainWeek💓 mindatsinai.com/blog/hormones