Muzumdar Lab

555 posts

Muzumdar Lab

@MuzumdarLab

Studying genetic, environmental, and host factors in tumor progression of #PancreaticCancer and #LungCancer @YaleGenetics @YaleCancer @CancerYale @YaleMed

New Haven, CT Katılım Şubat 2018

417 Takip Edilen1.3K Takipçiler

Muzumdar Lab retweetledi

Yale Department of Genetics@YaleGenetics·18 May

It's not how much fat you eat, it's what kind 🥑 @YaleMed Prof. Mandar Muzumdar @MuzumdarLab shows how monounsaturated fats protect pancreatic cancer cells from ferroptosis, while polyunsaturated fats increase their vulnerability. See more here👇medicine.yale.edu/news-article/t…

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Yale Cancer Center@YaleCancer·15 May

Research from @Escobar_Lab + team identified a metabolic vulnerability in an aggressive subtype of #pancreaticcancer. Targeting the #K17-driven pathway improved chemotherapy response and doubled survival in preclinical models. aacrjournals.org/cancerres/arti… @SmilowCancer @CR_AACR

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Yale Cancer Biology Institute@CancerYale·14 May

Great job Gigi and all at the Muzumdar and Liu Labs! We love to see these collaborative papers among our amazing labs at #YCBI @Yanshen73854711 @MuzumdarLab @YaleWestCampus @YaleCancer @YaleMed

Muzumdar Lab@MuzumdarLab

🎉 Excited to share our new paper led by @Xiangyu_GigiG in @CR_AACR! 🧬 We flip the script on the RAS/PI3K relationship: PI3K is more than a RAS effector, it is also its regulator! @YaleCancer @CancerYale @YaleMedicine @YaleGenetics @yalepathology aacrjournals.org/cancerres/arti…

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Yale Cancer Biology Institute@CancerYale·12 May

Join us for a MORNING seminar: “From mouse to man: Genetically engineered mouse models reveal conserved mechanisms of metastasis in human cancer” with Cory Abate-Shen, Columbia University, Friday June 5 @ 9:00AM, at YCBI #YCBI @YaleCancer @YaleMed @YaleWestCampus

Yale Cancer Biology Institute tweet media

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Yale Cancer Center@YaleCancer·7 May

New research from @MuzumdarLab identifies PI3K-driven wild-type RAS activation as a key mechanism of resistance to KRAS inhibition in #pancreaticcancer. Combining PI3K and KRAS inhibition may help enhance therapeutic response in PDAC. aacrjournals.org/cancerres/arti… @SmilowCancer @CR_AACR

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Muzumdar Lab@MuzumdarLab·7 May

💡 This redefines the classic KRAS→PI3K hierarchy and reveals a bypass route that supports resistance to mutant KRAS–specific inhibitors. Special thanks to collaborators (@Yanshen73854711 @moitrayee_lab) and funders (@NIH @NSF @lustgartenfdn @AmericanCancer)!

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Muzumdar Lab@MuzumdarLab·7 May

🧩Mechanistically, PI3K activity promotes PIP3-dependent membrane recruitment of GAB1 to form an EGFR/SHP2/SOS1 signalosome, enabling wild-type RAS/MAPK signaling. What’s more? This leads to resistance to KRAS inhibition, providing a rationale for co-targeting PI3KI and KRAS. 🎯

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Muzumdar Lab@MuzumdarLab·7 May

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Yale Cancer Center@YaleCancer·7 May

.@YaleCancer #GrandRounds, Dr. Prasanna Ananth asks, “What defines high-quality end-of-life care for children with #cancer?” and provides insight into both what and how we measure what is most important to families with children facing #advancedcancer. #childhoodcancer. Watch her full talk youtube.com/watch?v=4zPhlg… @SmilowCancer @YalePediatrics

YouTube

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Yale School of Medicine@YaleMed·5 May

In a new study, @YaleGenetics researchers report that when it comes to your risk of pancreatic #cancer, the types of #fat in your #diet matter more than the amount of fat consumed: medicine.yale.edu/news-article/t…

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Yale West Campus@YaleWestCampus·4 May

New findings from @MuzumdarLab @CancerYale suggest that, for pancreatic cancer, the type of fat you consume matters more than the amount. bit.ly/islessmore @CD_AACR

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Muzumdar Lab retweetledi

Elizabeth McKenna@ElizSMcKenna·30 Nis

Now online in @CD_AACR: Diet-induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas - by @ChristianFRuiz @MuzumdarLab and colleagues @YaleGenetics @YaleCancer @CancerYale @YaleMed

Cancer Discovery@CD_AACR

Now online: Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas doi.org/10.1158/2159-8…

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Yale Cancer Center@YaleCancer·29 Nis

New research from @MuzumdarLab shows it’s not how much fat you eat, but the type that may drive risk of #pancreaticcancer. Some fats were found to even suppress tumors. medicine.yale.edu/news-article/t… @SmilowCancer @YaleGenetics @CD_AACR

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Christian F. Ruiz@ChristianFRuiz·29 Nis

How does diet causally influence tumor development? Fat composition—not amount—rewires the pancreatic lipidome to control ferroptosis sensitivity and tumorigenesis. Grateful to all collaborators and excited to build on this! 👇

Muzumdar Lab@MuzumdarLab

🔔New paper alert! Why does high-fat diet promote #PancreaticCancer? And does the type of fat matter? Epidemiologists have asked this for decades. Our new paper in @CD_AACR shows that fat composition — not just fat quantity — governs cancer development . aacrjournals.org/cancerdiscover…

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Muzumdar Lab@MuzumdarLab·29 Nis

2/🔬 Mechanism: Dietary fatty acids integrate into membrane phospholipids and serve as substrates for lipid peroxidation and ferroptosis. • 🫒MUFA-rich membranes → ⬇️ferroptosis sensitivity (more disease) • 🌻🐟 PUFA-rich membranes → ⬆️ferroptosis sensitivity (less disease)

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Muzumdar Lab@MuzumdarLab·29 Nis

1/ 🍽️ New insight: We fed 12 isocaloric high-fat diets — same calories, different fat sources — to a faithful #PancreaticCancer 🐭model and found: • 🫒MUFA-rich diets (oleic acid) promote tumor growth in mice. •🌻🐟 PUFA-rich diets (omega-3) supressedtumor progression.

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Muzumdar Lab@MuzumdarLab·29 Nis

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Muzumdar Lab@MuzumdarLab·29 Nis

6/ ✅ Check out @YaleMed news story on the study: medicine.yale.edu/news-article/t…

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Muzumdar Lab@MuzumdarLab·29 Nis

5/ 💵None of this would have been possible without pilot awards from @YaleCancer @lustgartenfdn and key funding from @NIH @DamonRunyon

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Keşfet

@YaleMed @Escobar_Lab @SmilowCancer @CR_AACR @Yanshen73854711 @YaleWestCampus @YaleCancer @moitrayee_lab