Yale Department of Genetics

A decade post-PhD and not sure where your research is headed? 🤔 🔬 A new Nature Careers piece offers practical advice on how to reset your research direction strategically and make the most of every opportunity. nature.com/articles/d4158…

'Zombie cells' are back! 🧟 Researchers have developed a technique that inserts the genome of one bacterial species into the emptied cells of another, potentially opening new doors in synthetic biology nature.com/articles/d4158…

Rare disease diagnoses can rely on exome sequencing, but answers may be hiding in noncoding regions. 🧬 PromoterAI is a new deep learning tool that identifies pathogenic promoter variants, which may account for up to 6% of rare disease genetic burden 🔍 science.org/doi/10.1126/sc…

CONGRATS🎉to Dr. Xiaona Lu on being honored with 2 prestigious awards 🏆 at the @ASGCTherapy annual meeting! Her innovative research @YaleMed is advancing gene therapy 🧬 for neurodevelopmental disorders🧠! More👇 medicine.yale.edu/genetics/news-…

A single base correction in the postnatal brain can restore protein function and reverse behavioral abnormalities. 🧬 In vivo base editing of a CHD3 variant ameliorated key features of Snijders Blok–Campeau syndrome in mice. Read more here 👇 nature.com/articles/s4158…

It's not how much fat you eat, it's what kind 🥑 @YaleMed Prof. Mandar Muzumdar @MuzumdarLab shows how monounsaturated fats protect pancreatic cancer cells from ferroptosis, while polyunsaturated fats increase their vulnerability. See more here👇medicine.yale.edu/news-article/t…

The key to understanding autism may not be the genes themselves, but how they disrupt the brain. 🧠 Research co-led by @YaleMed profs Kristen Brennand and Ellen Hoffman reveals autism genes converge on shared neural pathways. Find the full study here 👇 news.yale.edu/2026/05/01/man…

Today at the 2026 ASGCT @ASGCTherapy Annual Meeting, our very own Xiaona Lu is receiving an Excellence in Research Award! 🎉 Xiaona is being recognized on stage during the George Stamatoyannopoulos Memorial Lecture. Congratulations — so well deserved! 🌟

What drives cell fate decisions during human cortical neurogenesis? 🧠 A new single-cell CRISPRi screen of 44 transcription factors identifies novel regulators including ZNF219, NR2E1, and ARX, with convergent roles in neurodevelopmental disorders 👇 nature.com/articles/s4158…

Why do the same genetic variants have different effects in different people? A new atlas of gene-environment interactions across nearly 1 million individuals reveals how the environment shapes genetic associations and what that means for precision medicine nature.com/articles/s4158…

TODAY! 05/12/26 Genetics Seminar Series/Genetics Clinical Grand Rounds at 10:15am, Dr. Clair Francomano, MD, presents: " Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Connecting the Dots Disease." Link below medicine.yale.edu/event/gencgran…

SAVE THE DATE! 05/12/26 for our Genetics Seminar Series/Genetics Clinical Grand Rounds at 10:15am, Dr. Clair Francomano, MD, presenting: " Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Connecting the Dots Disease." Link below medicine.yale.edu/event/gencgran…

🎉 Excited to share our new paper led by @Xiangyu_GigiG in @CR_AACR! 🧬 We flip the script on the RAS/PI3K relationship: PI3K is more than a RAS effector, it is also its regulator! @YaleCancer @CancerYale @YaleMedicine @YaleGenetics @yalepathology aacrjournals.org/cancerres/arti…

SAVE THE DATE! 05/05/26 for our Genetics Clinical Grand Rounds at 10:15am, Dr. Vahid Bahrambeigi, PhD presenting: " An Overview of Pelizaeus-Merzbacher disease (PMD) and Associated Neurological Disorders." Link below... medicine.yale.edu/event/gencgran…

🔔New paper alert! Why does high-fat diet promote #PancreaticCancer? And does the type of fat matter? Epidemiologists have asked this for decades. Our new paper in @CD_AACR shows that fat composition — not just fat quantity — governs cancer development . aacrjournals.org/cancerdiscover…

Researchers have characterized SNIPE, a novel anti-phage defence system in E. coli. 🦠 Localizing to the cell membrane, SNIPE cleaves incoming phage DNA during injection, revealing a mechanism of self vs. non-self discrimination. nature.com/articles/s4158…

TODAY! 04/28/26 Genetics Clinical Grand Rounds at 10:15am, Dr. Chen Zhao, PhD presents: "Molecular Diagnosis of Fetal Anomalies." Link below... medicine.yale.edu/event/gencgran…

TODAY! 04/28/26 Genetics Seminar Speaker Dr. Maude Baldwin, PhD, Max Planck Institute for Biological Intelligence, presents: "Functional evolution of the taste and digestive system in vertebrates." Link below... medicine.yale.edu/event/gensem04…

Researchers have identified CFAP20 as part of a pathway that salvages stalled RNA polymerase II near gene promoters. 🧬 Their findings reveal how cells prevent collisions between transcription and replication machinery. Check it out here 🔗 nature.com/articles/s4158…

Finally @iclr_conf after a day of flight debacles!