Neurogastro & Motil

🚨Thrilled to welcome the new #EditorialTeam at @NGMJournal led by our new Editor-in-Chief, Prof. Daniel Keszthelyi @IBS_Maastricht🎉 📢We look forward to great science & fascinating breakthroughs ahead in #Neurogastroenterology & #Motility #GutBrainScience @ANMSociety @esnm_eu

🆕🔥GI providers prescribed #RestrictiveDiets to ~20% of patients with #EatingDisorders seeking gastroenterology care‼️ 🎯Providers prescribed these diets to 16% with preexisting eating disorders—over half were not in remission💡 👉 onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

🆕🔥#TRPM8 protects against DSS-induced colitis‼️🐭 🎯TRPM8 regulates #CGRP release from sensory #neurons & IL-10 production in enteric #macrophages ⏩Revealing a protective #neuroimmune pathway during intestinal inflammation💡 👉 onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

Thrilled to share our recent #Editorial @NGMJournal🆕🔥 📢From Symptoms to Signatures: Proteome-Defined Endotypes in #FunctionalDyspepsia‼️ With Prof. @BMoshiree 🙏😇 ⏩FD patients who appear clinically indistinguishable often harbor fundamentally different mucosal programs. Some are dominated by microbial🦠-triggered #immunity in the stomach; others by type-2 inflammation, oxidative stress, or #mast-cell–neural crosstalk in the duodenum💡 🎯The next era should integrate the #Rome V multidimensional clinical profile—capturing both the lived illness experience with biomarkers revealing underlying tissue micro-organic pathology and the circuits that drive it👏 📌#Mechanism-guided, #precision neurogastroenterology offers genuine hope for novel #therapeutics that restore gut-brain🧠homeostasis. ✅ In FD, as in so many #DGBIs, the pathophysiological basis should ultimately guide treatment decisions more than symptom similarity🙌 👉onlinelibrary.wiley.com/doi/10.1111/nm…🙏😇 #Neurogastroenterology #Motility #DGBI #GutBrainAxis @ANMSociety @esnm_eu @AmerGastroAssn @AmCollegeGastro @my_ueg @RomeFoundation @GMFHx @unrmed @NYUPainResearch @MargolisLabNYU @RomeGastroPsych @GIL_trainee @IFFGD @INMAssociation @anma_i @ANGMA_AU @MRC_microbiome @ENSP_mayo @TARGID_KULEUVEN👏

Is there a potential role of proteome-defined endotypes in functional dyspepsia? @Rajan___Singh & @BMoshiree highlight the need of gaining better insights into functional dyspepsia's mechanisms of action for better therapeutic management @NGMJournal  tinyurl.com/y6fea6w3

🆕🔥Bodily Maps of #Emotions in #IrritableBowelSyndrome‼️ 🎯#IBS participants have altered embodiment of #EmotionalStates,⬆️abdominal sensations, ⬇️emotional differentiation, & blunted abdominal representation of positive emotions💡 👉onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

🆕🔥Expert Clinical #Consensus on #BodySurfaceGastricMapping Phenotypes for #Gastroduodenal Disorders: ‘Auckland Classification’ v1.0‼️ 🎯Evidence & mechanism-based treatment options are suggested for each BSGM-defined phenotype💡 👉 onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

🆕🔥#Fermented oat-based preparation ReFerm® improves colonic #BarrierFunction & modulates #Tricellulin Expression in patients with #IBS‼️ 🎯 Mechanistic insight into the barrier-protective effects of fermented oat interventions💡 👉 onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

Fermented oats reduce colonic permeability in IBS

🆕🔥Association between #PersonalityTraits & #IBS‼️ 🎯#Neuroticism appears to play a central role within a network linking dispositional vulnerability, GI-specific anxiety, abdominal pain & HrQoL💡 👉 onlinelibrary.wiley.com/doi/10.1111/nm… #GutConnectome🔁#BrainConnectome🧠 @ANMSociety @esnm_eu

🆕🔥Beyond #Malabsorption: Need for Symptom-Based Assessment in Suspected #LactoseIntolerance‼️ 🎯Breath test–proven malabsorption does not reliably predict symptoms🔥 🎯Integration of #PatientReportedOutcomes provides a more comprehensive assessment👏 👉onlinelibrary.wiley.com/doi/10.1111/nm…

🆕🔥#EntericNervousSystem organization & GI motility are disrupted in🐭fetuses with a VPA-induced #NeuralTubeDefects‼️ 🎯GI tracts from fetuses with a VPA-induced NTD contain blood🩸 👉 onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu @kaltschmidt_lab @StanfordBrain @StanfordNsurg 🎉

🆕🔥A Clinical Practice Update for the Management of Patients With #DGBI & Altered Food Intake Behavior‼️ #ExpertGuideline👏 Unmet Clinical Need 👉onlinelibrary.wiley.com/doi/10.1111/nm… #POTS #EDS #MCAS #FD #IBS #AFIB @ANMSociety @esnm_eu @AyeshaShah717 @Prof_NickTalley @GeraldHoltmann 🎉

🆕🔥Current Strategies & Future Perspectives in Management of #Opioid-Induced #Constipation: Review of International & Japanese Guidelines‼️ ⏬Dive into to learn more about most recent advances #mechanism-based early intervention💡 👉 onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu