Neil Murphy

And thanks to the brilliant @CancerGrand team at CRUK for their total support since Mutographs started, as well as wonderful scientific journey with @sangerinstitute and @UCSD colleagues (esp @drsarahmoody), partners in the 11 countries, and all the great team @IARCWHO.

1/4 Excited to share our latest preprint where we used observational and Mendelian randomization methods to explore the role of metabolites as intermediates between adiposity and endometrial cancer using data from UK Biobank (@uk_biobank). medrxiv.org/content/10.110…

📢 Think body shape not (just) #BMI #obesity subtypes & #ColorectalCancer just out in @ScienceAdvances 👏 @LPeruchet @AnjaSedlmeier @RCarrerasTorres et al. @IARCWHO #NCMTeam 🙏 @Institut_cancer science.org/doi/10.1126/sc…

The accompanying Editorial: Identifying Genetic Loci Associated with an Increased Risk for Early Onset Colorectal Cancer annalsofoncology.org/article/S0923-…

Important new study from @IARCWHO which "provides new insights into people’s genetic susceptibility to early-onset bowel cancer, as well as strengthening our knowledge of the modifiable risk factors involved, notably body weight and alcohol intake." wcrf.org/latest/news-an…

#OpenAccess in Annals of Oncology, investigators report on genome-wide association & Mendelian randomization analyses to identify causes EOCRC. 2 novel risk loci are proposed & evidence is found on the impact of modifiable lifestyle & metabolic targets annalsofoncology.org/article/S0923-… 2/2

The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally and the European cancer mortality predictions for the year 2024 published in the March 2024 issue of Annals of Oncology showed unfavorable trends annalsofoncology.org/article/S0923-… 1/2

1/9 🆕📰 Association between pre-diagnostic circulating #lipid #metabolites and #ColorectalCancer #risk New publication from @ImperialBRC @ImperialSandC Research Fellow @harewoodr & @IARCWHO et al colleagues Study funded by @wcrfint @EU_Commission doi.org/10.1016/j.ebio…

IARC scientists &partners reveal🆕findings about genetic & lifestyle risk factors of early-onset #ColorectalCancer Results may improve primary prevention, help prioritize screening 📰:@Annals_Oncology @WCRF_UK @wcrfint @Institut_cancer @CR_UK @CRUKresearch iarc.who.int/news-events/ge…

So pleased to see this important paper from @LaskarRuhina (now @EarlyCancerCam), @N_Murphy (@IARCWHO) and CORECT/GECCO consortia - GWAS & MR analyses provide insights into the causes of early-onset colorectal cancer annalsofoncology.org/article/S0923-… w/ explainer from Fred Hutch ↓

A new study co-led by Fred Hutch's @PetersRiki provides insights into what's driving #colorectalcancer in people who are often too young to qualify for preventive screening. Alcohol consumption and obesity are two important, but modifiable, risk factors. bit.ly/4c1HD72

Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer 💥The incidence of early-onset CRC is increasing worldwide. A comprehensive investigation into the aetiology of this👇 annalsofoncology.org/article/S0923-…

🔔🚨 Early onset colorectal cancer (EOCRC) 2 recent studies @Annals_Oncology and @JCOOP_ASCO ✅1️⃣Genome-wide association study and Mendelian randomization analyses ➡️6,176 EOCRC cases and 65,829 controls ➡️two novel risk loci for EOCRC at 1p34.1 and 4p15.33 ➡️a deleterious coding variant at MUTYH ➡️new EOCRC susceptibility genes: TGFβ, SMAD, BMP, and PI3K signaling, insulin signaling and immune/infection-related pathways ➡️higher levels of body size and metabolic factors (body fat percentage, waist circumference, waist to hip ratio, basal metabolic rate, and fasting insulin), higher alcohol drinking and lower education attainment > increased EOCRC risk 👉annalsofoncology.org/article/S0923-… ✅2️⃣Demographic differences and outcomes ➡️73,378 patients with EOCRC ➡️incidence and mortality rates higher in rural areas ➡️non-Hispanic Black ethnicity and uninsured patients > worse survival ➡️Married status> better survival 👉ascopubs.org/doi/10.1200/OP… @myESMO @ESMO_Open @ASCO @ASCOPost @JCO_ASCO @JCOPO_ASCO @NCIResearchCtr @theNCI @NCCN @EORTC @GlobalCRC @ColonCancerCoal @ColonCancerFdn @CCAlliance @DFarberYoungCRC @EdinUni_IGC @NCIEpiTraining @UKCGG @DrDubardGault @DenizCanGuven1 @dr_yakupergun @DrYukselUrun @yekeduz_emre @KaracinCengiz @osutcuoglu @Lynchsyndromirl @CGAIGC @OncoKB @insightmeeting @EHTG_Tweets @McVeighTerri @swatigp @meghar111 @LValleResearch @kevinjmonahan @MattYurgelun @daniela_oaks @KimmieNgMD @marklewismd @OncoAlert @oncodaily @OncBrothers @OncoViews #Cancer #Oncology #youngonset #genetics #hereditary #familial #Colon #colorectalcancer #MedX #MedTwitter

important new insights re #eoCRC #HCP - Take the time during #ColorectalCancerAwarenessMonth to learn more about #eoCRC #HereditaryGICancer

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator medrxiv.org/cgi/content/sh… #medRxiv

Incredible scenes from Tipperary today

Brilliant seminar by Richard Peto @HarvardChanSPH about the influence of residual confounding in observational epidemiological studies. Compelling actual and hypothetical examples immediately suggest sensitivity analyses explicitly for this should be /cont youtube.com/watch?v=B0Zpen…

Ultra-processed foods (UPFs) are apparently the new poison, and a recent @bmj_latest report by @rebeccacoombes suggests conflicts of interests in the “expert” views presented @smc_london that weren’t enthusiastic enough in promoting this notion. bmj.com/content/383/bm… /cont

1/10: New commentary published in Obesity this week discussing the challenges and serious biases of nonlinear Mendelian randomization (MR) methodologies: onlinelibrary.wiley.com/doi/10.1002/ob…

Come and join our Team. My time at IARC is soon coming to an end but was fortunate to be supervised by Neil!