Rene Serafini

🚨BREAKING STUDY: Intranasal Nano-Ivermectin Shrinks Brain Tumors by 70% Without Toxicity Landmark preclinical study shows intranasal ivermectin nanocapsules safely shrink glioblastoma in animal models at doses lower than the approved human antiparasitic dose 👇 📍Rats with implanted glioblastoma tumors received intranasal nano-ivermectin for 10 days at 60 µg/day — a dose below the approved human antiparasitic level. 📉Tumor volume dropped by ≈70% compared to untreated controls (79 mm³ vs 254–277 mm³). 📉The treatment also reduced necrosis, edema, and vascular proliferation, indicating less invasive and aggressive tumors. ✅No toxicity was observed — normal liver, kidney, blood, and lung histology; body weight unchanged throughout treatment. Other formulations — free ivermectin and silica-based particles — showed no significant tumor reduction, highlighting key role of nanocapsule delivery for brain targeting. These findings align with ivermectin’s 14 distinct anti-cancer mechanisms summarized by Yuwen et al, encompassing inhibition of oncogenic signaling (YAP1, Wnt–TCF, Akt/mTOR, EGFR/NF-κB, MAPK), mitochondrial and oxidative-stress induction, ion-channel modulation, and suppression of both cancer stem cells and the epithelial–mesenchymal transition (EMT). Clinical translation in humans is urgently needed.

Earlier this evening, while attending the Northern State University football game, South Dakota Republican gubernatorial candidate Toby Doeden was approached by an agitated individual. The individual proceeded to physically assault Mr. Doeden while making multiple threats on his life and repeatedly referencing his support for the late Charlie Kirk. The individual was immediately detained and subsequently arrested. We are grateful for the swift response of both the Northern State University Campus Police and the Aberdeen Police Department.