Neal Dixit, MD

A 🧵on STRONG-HF 💪🏾🫀 ⭐️The first randomized trial to show the immense benefits of a comprehensive high-intensity med-titration program with #HF GDMT ❓How did the investigators achieve an 8.1% ARR in HFH/mortality at 6 months❓ Let’s see what we can learn 👇🏾🧵

Excited to share our review on predicting sudden cardiac death in HFrEF led by outstanding med student Norayr Mkrtchyan! It's a comprehensive look at the risk factors associated with sudden death in this population @AntoinetteBirs @AHajduczok link.springer.com/article/10.100…

@ARKamathMD Come on Akshay this will certainly be an L! @drjohnm

Unbiased expert in evidence appraisal publishes interpretation of study before the actual publication is available. I thought the devil was in the details…

Is finerenone ready for primetime in heart failure? We argue that the data suggest not yet. @NealDixit @cardiologyUc #AHAJournals ahajrnls.org/3Gn7QkZ

@DrJesseMorse @GymOClockk One of the most simple yet under appreciated concepts!

@GymOClockk Not only that, the processed foods don’t cause the same level of satiety as non-processed foods

People who consumed predominantly ultra-processed foods on average consume 500 more calories than people who consume little to no processed foods.

RT @HanCardiomd: Is It Primetime for #Finerenone in #HeartFailure? ahajournals.org/doi/pdf/10.116… @CircHF #MRA

@jasonryanmd I used anki for echocardiography board review but 4 months out now I can’t say I retained much other than what I’m using for clinical practice.

Do you think residents and attendings would use Anki more if there were high-quality pre-made decks? Or do you think learning after med school is less amenable to flash cards, and requires more learning from primary sources?

Is it primetime for finerenone in HF? Would love to hear why or why not? Here is our perspective 👇🏾 ahajournals.org/doi/10.1161/CI…

Congrats @NealDixit !!! Can’t wait for you to join the awesome team at @UCSDCardiology ❤️

Ecstatic to share that I will be joining @HowieTranMD and the team at @UCSDCardFellows for Advanced Heart Failure and Transplant Cardiology Fellowship!

Is Finerenone just an expensive spironolactone? "A RCT of nonsteroidal versus steroidal MRAs is desperately needed in the HF population" Thanks for your thoughtful Editorial, @NealDixit and Saul Schaefer! @dgfn_ev @YoungDgk @MarcusSaemann @hswapnil ahajournals.org/doi/10.1161/CI…

@shahad_Chalaby 🧐

Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis | New England Journal of Medicine nejm.org/doi/full/10.10… #TCT24

Costs? Intolerance? Inertia? Other? Primary reason for gaps in #GDMTworks endlessly debated. 🤔What if we had US physicians audit their own patient charts & report *WHY* they didn’t prescribe #GDMT for #HFrEF in each case? 🚨 Results in @JACCJournals jacc.org/doi/epdf/10.10…

@AndrewJSauer HR is almost exactly the same as spironolactone in TOPCAT with Georgia/Russia excluded. Is there incremental benefit of finerenone over spiro/eplerenone? @gcfmd

#FINEARTSHF HFmrEF/HFpEF population Finerenone vs placebo Reduced primary endpoint (CVD / HF events) Looking forward to ongoing subsequent trials and analyses.

@ADiederichsen @drEdChau @DrMarthaGulati @ErinMichos @DrNathanWong @kewatson @hsbhatia @BudoffMd @rblument1 @DrMichaelShapir @gcfmd That's great, I hadn't seen that. Very clear mechanism of benefit of this screening measure!

@NealDixit @drEdChau @DrMarthaGulati @ErinMichos @DrNathanWong @kewatson @hsbhatia @BudoffMd @rblument1 @DrMichaelShapir @gcfmd Thanks for interest! Did you notice our study with 6 years of follow-up? A significant decrease in stroke and MI doi.org/10.1371/journa…

Will DANCAVAS be the most important screening trial in the last 50 years? Interested to hear opinions! Read our commentary 👇🏾 sciencedirect.com/science/articl…

Cost-Effectiveness of GDMT for HFmrEF & HFpEF jacc.org/doi/10.1016/j.… @JACCJournals #JACCHF @gcfmd @boback @mvaduganathan @NealDixit @katieptr

In #JACCHF @JACCJournals: cost effectiveness of medical tx for #HFmrEF & #HFpEF *At current cost, MRA high value, SGLT2i intermediate value, & ARNI low value *If generic, all are high value 🛑Need equitable access to meds for all!🛑 jacc.org/doi/10.1016/j.… @gcfmd @NealDixit

Generic priced options are here or just around the corner Cost-Effectiveness of Medical Therapy for Heart Failure With Mildly Reduced and Preserved Ejection Fraction | JACC: Heart Failure jacc.org/doi/10.1016/j.… @NealDixit @JACCJournals

@drscottyk I think misnomer that ASA has significantly lower bleed risk than DOAC. See from ARTESIA. Why take the bleed risk without at least getting all the ischemic protection?

Patient with Afib and Non-gender CHADSVASC less than 2. Assuming no DOAC, would you prescribe aspirin?

Should you wake up the patient when you preround? Not only is there a #kittlesonrules for that, there's also a piece in this week's NEJM. Check it out :) nejm.org/doi/full/10.10…