Sonya Neal

whoa Membrane protein solubilization and structure determination using de novo–designed proteins science.org/doi/10.1126/sc…

Congrats co-first authors @dagarwal99 and @kristyMsolorio and co-authors @eric_jordahl, @nicola_A_scott and Gayathri Ramakrishnan for putting together a fantastic review.

3/3) And the disease side: ERAD gone wrong underlies cystic fibrosis (CFTR), Charcot-Marie-Tooth (PMP22), cancer, and neurodevelopmental disorders. We also cover emerging therapeutics: PROTACs, molecular glues, and AAV gene therapy targeting ERAD substrates.

New review out in Chem Rev: "Navigating Misfolded Terrain: ER-Associated Degradation of Membrane Proteins." We loved pulling together the whole story of ERAD, from the discovery of ubiquitin to today's cryo-EM structures of ERAD machineries. (1/3)pubs.acs.org/doi/10.1021/ac…

@quinascience Thank you @quinascience🥰🥰

@Neal_Lab Exited to read. Motherhood in academia really is a journey. Thank you for this piece highlighting the challenges and how we overcome

Double announcement I'm excited to share🩷 So proud to share a new paper led by my incredible graduate student @dagarwal99 . We highlight the real experiences of mothers in academia and the structural & cultural changes needed to retain them. febs.onlinelibrary.wiley.com/doi/10.1002/18…

@cohenlaboratory Thank you Sarah!

@Neal_Lab Wow! Congratulations, Sonya!! 🍼💕

Proud of @dagarwal99 for leading this and grateful to contribute to pushing this conversation forward.

On a personal note: I’m also expecting a baby this summer! I now find myself raising 3 kids across different stages of academia (grad school, pre tenure, post tenure) while navigating the demands of this career. This work is deeply personal.

By all means, if you're deciding, take the time you need. But if you're deciding between two places, and there are three others you've ruled out, let those three know as soon as possible, not once you've picked a school You could make a huge difference to someone else's life

@bradylabupenn @ASBMB Congrats @bradylabupenn🎉🎉 Thank you paving the way🙏🏽

Grateful to @ASBMB for this extraordinary honor and to the colleagues who nominated me. This recognition means a great deal because it affirms something I believe deeply: talent is universal, but access is not.

Grateful for an incredible time at #Cardiometabolism in Keystone 🇺🇸
Honored to present our work on DRP1, mitochondrial dynamics, lipid droplets & muscle oxygenation in PAD. @KeystoneSymp @czi @officialbiohub @BWFUND @VUBasicSciences

Massive congrats to first author Saroj Gourkanti and the entire team & collaborators! So proud of this work , from CRISPR fish to live imaging to proteomics to mechanism.

New model: Rhbdl2 functions as an immune checkpoint for regeneration, restraining Rac2-dependent macrophage accumulation and preventing excessive tissue growth. This has implications for: • Chronic wounds • Fibrosis • Tumor–immune interactions Intramembrane proteases just entered the regeneration chat.

This week in Social Issues in Biology, we were honored to welcome @clairemlchapman , chair of @bummp_atucsd who shared the powerful impact of mentorship at @UCSD and facilitated amazing discussion with our students!

@drstarbird @bummp_atucsd Happy Holidays to you and your beautiful family🙏🏽🙏🏽

Happy Holidays from @Neal_Lab and @bummp_atucsd friends!!!!