Ying Cao

Ok this figure is pretty intimidating...

Cancer is not merely a problem of immunity. It's not enough to understand the fucntion of immune checkpoints in cancer merely in the context of immunity.

@WmsCInstitute Cancer is a systemic disease. Understanding a systemic disease needs understanding the rules behind. Or cancer is the manifestation of general rules dictating the animal kingdom.

Cancer is not solely a problem of mutations... not solely a problem of metabolism, not solely a problem of immunoevasion... it's problem of cellular property change, ie, loss of original cell identity&gain of neural stemness, that includes all the changes above. @WmsCInstitute

@WmsCInstitute Understanding cancer cell &cancer complexity &cancer therapy &even the inverse correlation between cancer and Alzheimer's &chemobrain... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/202…

NEURAL PROPERTY OF CANCER CELL IS THE KEY. Understanding cancer cell/complexity/therapy &even intersection of cancer hallmarks&neuroscience... as a whole by understanding neural stemness as the core property of cancer cell &rules behind cell.com/cancer-cell/fu… @Cancer_Cell

@ScienceMagazine @scisignal Cancer is a systemic disease. Understanding a systemic disease needs the understanding of systemic rules. Or cancer is the manifestation of the power of the general rules dictating the animal kingdom.

The emergence of AI tools is not only helpful in cancer #neuroscience, but may be a necessary step to decode the highly complex networks that connect cancer cells to the nervous and immune systems, researchers argue in a new @SciSignal Focus. scim.ag/4rtKrQT

@ScienceMagazine @scisignal Understanding cancer cell &cancer complexity/therapy &even the inverse correlation between cancer and Alzheimer's &even cancer-nerve crosstalk ... by understanding neural stemness as the core property of cancer cell &rules dictated by neural stemness. preprints.org/manuscript/202…

@ScienceMagazine @scisignal Host nervous systems promote cancer. For cancer therapy, it is better to block the host nervous system on cancer or it is better to block the neural property of cancer cell itself? So, blocking host nervous systems or neural property of cancer cells? That's the question.

@ScienceMagazine @scisignal

@MSKCancerCenter @KarunaMDPhD @CancerGrand Cancer is a systemic disease. Understanding a systemic disease needs the understanding of systemic rules. Or cancer is the manifestation of the power of the general rules dictating the animal kingdom.

"We hope to convert advanced colorectal cancer into a manageable disease." #ICYMI: MSK physician-scientist @KarunaMDPhD and colleagues were awarded a @CancerGrand grant — a prestigious global initiative providing up to $25 million over five years to tackle some of the toughest problems in cancer research. Learn more: bit.ly/4d1GX4p

@MSKCancerCenter @KarunaMDPhD @CancerGrand ∵the core property of cancer cell is neural stemness, which confers cancer cell with pluripotency. ∴cancer cells can be induced to differentiate like ESCs. ∴any major embryonic non-neural lineage differentiation factors can rewire cancer cell into a vulnerable state.

@MSKCancerCenter @KarunaMDPhD @CancerGrand Understanding cancer cell &cancer complexity &cancer therapy &even the inverse correlation between cancer and Alzheimer's &... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/202…

When you talk about cancer cells, cancer stem cells, tumor cells,... what the hell are you talking about?

As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. ABCC1. They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells and unifies cancer cell phenotypic traits incl. resistance.

Try something else. The chance couldn't be worse.🤣 Suppression of Cell Tumorigenicity by Non-neural Pro-differentiation Factors via Inhibition of Neural Property in Tumorigenic Cells frontiersin.org/journals/cell-… (sorry it's just in a predatory journal🙄☹️)

Cancer is not solely a problem of immunity. not enough to understand the function of immune checkpoints in cancer merely in the context of immunity. understanding neural stemness as the core property of cancer cell&the rules dictated by neural stemness. preprints.org/manuscript/202…

@newstart_2024 Cancer is a systemic disease. Understanding a systemic disease needs understanding general rules behind. Or cancer is the manifestation of general rules dictating the animal kingdom.

Dr. Patrick Soon-Shiong to Megyn Kelly: For 75 years we've treated cancer like a war—nuking tumors with poisons (chemo) and radiation while simultaneously destroying the immune system's natural killer cells and T-cells. The vicious cycle: Chemo → anemia → give Epogen → more chemo → wipe out neutrophils → give Neupogen → more chemo → destroy more lymphocytes/NK cells. FDA's gold standard? Maximum Tolerated Dose (MTD) — push the poison just below what kills the patient, measure tumor shrinkage (response rate), but ignore overall survival. Soon-Shiong: “The tumor shrinks… but the patient dies. We’re not really interested in overall survival as an endpoint. That is today’s thinking.” Megyn Kelly: “It seems to be a willing choice because we’ve gone so long without making much progress.” Clip from this 2:33 bombshell — the cancer “war” paradigm laid bare. Is MTD + response-rate obsession the reason we’re still losing the fight? Or is this the best we’ve got until something radically better arrives? Your take—seriously, drop it below.

@newstart_2024 Understanding cancer cell &cancer complexity/therapy &even the inverse correlation between cancer and Alzheimer's &even chemobrain... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/202…