Nils Walter Lab

@NilsWalterLab: Exciting to work in a dynamic, collaborative & creative team @UMich @umichLSA @MichiganChem @UMBiophys, embedded in the large @umichrna Center. Fun to learn together modern RNA biology & RNA medicine & single molecule microscopy in top-5 place to live @AnnArbor!

✨Excited to share that our Nanodomain paper is finally published on @NatureNano! We probed the internal organization of FUS #condensate via #SingleMolecule tracking and found nanodomains that constrain the protein and #RNA diffusion and thus tune local biochemistry. Repositioning of nanodomains towards condensate periphery might seed and thus explain aging-induced protein fibrillation. Nanodomain properties are regulated by guest molecules, including small-molecule ALS drugs, even at very low concentration. Taken together, this #research shows that the nanoscopic world inside a condensate is vivid, and the intra-condensate dynamics could elucidate foundational aspects of condensate biology/pathology. t.co/NDvsrEEnyR This is a nice collaboration with again our talented @em_sumrall at @NilsWalterLab @UMBiophys @umichrna! Huge thanks for everyone who has helped us throughout this journey!!

U-M students free ticket promotion while tickets last, send an email from your umich account to info@uncommonproductions.com

Look for yourself: nature.com/articles/s4159…

Congrats to former graduate student Jieming Li, Leyou Zhang and long-term senior scientist Alex Johnson-Buck on this milestone for the single molecule field! More discoveries to be made using this versatile online tool @UMich @umichrna @umichLSA @MichiganChem @UMBiophys

pubmed.ncbi.nlm.nih.gov/40972943/ ✨Another paper just out at @JMolBiol (co-first with our talented Emily Sumrall again!) @NilsWalterLab @UMBiophys In short, we realized that tethering is critical to correctly measure sub-diffusion within a condensate via #SingleMolecule tracking, especially for long RNAs. This work laid the foundation for our discovery of nanodomains within FUS condensates (pubmed.ncbi.nlm.nih.gov/40291709/).

Great day at @UMichMedSchool's Researchpalooza event yesterday! Damon Hoff talked up @umichrna's SMART Center core facility, and all things #RNA, #DNA, single-molecule imaging, and beyond. @NilsWalterLab

Honored and excited to present on our work on biomolecular condensates at Sydney Symposium in November: sydney.edu.au/engineering/sc… Great lineup of speakers! @umichrna @MichiganChem @UMBiophys

Very honored & delighted to present a talk at A-RNA 2025 in Sydney, Australia, about Life in Eternal Flux as exemplified by RNA-protein complexes: a-rnameeting.org.au Great lineup of speakers!

I'm so grateful to this award and all the solid training I got from @NilsWalterLab and @UMBiophys !! Will keep going with I have learned here! Go blue!

Let's celebrate both past achievements and future promise--Guoming Gao (Krimm dissertation awardee) mentee and current Walter lab graduate student Bisal Halder just passed his Chemistry gateway exam with flying colors--Congrats Bisal!!

Congrats to former Walter lab graduate student Guoming Gao on Krimm Dissertation Award of Biophysics at the University of Michigan for his dissertation "Probing the Impact of Biomolecular Condensates on RNAs with Single-Molecule Tracking in vitro and in cellulo"--Well-deserved!

Thanks @AdrienChauvier for all the incredible support and innovation you contribute to the @NilsWalterLab every day! @umichrna @umichLSA

📢JOIN US LIVE Wednesday, April 9, 4 PM ET! We're co-hosting the @RNASociety RNA Collaborative Seminar Series with @UR_Med, featuring talks by Ph.D. candidate Grace McIntyre @DiFeoLab and @NilsWalterLab Senior Scientist @AdrienChauvier Zoom registration 👉us02web.zoom.us/webinar/regist…

Join us in taking the next life-changing steps to bring #RNA Therapeutics to @UMich. Your involvement can make all the difference.! #GivingBlueday maizeraise.umich.edu/schools/Univer…

Congrats to Dr. Adrien Chauvier from the @NilsWalterLab for receiving the well-deserved 2025 Research Associate Recognition Award from the @UMichResearch Office of the VP for Research! Adrien truly shows exceptional performance and goes the extra mile! @umichrna @MichiganChem

Thanks for inviting me to speak & cordially welcoming me to the Lorne Genome conference 2025–@Australia has great science, friendly people, and a commitment to innovation! What an enjoyable & stimulating sabbatical at @UNSW in @cityofsydney and beyond! @umichrna @MichiganChem

👩‍🏫Want to present your work? 📜Now accepting abstracts for the 2025 RNA Symposium March 6-8, 2025 @UMich 🚨SUBMISSION DEADLINE JANUARY 20! ⏰Early registration ends December 31 -SPACE IS LIMITED! ☑️Submit an abstract ☑️Register ☑️Be a sponsor Visit conta.cc/3YEx1VZ

Happy Holidays to all from the @NilsWalterLab - Cheers to a successful year with great papers, much camaraderie, shared ups and downs (more ups!), White Elephant gifts, and support from such a diverse group! To more such years! @MichiganChem @umichrna @UMBiophys @umichmedicine

CONGRATS to *Dr* Emily Ellinger - cheers to a well-deserved PhD, making it through the pandemic and onto exciting papers on riboswitch function and therapeutics! @MichiganChem @umichrna & Biological Chemistry in @umichmedicine @UMPIBS

In @ScienceMagazine - great collaborative work w/ @AlbertW_Lab & @RappsilberLab showing that bacterial RNA polymerase can thread nascent mRNA into the pioneering ribosome from two sides for higher translation initiation efficiency - target for antibiotics? eurekalert.org/news-releases/…