Oliver Drozdowski

📝 New preprint! 📝 Happy to share a new preprint from @KimBoonekamp and me: We developed a 3D force inference method for budding organoids! biorxiv.org/content/10.110… From the labs of @SchwarzUlrich and @Michael_Boutros with help from Ulrike Engel. Here the details.

This study applies active gel theory to myosin isoforms to demonstrate their complementary roles for #CellMigration, highlighting the importance of isoform-specific molecular details to understand behavior of the whole cell. Check it out: go.aps.org/47giRQG

📢 Preprint alert 📢 (1/6) Our work on 3D force inference for intestinal organoids is now on bioRxiv: biorxiv.org/content/10.110… Stunning collaboration between @OMDrozdowski and @KimBoonekamp from the lab of @Michael_Boutros and with Ulrike Engel. A short🧵...

This work was my main PhD project @UniHeidelberg and @mattertolife. I am proud that we can present it now! If you are interested, please check out our preprint on bioRxiv: biorxiv.org/content/10.110…

So can we find a signature of this effect in our inference? Yes. We introduce line tension inference and find that apical and basal line tensions seem to be increased. Especially the basal line tensions can only be explained through additional intracellular physics.

📝 New preprint! 📝 Happy to share a new preprint from @KimBoonekamp and me: We developed a 3D force inference method for budding organoids! biorxiv.org/content/10.110… From the labs of @SchwarzUlrich and @Michael_Boutros with help from Ulrike Engel. Here the details.

Spring brings new beginnings.. Happy to start my new position @ISTAustria as a post doc with @EdouardHannezo. Looking forward to learn new things and study new problems in the realm of multicellular structures. Also: Vienna is beautiful.

📢Paper alert📢 Our joint work with the group of Peter Bastian on the positioning of stress fibers in mechanically challenged cells is now out in the Journal of the Mechanics and Physics of Solids. This work was challenging, so it deserves a 🧵 for explanations ... (1/n)

Great theory work by @OMDrozdowski who compared the classical with the bubbly vertex model and found that the latter naturally leads to cell bulging and extrusion at topological (pentagonal) defects. He then developed an analytical theory for the corresponding energy landscapes.

O. M. Drozdowski, U. S. Schwarz, Cell bulging and extrusion in a three-dimensional bubbly vertex model for curved epithelial sheets. arXiv [physics.bio-ph] (2024). arxiv.org/abs/2411.07141

Congrats to newly minted Dr. Oliver Drozdowski @OMDrozdowski for a very successful defense of his PhD-thesis. And thanks to @tristanbereau for being chair of the committee and to the whole group for the lovely hat.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

Congratulations to @LeonLettermann for winning this year‘s Klaus Arnold publication prize by the German Biophysical Society #DGfB #DGfB24 for his recent paper in @PNASNews on a geometrical theory for gliding motility 👍🎉🥇

Great news📢! A new technique that can precisely influence the development of organoids has been developed by an interdisciplinary team, including @KGoepfrich💪 DNA microbeads are the crucial tool. Check out more: mr.mpg.de/14602068/compl… and of course nature.com/articles/s4156…

check out the new paper from our lab with @KGoepfrich and @SchwarzUlrich groups where we put DNA microbeads for precise signal control in #organoids. doi.org/10.1038/s41565… @AftingCassian @c_schlagheck @Cluster3DMM2O

Also please check out the press release by @UniHeidelberg: uni-heidelberg.de/en/newsroom/ne…. I hope this experimental technique will facilitate the development of even better organoid models in the future! Thanks to the labs of @KGoepfrich and @WittbrodtLab for the nice collaboration.

Very happy to have contributed to this ingenious project by 1st authors @ToWalther & @AftingCassian (rdcu.be/dTEb1) with some theory and analyses on diffusing morphogens. If you are interested in the 3D FEM model behind the work, check the details in the SI.