Oligowizard

Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences All now oligowizard.com !

Here we go! #OTS2025

Our database on approved nucleic acid therapeutics is online: oligowizard.com/wiki/ Let us know what you think, and do get in touch if you’d like to contribute!

The issue is finally fixed! Thank you for your patience!

We are currently experiencing problems with the SSL certificate for oligowizard.com. You can still reach the site via http rather than https. We are looking into fixing this issue as quickly as possible - apologies for the inconvenience!

The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at: oligowizard.com/structures/ #oligotherapeutics #RNA #oligos

New FDA GUIDANCE on 'Nonclinical Safety Assessment of Oligonucleotide-Based Therapeutics': fda.gov/regulatory-inf…

Time for the #OTS24 awards session! Congrats @OTSociety poster winners!

Prof Steve Dowdy wrapping up the delivery session. How do we tackle the 800 pound gorilla that is endosomal escape? #OTS #OTS2024 #oligomeeting

@DrMikeBooth They really are!!

Nucleic acids are pretty cool, right!?

Excited for the next gen session hosted by trainee representatives Eva-Maria Manz of ETH Zürich and Jathavan Asohan of McGill #OTS24 #oligomeeting #OTS

Here we go! #OTS24 #oligomeeting #oligotherapeutics

@CMordstein Christine, thanks for the complement! OW is run by @JPhilBecker. The project is still very much under active development - there are new features every few months!

Hey @Oligowizard . Who built you and why didn't I come across you earlier? You're cute 😉

THE DEADLINE FOR MENTORSHIP APPLICATIONS IS TODAY! Mentor-mentee matches are completed by mid-August. Don't miss this chance! Apply today! oligotherapeutics.org/the-mentorship… #OTS #oligotherapeutics #oligonucleotides #science #research #mentorshipprogram #oligoresearchers #sciencecareer

Great paper! But what happened to the pyrimidine N1 Nitrogen? 😉

@jptosar We think that gymmosis is largely driven by increased protein binding of oligos containing phosphothioates. Modified oligos such as nusinersen happily enter the cell but struggle to escape the endosomes. Here increased nuclease stability might allow them to form a leaky depot

3) Gymnosis is not an ASO-specific mechanism... It's how cells sense naked or nonvesicular exRNAs. Modified bases or LNPs do, in addition to other tricks, what we did with RI here: protect exRNAs from degradation!

📌Preprint alert! Can naked extracellular RNA enter cells? Can it escape from endosomes into the cytosol? Can naked extracellular mRNAs be translated if not encapsulated in EVs or LNPs? Why do we have so many RNases in the blood? 🤔 A thread 🧵🪡 biorxiv.org/content/10.110…

We’re celebrating our first mention in the scientific literature 🥳 Work by @alyssa_hill et al. in @ACS_Omega used oligowizard to calculate the properties of their (maleimide-modified) oligos! Check out their paper below: pubs.acs.org/doi/10.1021/ac…

Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics Here’s a teaser: 🧵

Let’s go! #OTS #OTS23 #oligomeeting

Great talk at @ETH by @DrMikeBooth on #oligonucleotides and how they can be turned into light-sensitive switches!