Phil Becker

46 posts

Phil Becker

@JPhilBecker

Biochemist working on therapeutic oligonucleotides. Currently doing a postdoctoral fellowship at UMass Medical School

Massachusetts Katılım Mayıs 2020

214 Takip Edilen99 Takipçiler

Phil Becker@JPhilBecker·26 Mar

Hot off the press: Excited to share a fantastic review from our very own @WellerCelly, just published in CHIMIA! "Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins" Check out the full review here: doi.org/10.2533/chimia…

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Phil Becker@JPhilBecker·18 Kas

This one goes out to all the oligo chemists - we made the chemdraw feature public and added a few new functions here and there. Check it out!

Oligowizard@Oligowizard

The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at: oligowizard.com/structures/ #oligotherapeutics #RNA #oligos

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Phil Becker@JPhilBecker·7 Eki

At the 2024 OTS meeting in Montreal!

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Phil Becker retweetledi

Oligowizard@Oligowizard·29 Eyl

Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences All now oligowizard.com !

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Phil Becker@JPhilBecker·5 Tem

@CVRinfo @CVRHutchinson Wow that's great - congratulations, Ed!

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MRC-Uni of Glasgow Centre for Virus Research@CVRinfo·5 Tem

Congratulations to Ed Hutchinson who has been promoted to Professor! Find out about Ed's research: gla.ac.uk/research/az/cv… @CVRHutchinson

MRC-Uni of Glasgow Centre for Virus Research tweet media

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MRC-Uni of Glasgow Centre for Virus Research@CVRinfo·5 Tem

NEW | Massive congratulations to the CVR staff members who have been promoted this week! 🎉 #AcademicPromotions

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Phil Becker@JPhilBecker·5 Haz

@JorgStulke @VAAM_Microbes Looks great! Say hi to @RNATobi from me!

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Jörg Stülke@JorgStulke·4 Haz

Hello from picturesque Würzburg! Really enjoyed my #Schäufele! Franconia’s food @VAAM_Microbes

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Phil Becker@JPhilBecker·3 Haz

@BriggsGroup @jpeukes @bio_physics Looks great!

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John Briggs@BriggsGroup·3 Haz

A physical model for M1-mediated influenza A virus assembly. A combination of #cryoEM and theoretical modelling from @jpeukes and @bio_physics. Preprint here: biorxiv.org/content/10.110…

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Phil Becker@JPhilBecker·1 May

@AmandaZihanZhu @nicole_robb1 @CVRHutchinson Amanda, congratulations on your successful DPhil! Well done!! 🥳

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Amanda Zihan Zhu@AmandaZihanZhu·1 May

This a post entirely devoted to thank my amazing examiners: Nicole @nicole_robb1 and Ed @CVRHutchinson who have drawn the perfect full stop to my DPhil journey. It was my greatest pleasure to have spent one of the most interesting and brain-stimulating 3 hours with you!!

Fodor Laboratory@fodorlab

Massive congratulations to Dr @AmandaZihanZhu for passing her DPhil viva! Thanks to Ed Hutchinson @CVRHutchinson and @nicole_robb1 for being the examiners and thanks to the llama for the influenza virus polymerase nanobodies!

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Phil Becker retweetledi

Swiss RNA Therapeutics Summit@RNATX_CH·20 Ara

Register Now & Submit Abstracts for the 2nd Swiss RNA Therapeutics Summit, January 25, 2024, @unibern. rnatx.ch @Roche @kanton_bern Economic Development Agency @C_Leumann @PNioi @MartinJinek @snsf_ch @ETH_en

GIF

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Phil Becker@JPhilBecker·25 Eki

The Jonathan Hall lab @ETH_DCHAB @ETH_en had a fantastic time at the #oligomeeting #ots23 by the @OTSociety !! Four days of fantastic talks and stimulating exchanges! Huge congrats to Mathilde Vincent @mathilde9v and Štefan Moravčík for winning the poster prizes!

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Phil Becker@JPhilBecker·25 Eki

Lots of phenomenal exchanges and ideas at #oligomeeting #ots23 hosted by @OTSociety ! Thanks to everyone for the great discussions; and thanks to the OTS for the travel grant!!

Phil Becker@JPhilBecker

Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics Here’s a teaser: 🧵

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Phil Becker retweetledi

AnnemiekeAartsma-Rus@oligogirl·24 Eki

LAA discussion went to controls ⁦@OTSociety⁩ #ots23 As ⁦@F_ANAtico⁩ mentioned there is a great review about this inspired by work from both winners Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs - PubMed pubmed.ncbi.nlm.nih.gov/30907681/

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Phil Becker@JPhilBecker·23 Eki

Check out P149 by @EvaMariaManz2 to learn about base editing to treat the EPP SNP, P167 by Štefan Moravčík on selective/chemical RNA methylation, P235 by @mathilde9v on the influence of PS linkages on oligo-protein interactions, and P239 by @WellerCelly on RNA PROTACS!

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Phil Becker@JPhilBecker·23 Eki

But can we reproduce this splicing correction in our new vivo model? Come and find out at P23 tonight! Big thanks to @NCCR_RNADisease and @snsf_ch for funding the project! I’m also very grateful to @SwissChemistry and @SCNATChemistry for the chemistry travel award!!

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Phil Becker@JPhilBecker·23 Eki

Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics Here’s a teaser: 🧵

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Phil Becker retweetledi

Alyssa Hill, PhD@alyssa_hill·19 Eki

In new work resulting from a collab. with @Roche, we show peptide conjugates of an #ASO 🧬 are inactive in cells due to endosomal entrapment. Getting #oligos into cells is only half the battle - the next question is how do we get them out of endosomes? ⭐️ doi.org/10.1021/acsome…

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Phil Becker retweetledi

Oligowizard@Oligowizard·16 Eki

Great talk at @ETH by @DrMikeBooth on #oligonucleotides and how they can be turned into light-sensitive switches!