Pascal Chappert

Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem @InstitutImagine @UnivRennes1 authors.elsevier.com/a/1fnZ73qNrUqF…

@CellPressNews @NeckerInem @casanova_lab @GorochovG @institutpasteur This silent autoimmune state, revealed upon viral infection, may affect ~0.4% (<70 yrs) to 4% (>70 yrs) of the population and represents a common and global determinant of severe viral disease.

@CellPressNews @NeckerInem @casanova_lab @GorochovG @institutpasteur Our data support a model where T-cell tolerance breakdown drives a germinal center B-cell response against type I IFNs, months to years before severe viral infection.

🚨 Proud to share our new study in @CellPressNews: B cells producing auto-Abs that neutralize type I IFNs in severe viral infections. Work from AI2B_lab @NeckerInem, @casanova_lab, @GorochovG and Rey’s labs @institutpasteur. doi.org/10.1016/j.cell…

Online now: SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals dlvr.it/StKFk6

Des scientifiques ont découvert comment l'infection par le variant #Omicron BA.1 remodèle la mémoire immunitaire chez des patients vaccinés, améliorant ainsi les capacités des cellules mémoires à reconnaître le #SARSCOV2 et à le neutraliser.⤵️ presse.inserm.fr/linfection-par…

Une équipe de recherche a analysé la mémoire immunitaire après infection par le variant Omicron BA.1 chez des patients vaccinés avec trois doses du vaccin COVID-19 à ARN messager. aphp.fr/contenu/linfec…

🔬Our new article is now online at @ImmunityCP ! We analyzed how memory B cell repertoire is remodeled by Omicron breakthrough infection💉🦠🧫! Great collaborative work! @NeckerInem @institutpasteur @APHP @IMRB_Mondor @PChappert @MahevasMatthieu cell.com/immunity/fullt… 👇🧵

Overall, our results imply that separate mechanisms such as early telomere elongation, affinity selection during the contraction phase and access to a specific niche contribute to ensuring the functional longevity of MBCs.

Instead, these long-lived MBCs appeared enriched in a CD21hiCD20hi IgG+ splenic B cell subset displaying a marginal zone-like NOTCH/MYC-driven signature and harbored long-lasting elongated telomeres.

Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem @InstitutImagine @UnivRennes1 authors.elsevier.com/a/1fnZ73qNrUqF…

Diversity is the key! Our new pre-print shows that the diversity of their repertoire allows memory B cells to control SARS-CoV-2 variants. Thanks to all for this collaborative study! @NeckerInem @institutpasteur @IMRB_Mondor biorxiv.org/content/10.110…