Emily Chen

@MagnusPalmblad @PaoloBonini6 Turnover rate might slow down and quantity reduced🤣

@PaoloBonini6 In addition, aren't most plasma proteins turning over within a few weeks anyway, or have a half life measured in weeks rather than years? In other words, isn't a 101-year old's plasma is just as fresh as that of a 1-year old?

Replacing plasma and claiming to reverse aging based on proteomic clocks is a fundamental misunderstanding of how predictive models work. These models estimate biological age using correlations, not causation. Proteomic aging clocks rely on biomarker patterns observed in the data they’re trained on. Changing those biomarkers may alter the clock’s output, but it doesn’t mean you’ve actually reversed the biological processes of aging. Correlation ≠ causation. Biomarkers in these models are predictors of aging, not necessarily drivers of it. Manipulating them might ‘fool’ the model, but that doesn’t guarantee any real impact on the underlying biology. Don’t confuse model-driven estimates of age with real biological change. Predictive tools are useful but limited. Reversing aging requires more than tweaking markers—it demands understanding and addressing root biological mechanisms.

@MagnusPalmblad Any recommendations?

Tasting Spanish wines in Barcelona. Perfect activity for a day like this.

@J_my_sci It’s a starting of the mental tug of war to see who wins😂.

@ProteomicsNews @neely615 @timp0 Thank you for saying what I have been saying along. We need to think bigger and communicate better with the rest of the scientific community.

@neely615 Got it. You will be happy to go to work😂.

@neely615 Why? There are more pros than cons. We are more flexible to structure our days and time. I got more breaks and exercise done as well.

@UCDProteomics @mjmaccoss @J_my_sci @JohnRYatesIII 😂

@mjmaccoss @J_my_sci @JohnRYatesIII coyotevest.com Plus your doggo will look like he/she is in a madmax movie!

@neely615 @UCDProteomics @labs_mann I am really confused about the whole deal with 23andMe. I hope the database it has built so far will be put to good use.

@EveHayes123 There you go! I don’t think you missed much.

We’ve taken ourselves out for dinner instead.

I’m at a conference today. The organisers just told me that I can’t bring my daughter to the networking session or the dinner tonight. I couldn’t get a babysitter. This is one of those times, as a single parent, that you really miss out. It felt like a gut punch.

@J_my_sci Awesome!

@neely615 You can cook!

@MagnusPalmblad @chrashwood I bet many people will quit instead!

@chrashwood What if we remove all the oxygen from the lab and have the lab staff wear SCBA gear?

@pwilmarth I get you. Like any new technology, it attracts a lot of attention. I hope we will see some joint adventures of combined domain expertises. Otherwise, it could be a waste of time, efforts, and resources.

@pwilmarth What do you think the Al can make the biggest impact on mass spectrometry??

@thejustinmecham Thank you for letting the secret out of the bag!

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@neely615 @seejbrown @ProteomicsNews @edward_marcotte Did he talk about how challenging to produce a commercial prototype?

Interesting Proteomics Paper -- still a few years off, but really cool to see Edman Deg back again! @ProteomicsNews and @neely615 podcast made me go look for a paper on the Illumina version of Edman Deg! nature.com/articles/nbt.4…

@J_my_sci @byu_sam @slavov_n @NIH That RFA was out three years ago. Any idea what technology received the award?

Dear @NIH, Thank you for providing 13.8 Billion USD to NHGRI for advancing genomics research. Have you considered supporting the advancement of proteomics research ? nih.gov/about-nih/what…

@byu_sam @neely615 Totally agree! Focus on what is real.

@neely615 probably me. I have spent a lot of time pondering contentedness. My goals in career are different now than at the beginning. I'm also trying to be happy in what I have now, and not consumed by a desire for 'more'

@PhDVoice @PostdocVoice Servant leadership training.

What is a way you wish academia would change? #PhDVoice @PostdocVoice