Pedro Manuel

@pepeheffernan @DanGrahamMD There are some paranuclear vacuoles also

@DanGrahamMD There are macrophages with ink. GIST, digestive tract

Organ? Dx? #PathX #PathTwitter

@AssessaEss25523 @FatimaShamsPath Ck20 and CDX2 are staining the normal colonic mucosa! It is in fact CK7 PAX8 WT1 ER positive and p53mut

@FatimaShamsPath “Carcinomatous proliferation, likely metastatic. Immunohistochemical markers: CK7, CK20, CDX2, and estrogen receptor.

👉 70 YO female presenting with abdominal mass. Colonoscopy showed two large sigmoid masses. What is your diagnosis? Any further work-up/IHC? #PathTwitter #GIpath #Surgpath #Pathology #Pathresidents

@kis_lorand GG3

#GUpath colleagues do you consider this pattern of prostate carcinoma GG3 or GG4? #pathtwitter #pathology

@raquelbarron It is amazing how even with a TA you can learn so much :D

@PathologyPedro Yes! I was also surprised when I reviewed PathologyOutlines; it's in the chapter on fibroepithelial tumors. 🙂 Thanks.

Breast, fibroepithelial tumors 🔬❤️ Tubular adenoma #pathology #breast

@raquelbarron Apparently they are somewhat related, the term 'fibroadenoma with pericanalicular pattern' were used in the past for TA, but it is not recommended by WHO anymore. In the bluebooks it is in a chapter different from fibroepithelial tumors, but I guess there is some overlap hahaha

@Gloria_SuraMD Epithelial myoepithelial carcinoma? It looks like there are two layers of cells in the tubules

Resection of a parotid gland mass revealing what type of tumor? Answer: buff.ly/fOvoSPB #PathArt #PathTwitter #MedTwitter buff.ly/hpglxhh

A #pathology classic! Fresh tissue touch prep. What's your diagnosis? Answer ✅ youtu.be/yB24r0iAWDs?si… #Pathology #dermpath #dermatology #dermatologia #dermtwitter #BSTpath

#PathTwitter #nephropathology #kidney

What stain comes next? New pics after the poll

67yo male with nephrotic syndrome. This is what you find in kidney biopsy. What's your next stain?

Summary findings and dx approach to giant cell rich tumors of bone in small bx samples. ➡️ If prominent xanthomatous change, if CK+ think of xanthogranulomatous epithelial tumor (XGET) ➡️ RNA seq highlights characteristic HMGA2::NCOR2. Dr. Silvia Bagué #BSTPath #HMar_BASTPC25

@DanGrahamMD Schwannomas can be challenging if you are not familiar with it's many faces!

40s M lower leg mass. Dx? #BSTpath #PathTwitter #PathX

New in #HumPathol: TFE3-Rearranged Ossifying Fibromyxoid Tumors are Uniquely Negative for Glycoprotein Non-Metastatic Melanoma Protein B: A Study of 13 TFE3-rearranged Mesenchymal Tumors. sciencedirect.com/science/articl… #pathology #PathTwitter #PathX #BSTpath

LVI or not?

A cluster of malignant squamous cell dissecting the muscular wall of a blood vessel. The lumen shows a fibrin thrombi, without cancer cells (at least in this section). Does it count as vascular invasion or not? #PathTwitter

Is there and immunohistochemical technic that helps in this setting? (Bonus picture later on)

What other clinical/laboratory finding would you request for the clinician?

61 yo male with nephrotic syndrome and bilateral heart hypertrophy. A kidney biopsy was performed. #nephropathology #pathology #PathTwitter #pathresident