Pavithran Ravindran

227 posts

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Pavithran Ravindran

Pavithran Ravindran

@PavithranRavind

CD3 at UPenn MSTP program. Former technician at Princeton University and UCSF. Interested in synbio, systems bio and cancer biology.

Pennsylvania, USA Katılım Haziran 2018
410 Takip Edilen326 Takipçiler
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Pavithran Ravindran
Pavithran Ravindran@PavithranRavind·
We are published! Check out the full paper here: authors.elsevier.com/c/1e13B8YyDffJ…. We added some fun analysis of our endogenous Erk signaling data and fleshed out tunable versions of our circuit design. Please DM if you have any questions, always happy to chat!
Pavithran Ravindran@PavithranRavind

Super excited to present the work I have been doing since graduating! Here we demonstrate a new approach to studying signaling dynamics by labeling pulsing cells with a synthetic gene.

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Lingting Shi
Lingting Shi@shi_lingting·
Tumor immune evasion is programmable🛡️🧠. Our integrated single-cell CRISPR screening framework maps kinase control of T cell–driven tumor states in Glioblastoma(GBM) 🧬and nominates druggable nodes 💊 (e.g., EPHA2/PDGFRA) that blunt evasive programs and boost T cell killing 🔥.
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Pavithran Ravindran
Pavithran Ravindran@PavithranRavind·
Check out this incredible work from my fiancée's PhD!! Everyone is trying to sequence more cells x conditions x genetic perturbations, but sequencing becomes prohibitive. Here, she and her co-authors describe a method to sequence just the parts of the transcriptome that you need!
Mathini Vaikunthan@MathiniVai

Excited to share some of my PhD work! Here we present Targeted Reverse Transcription-Linker (TRTL), a modular method for scalable, targeted, combinatorial single-cell RNA-seq: biorxiv.org/content/10.648…

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Jose L. McFaline-Figueroa
Jose L. McFaline-Figueroa@joselmcfaline·
We’re hiring!📣 Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825
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Akanksha Thawani, PhD
Akanksha Thawani, PhD@AkankshaThawani·
🚨 Extremely excited to share that I’m joining @Columbia University as an Assistant Professor! The Thawani Lab will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. We’re hiring at all levels! If you're interested in transposons, genome biology, cryoEM, RNA, chromatin, or tool building—let’s talk! Particularly interested in enthusiastic technicians and postdoctoral fellows @ColumbiaBiochem #NewPI #RNANEWS
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Mo Khalil
Mo Khalil@MoKhalilLab·
Years ago, we set out to create synbio tech to solve a major challenge: generating precision antibodies for challenging membrane proteins. It's a DREAM COME TRUE to report we've now launched K2 Therapeutics (k2-tx.com) to advance this into transformative medicines
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Pavithran Ravindran
Pavithran Ravindran@PavithranRavind·
Tour de force from @shi_lingting taking a multi modal approach to study GVHD! The T reg rewiring finding is particularly cool! Check out the work on biorxiv!
Lingting Shi@shi_lingting

I just presented my work at the @KeystoneSymp Single Cell Biology-where we tracked how human T cells evolve across time and space during #GVHD. And it changes everything. 💡 It’s not just infiltration—T cells adapt and shift phenotype as they migrate through tissue. bioarxiv 👇

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Grant Kinsler
Grant Kinsler@GrantKinsler·
Excited our work is out today in PLOS Biology! We find that, over 2 steps of evolution, mutations shift from improving 2 traits at once to 1 at a time. This suggests that mutations that improve many traits are rare. journals.plos.org/plosbiology/ar…
Grant Kinsler@GrantKinsler

Do the mutations that drive evolution improve many traits or few? How might this change over the course of evolution? Excited to share our new work exploring these questions in the first 2 steps of adaptation w/ @liyuping927 @gsherloc @PetrovADmitri 🧵1/n biorxiv.org/content/10.110…

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Daniel Bryan Goodman
Daniel Bryan Goodman@dbgoodman·
Big news! 🥳🥂 In July 2025, I will be joining the faculty of University of Pennsylvania, @Penn_CBIO. The Goodman Lab for Synthetic Immunology will combine synthetic biology, genome engineering, and ML-driven functional genomics to study and manipulate primary immune cells. 🧵1/3
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Harry McNamara
Harry McNamara@h4rrymcnamara·
a personal update: in January, I'm moving to Yale to join @MCDB_Yale and to open my lab in the @WuTsaiYale Institute! We will investigate multicellular self-organization using synbio tools to read and write developmental signals in stem cell models. syndevbio.org
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CHOP Research
CHOP Research@CHOP_Research·
Congrats to @ChildrensPhila's Dr. Evan Weber, recipient of the @NIHDirector's New Innovator Award! Dr. Weber will pursue a novel approach to reprogram T cells with enhanced tumor killing function, paving the way for more efficacious #cancer therapeutics. @CHOPCancerCntr
NIH Common Fund@NIH_CommonFund

Early-stage investigators proposed #innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: commonfund.nih.gov/newinnovator/A… #NIHHighRisk

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Harry McNamara
Harry McNamara@h4rrymcnamara·
Our study decoding gastruloid symmetry breaking is now live @NatureCellBio! rdcu.be/dVMLG Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):
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Majo Duran
Majo Duran@majo__duran·
Met most of you during my time in SF, arriving with nothing but motivation and passion for science. I gave it my all, and I still can’t believe where it’s taken me! In 6 years, I became the first Latin American who studied in LATAM to reach MIT Bioengineering. The dream begins❤️‍🔥
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William Gibson
William Gibson@wgibson·
TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
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Jessi Li
Jessi Li@jess_ljx·
Excited to share our new @biorxivpreprint in which we demonstrate the formation and maintenance of cellular memories in melanoma during acquisition of therapy resistance - dependent on the transcription factor AP-1 biorxiv.org/content/10.110… (1/9)
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Keşfet

@AkankshaThawani @Columbia @ColumbiaBiochem @MoKhalilLab @shi_lingting @sun_yusha @XinW_up @piraner