Mo Khalil

Attn eVOLVER users & enthusiasts. 2 BIG developments! 1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: khalil-lab.gitbook.io/evolver/ 2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: evolver.bio/t/evolver-wiki…

Our pathogen ORFeome paper is out! In collaboration with @AlexanderStark8, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells. 1/8

@bloodgenes @Anders_S_Hansen So happy for you, Vijay! Congratulations to you and the rest of the amazing recipients.

🙏 Deeply honored to receive the 2026 Warren Alpert Prize! This award reflects the work by so many to enable transformative therapies for sickle cell disease and thalassemia, and the power of human genetics to reveal biology and guide new treatments! hms.harvard.edu/news/2026-warr…

Super excited to share this paper from @O_Farrell_Aoife!

Today I’m excited to share our new study in Nature Biomedical Engineering @natBME, in which we used protein engineering to create a therapeutic able to completely eradicate metastatic ovarian cancer in mice. 🧵 nature.com/articles/s4155…

@philippzross @willmshaw Thank you, Phil!

@MoKhalilLab @willmshaw Nice! Looking forward to reading.

🌱NEW PREPRINT & SPECIAL day! We unveil an advance for plant science, eng, and synbio in first (of many) Khalil <> Gehring collabs, led by the one-and-only @willmshaw. Thread below on principles + design of a new, single-integrating T-DNA vector for precision plant xformation! 👇

@OdedRechavi @willmshaw Thank you, Oded!

@MoKhalilLab @willmshaw Congrats Mo!

@ATinyGreenCell @willmshaw Hi Sebastian, thanks! I really enjoy following you. To answer your question, we’ve filed a provisional patent disclosure. Let us know if you’re interested in trying out the vector and toolkit!

@willmshaw @MoKhalilLab Is this patented? :)

New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @MoKhalilLab + Gehring labs biorxiv.org/content/10.648… 🧵1/16

The New World Screwworm (NWS - despite it’s name is a cousin of the blowfly 🪰) is a scourge to livestock like cattle (🐄) and other warm blooded animals larger than a squirrel (🐿️). We eradicated it in 1966 in the U.S., pushed it back to Panama thanks to the USDA and held it at bay for more than half a century. It broke through and it’s back. But we’re on it together with the @USDA and the interagency; @DARPA is developing novel technologies to safely and efficaciously eliminate the risk that invasive species’ pose! 🚫🪰 ✅🐄 🫡🇺🇸 Thank you for the highlighting coverage @DefenseScoop !

@willmshaw And here is another direct link to the preprint. Enjoy! biorxiv.org/content/10.648…

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

@anshulkundaje 100%

Please fund such tech dev and data generation efforts and please support academic labs where all this innovation is truly happening. 10/10

Academic labs continue to lead on next generation tech dev for powering AI models for biology. The next big leap in models of gene regulation will be when they truly master the long range functional architecture of the genome. 1/

Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/Jo… @ScienceMagazine

@anshulkundaje Thanks, @anshulkundaje!

@MoKhalilLab IDRs definitely have a key role in specificity. But the claims here are over the top. DBDs definitely still dominate specificity. One can see this very clearly with sequence models of multiple read outs from binding, accessibility, tx initiation, steady state tx. etc

Lovely study by the team, showing how TF specificity emerges from weak and multivalent interactions! (a property we've been obsessed with modeling, designing and engineering in cells 😍)

Great stuff, @sudpinglay and team!!

🚨 An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @HeidiKlumpe to learn more!👇 biorxiv.org/content/10.648…

Sean Eddy developed profile HMMs in the 1990s, ultimately leading to his HMMER project, which includes JackHMMER that AlphaFold relies on. Apparently his work has been determined to be "of absolutely no value to the US taxpayer". Obviously that's not true. npr.org/2026/05/21/nx-…