Mo Khalil

Attn eVOLVER users & enthusiasts. 2 BIG developments! 1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: khalil-lab.gitbook.io/evolver/ 2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: evolver.bio/t/evolver-wiki…

The manufacturing step for CAR T has always been ripe for innovation. Here, Gattinoni and Kochenderfer groups show that pharmacologic enrichment of memory-like Tscm cells boosts CD19 CAR T expansion and durable persistence in patients, even at low doses! cell.com/cell/fulltext/…

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/…

How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬 We're excited to show you how we tackle this question in our new bioRxiv pre-print! doi.org/10.64898/2026.…

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/sc… 🦠🧬🛠️🖥️💥

Breakthroughs in mammalian synthetic biology happen when bold ideas meet the right audience. Could your research define the next frontier of medicine? Submit your abstract now: bit.ly/4jQmrFj #mSBW2026 #SyntheticBiology #MammalianSystems #CallForAbstracts

New preprint alert - 5 years in the making! Using high-throughput microfluidic enzyme kinetics, we profiled 190 clinical variants of SHP2, a phosphatase linked to developmental disorders & cancer (1/8) biorxiv.org/content/10.648… @Stanford_ChEMH, @czbiohub, @bioe_stanford

Busy week for the Khalil lab getting ready of our big move next week! P.s. Graveyard of Oligos 🧬 from our prolific former postdoc @willmshaw

Interrupting the regular (science) broadcast to brag about my wife and Hisel Flynn Architects on having their beautiful work featured in the @BostonGlobe! 🏠😍 bostonglobe.com/2026/03/26/mag…

Out now! In collaboration with @LeifuChangLab, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems! Links to the articles in the following tweet:

SEED 2026 Abstract Deadline is March 8, 2026! Come join us at the premier synbio meeting in Denver! 🧬🧪🔬🦠🚀 synbioconference.org/2026

Excited to share @suminkim28 and @mileshuseyin 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: sciencedirect.com/science/articl…

Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026. This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD: careers.peopleclick.com/careerscp/clie…

My lab at Columbia University is hiring! Come join us: woappilab.com/opportunities/

What happens if you take a plant protein and transfer it into a human cell, and vice versa? We did this for 300+ proteins that regulate epigenetics & found many surprises! A toolkit for programmable transcriptional engineering across eukaryotic kingdoms tinyurl.com/ymbndjd8

@harriswangnyc @Columbia @ColumbiaMed @ColumbiaSysBio Congrats Harris! Very exciting for you and @ColumbiaSysBio.

I'm very excited to announce my official appointment as Chair of the Department of Systems Biology at @Columbia @ColumbiaMed @ColumbiaSysBio. Looking forward to more SysBio growth in NY! systemsbiology.columbia.edu

If you're doing barcoding for clone tracing, this is the construct you should use! From @RobertVandervel and @sydshaffer: easy to use and let's you trace without side reactions… and you can isolate clones by fluorescence!

FYI, Eira Bio is #hiring for a Senior Research Associate/Associate Scientist in Protein Science. This is a unique opportunity to join an exceptional team developing transformative therapies that are rapidly progressing toward the clinic. #careers" target="_blank" rel="nofollow noopener">eirabio.com/home#careers

Our company has a new name, Eira Bio (eirabio.com) (formerly K2 Tx), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design tools to discover and develop next-gen antibody-based medicines for a range of diseases!

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

Incredibly exciting and important work from @thenormanlab scaling CRISPR screens!