Paz-Ares's Lab

New insights into progenitor exhausted T cell populations dlvr.it/TTH8HV

La investigadora @zabaleta_nerea ha sido elegida académica de número de la @academia_joven por sus aportaciones científicas en el ámbito de la terapia génica. cima.cun.es/actualidad/not…

💚 Día Mundial Sin Tabaco 💚 Cambia el humo por aire. Dejar de fumar, o no empezar nunca, es uno de los mayores regalos para nuestra salud y nuestros pulmones. Desde SOSCLC-AECC seguimos impulsando la investigación, la prevención y la concienciación frente al cáncer de pulmón.💚

Celebrado el III Strategic Scientific Committee Meeting de SOSCLC-AECC en el Hospital 12 de Octubre. Investigadores e IPs de todos los Work Packages se reunieron presencialmente y online para compartir avances y seguir impulsando la investigación en cáncer de pulmón microcítico.

Excellent translational work from @BrunaPellini et al. 🔑: resistance after #KRAS #G12C inhibition may create new therapeutic vulnerabilities rather than simply closing doors. 🚪 ‼️ Implications for #ADC combinations, #HER2 assessment in #NSCLC, and post-KRAS inhibitor treatment strategies. Worth reading. 📖 🤔Could adaptive HER2 upregulation become a clinically useful biomarker, or is HER2 scoring in #lungcancer still too variable? 🧬 🫁 @KRASKickers @Exon20Group @LUNGevity #LCSM #KRASG12C @ChristianRolfo

🟢Our last paper has been published in Journal of Thoracic Oncology. Robust preclinical and early clinical data on a promising new strategy combining Irinotecan and Lurbinectedin for the treatment of SCLC jto.org/article/S1556-… @ashfromamike @IreneFerrerS @LuisPaz_Ares

👉Clinical validation that T stem cell (TSCM) memory CD8+ T cells mediate superior persistence and antitumor immunity following adoptive transfer. Congrats to Gattinoni et al. for bringing this seminal discovery full circle🧬! @uni_regensburg dlvr.it/TSJdp5

Online here: nature.com/articles/s4158… Open access here: rdcu.be/ff6YJ Key supporters of this work are @CR_UK , @CRUKLungCentre , @UCLHresearch alongside many others

♋ Si eres paciente de cáncer o familiar y quieres saber cómo se impulsa, organiza y valora la investigación clínica en oncología, quizás te interese: ✅ #H12O y AECC te invitan a un encuentro con investigadores. 🗓️ 26 Mayo. 11-14h. #somosdel12 ⏩ c.madrid/2sgh61

🚨 #Hiring: Staff Scientist/Postdoc (Non-PI) – Madrid 🇪🇸 Translational oncology: tumor biology, biomarkers & precision medicine. PhD + experience in molecular biology & preclinical models required. 👉 Apply bsoldevilla.imas12@h12o.es rolinferrer.imas12@h12o.es

Hoy celebramos el talento, la dedicación y la mirada de tantas mujeres que están cambiando el futuro de la #investigación. En @contracancerES apoyamos a 420 investigadoras, con una inversión de 68 millones de euros. #DiaInternacionaldelamujer #8M

Based on the randomized phase 3 LungTIME-C01 trial, Huang et al. reported that early time of day (ToD) treatment (before 3 pm) for the first 4 doses improved anti-PD-1 efficacy compared with late ToD treatment (after 3 pm) in patients with stage IIIC–IV NSCLC. For the early ToD group, median PFS and OS were 11.3 and 28.0 months, compared to the late ToD group, which were 5.7 and 16.8 months, respectively. Between both groups, no differences in incidence of immune-related adverse events were observed. Circulating CD8+ T cells increased in the early ToD group, with a higher activated (CD38+ HLA-DR+) versus exhausted (TIM-3+PD-1+) ratio. bit.ly/4rWdKfB

Global Immunotalks 2026 has just begun!

New #JITC article: Tumor immune microenvironment facilitates resistance to KRAS G12C inhibitor sotorasib by altered PD-L1 expression. jitc.bmj.com/content/14/2/e…

🔴Cuando decimos que la investigación puede cambiar la historia, hablamos de días como hoy. El Dr. #MarianoBarbacid y su equipo han logrado la desaparición completa y duradera del #CáncerdePáncreas en modelos experimentales 👉 criscancer.org/adenocarcinoma…

TOMORROW AT 5PM ET Lymph nodes as hubs for productive CD8 T cell immunity 📢Two papers from @KalliesLab @TheDohertyInst @UniMelb in @NatImmunol (2025)! Jan 22, 2026 | ⏰5pm ET/ 4pm CT/ 2pm PT 🔬Sharanya Wijesinghe 🧪Carlson Tsui 🎙️@dmcmanus123 Zoom: us02web.zoom.us/meeting/regist…

2026 is here! We’re excited to share Global Immunotalks first semester poster, featuring an outstanding lineup! Please share and help us spread the word!

Inflame and restrain — the paradoxical roles of IL-12 and IL-23 in immunity dlvr.it/TQFz0q

New #JITC article: In situ DC-primed vaccine combined with CD137 agonist elicits long-lasting antitumor immunity through cDC1-mediated tumor antigen-specific CD8+ T cell responses jitc.bmj.com/content/13/12/…

🍾 @LuisPaz_Ares, @JRperalto y Alberto Galindo, jefes de servicio del #H12O, médicos con la mayor reputación de España en 2025 en su especialidad ✅ Oncología Médica, Anatomía Patológica y Obstetricia y Ginecología 👏🏻 Enhorabuena. + info: c.madrid/hsuga1 #somosdel12