PengL

Real‑world, 8‑year multicancer study of lenvatinib shows manageable long‑term use across DTC, AdCC, HCC & EC. Notably, BMI declined during treatment (p=0.045), highlighting the need for closer monitoring in low‑BMI patients. 🔗 buff.ly/Ckygpuz #Lenvatinib @elenacolomboMD

French consensus published in Ther Adv Med Onc-provide practical, real‑world guidance to prevent and manage hematologic toxicities from PARPis in metastatic PC-an area of growing need. 🔗 Full article: buff.ly/9fa08rG #ProstateCancer #mCRPC #PARPInhibitors #Oncology

Real‑world evidence in Ther Adv Med Onc shows nal‑IRI/5‑FU/LV significantly improves OS in pancreatic adenocarcinoma (28.0 vs 18.3 months) despite higher cost (ICER $33,285/LYG). 🔗buff.ly/dOq2XvY #PancreaticCancer #GIOnc #RealWorldEvidence #HealthEconomics

🚀 317 R scripts for biomedical research, no coding barrier ⏱️ Standardized design saves time ✅ Verified, annotated, reproducible 🧬 Covers #scRNA-seq, spatial #transcriptomics, #ML & more Developed by @guangchuangyu and @PengL_Robin 🔗doi.org/10.1002/imm3.7… #Bioinformatics

🚨Lin et al. discuss the critical role of clinical trials in medical advancements, emphasizing their importance in verifying treatment efficacy and ensuring patient safety through rigorous study designs and data collection methods bit.ly/4nrSb3T @PengL_Robin #BMCMedicine

🎉 Milestone for #iMetaMed! We’ve just published our first paper, FastUKB 🚀 iMetaMed advances research in multi-#omics, big data, #AI & precision medicine in #healthcare. More here: onlinelibrary.wiley.com/journal/306698… @PengL_Robin

By capturing data across five spatial hierarchies (global, regional, national, subnational, local), our analysis reveals striking disparities in Covid-19 incidence, prevalence, mortality and disability; providing data to improve pandemic preparedness. onlinelibrary.wiley.com/doi/10.1002/md…

Bacterial load in #meconium onlinelibrary.wiley.com/doi/10.1002/im… #microbiome #GutHealth

Gut #microbiota reshapes #cancer #immunotherapy efficacy: Mechanisms and therapeutic strategies onlinelibrary.wiley.com/doi/full/10.10… #microbiome #tumor #MedTwitter

🚨 Exciting news! We’re launching iMetaMed, a new sub-journal of the iMeta series @iMetaScience to #medicine, #health, and #biotechnology. It aims to be a high-quality platform for global researchers and clinicians. 🔗 Learn more: onlinelibrary.wiley.com/journal/306698… @WileyHealth @WileyBiomedical @wileymicrobio

Non‐differential gut #microbes contribute to #hypertension and its severity through co‐abundances: A multi‐regional prospective #cohort study onlinelibrary.wiley.com/doi/full/10.10… #microbiome #cardiovascular #MedTwitter @wileymicrobio @WileyBiomedical @WileyHealth

Gut #microbiota in treating #inflammatory digestive diseases: Current challenges and therapeutic opportunities onlinelibrary.wiley.com/doi/full/10.10… #microbiome @wileymicrobio @WileyBiomedical @WileyHealth

MicroRNA‐microbiota interactions: Emerging strategies for modulating intestinal homeostasis and enhancing host health #iMetaOmics onlinelibrary.wiley.com/doi/full/10.10… #microbiome #microRNA #guthealth #microbiota @wileymicrobio @WileyHealth @WileyBiomedical

🔬 Our new review in Journal of Translational Medicine @BioMedCentral explores the mechanisms behind Second Primary Cancers (SPCs) - a major threat to cancer survivors Key findings: SPCs develop through multiple pathways including: • Genomic changes • Stromal cell alterations • Immune suppression • Hormonal factors 🧬 Novel research directions: • Intratumoral microbes • Single-cell multi-omics • Metabolomics Read more: [rdcu.be/d7rcC] #CancerResearch #Oncology #Cancer

This review provides a comprehensive synthesis of the current understanding of mesenchymal stem cell-derived exosomes (MSC-Exos) , underscoring their role as a novel and potent therapeutic strategy against the intricate challenges of age-related diseases. onlinelibrary.wiley.com/doi/10.1111/cp…

This review provides a comprehensive overview of the state-of-the-art in non-viral CAR-NK cell engineering, highlighting its potential to revolutionize cancer treatment. onlinelibrary.wiley.com/doi/10.1111/cp…

Gut #Bifidobacterium pseudocatenulatum protects against fat deposition by enhancing secondary #bile acid biosynthesis onlinelibrary.wiley.com/doi/full/10.10… #microbiome #guthealth @wileymicrobio @WileyBiomedical

The long‐term intake of #milk #fat does not significantly increase the blood lipid burden in normal and high‐fat diet‐fed mice onlinelibrary.wiley.com/doi/full/10.10… #microbiome #metabolism @WileyBiomedical @wileymicrobio @WileyHealth

Comparative genomic analysis of Chinese Erwinia amylovora strains reveals genetic variations, plasmid diversity, and potential common ancestor #iMetaOmics onlinelibrary.wiley.com/doi/full/10.10… #pathogen #genomics #evolution @wileymicrobio @wileyplantsci @WileyEcolEvol