Apoorva Baluapuri

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Apoorva Baluapuri

Apoorva Baluapuri

@Pol2Runner

Walter Benjamin Research Fellow @AdelmanLab @harvardmed; PhD @_WolfLab @Uni_WUE.

Boston, MA, USA Katılım Ekim 2016
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Apoorva Baluapuri
Apoorva Baluapuri@Pol2Runner·
Thrilled to see my postdoc work @AdelmanLab on the Integrator (INT) now out @CellCellPress:We found that INT deficiency allows immature and unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes
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Harvard Medical School
Harvard Medical School@harvardmed·
A new study shows mutations in the Integrator complex — linked to cancers, blood disorders, neurodevelopmental abnormalities, and other diseases — cause chronic stress in cells bit.ly/4mIdFdF
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Apoorva Baluapuri
Apoorva Baluapuri@Pol2Runner·
Amazing to see how this work connects defects in transcription elongation to chronic stress signaling and disease! Could targeting dsRNA or ISR pathways offer new therapeutic strategies for conditions caused by INT mutations? Fascinating implications for RNA biology and medicine!
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Apoorva Baluapuri
Apoorva Baluapuri@Pol2Runner·
Thrilled to see my postdoc work @AdelmanLab on the Integrator (INT) now out @CellCellPress:We found that INT deficiency allows immature and unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes
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Ernst Schmid
Ernst Schmid@ernstschmidd·
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. cell.com/molecular-cell…
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Dr. Stuti Mehta
Dr. Stuti Mehta@StutiMehtaR·
Delighted to share our #NightScience tale: "A tetramer of BCL11A is required for stable protein production & fetal hemoglobin silencing," in @ScienceMagazine. Co-led by Zheng Ge, Yin Maolu, & me, here’s a tweetorial about our puzzle-solving adventure! 1/7 tinyurl.com/2tpaaua3
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Apoorva Baluapuri
Apoorva Baluapuri@Pol2Runner·
@hilgers_lab Congrats, Valérie - great news !! Looks like an amazing end to the year and a great start in Basel. Looking forward to the nice stuff that will come of it :)
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Hilgers Lab @hilgerslab.bsky.social
Hilgers Lab @hilgerslab.bsky.social@hilgers_lab·
Very proud to have been awarded an ERC Consolidator grant for research on neuronal RNAs! Rock on, team!
MPI of Immunobiology & Epigenetics@mpi_ie

Wow. Congratulations to Valérie Hilgers (@hilgers_lab) 🎉! She has been awarded the prestigious ERC Consolidator Grant by @ERC_Research! More on her project on alternative processing of RNA molecules in neurons here: ie-freiburg.mpg.de/5985387/2024_1…

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Tycho Mevissen
Tycho Mevissen@TychoMevissen·
Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltext/…
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Irem:)
Irem:)@kaymakirrm·
My baby girl came on Monday night and closing the week with a first author paper from @DrRGJonesLab ! What a week!! Many thanks to everyone for all the efforts to get this paper out!!
Journal of Experimental Medicine@JExpMed

Kaymak, Watson @DrRGJonesLab @VAInstitute and colleagues show that production of cytosolic acetyl-CoA by ACLY and ACSS2 links CD8 T cell metabolic state and effector function through effects on #chromatin accessibility. hubs.la/Q02Lzc7r0 #Metabolism #LymphocyteBiology

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Kinga Kamieniarz-Gdula #StayWithUkraine #NCNtoTlen
Kinga Kamieniarz-Gdula #StayWithUkraine #NCNtoTlen@STOPlabPI·
Looking for an exciting #PhD project in #molecularBiology? How about this question: what determines a gene's end? Most human genes have alternative ends, the choice of which is important for health and disease. Yet we still don't understand how this choice is made!
Kinga Kamieniarz-Gdula #StayWithUkraine #NCNtoTlen tweet media
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Anshul Kundaje
Anshul Kundaje@anshulkundaje·
8) Lastly, I'm all in for meaningful public critique. We need more of them. But I absolutely despise selective pile-ons against our favorite pinatas. They r "fun drama" but a poor & lazy approach to providing feedback.
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Apoorva Baluapuri
Apoorva Baluapuri@Pol2Runner·
@_WolfLab Congrats @MV4_11 @NevenkaDudvars1 for the really nice work - great to see both histone remodelers and chaperones (SPT6) from MYC interactome in the both genetic dropout screens. A real tour de force....!
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Wolf Lab for Tumor Biochemistry
Wolf Lab for Tumor Biochemistry@_WolfLab·
Acute degradation of RUVBL1 in transplanted PDAC tumors via the auxin-inducible degron (AID) system resulted in complete tumor regression in immunocompetent mice which was preceded by infiltration with CD3-positive immune cells.
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Wolf Lab for Tumor Biochemistry
Wolf Lab for Tumor Biochemistry@_WolfLab·
We investigated the possibility of targeting the prominent oncogene MYC via its binding partners. We prioritized MYC binding partners by genetic screens in PDAC cells in culture and in immunocompetent mice.
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Eilers Lab
Eilers Lab@MYCGyvers·
After all this time? Always! The Movie-Night is back! Thank you Toshitha for our Wellness-Wednesday with Harry Potter 1️⃣! Thank you Vicky from @_BurgerLab for HP-Theme Cupcakes! Bringing culture and education to the young people in the lab 🧙‍♀️!
Eilers Lab tweet media
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Keşfet

@Wagnerlab_RNA @khurana_lab @AdelmanLab @CellCellPress @KeystoneSymp @helin_kristian @ScienceMagazine @hilgers_lab