S. pombe model organism knowledgebase

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Now in @MolecularCell: researchers led by @MarcBhler4 shed light on how transcription factors control genes in fission yeast—plus, they created FMI TFexplorer, a free tool for scientists! @PomBase Read more about this work: fmi.ch/news-events/ar…

#The Gene Ontology Consortium has launched the PAN-GO functionome, a comprehensive resource detailing functions of over 20,000 human genes, integrating evolutionary data for enhanced accuracy and insight. @KeckSchool_USC @nature doi.org/g86gqc medicalxpress.com/news/2025-02-u…

Don't miss this article published today in @NatureComms in which I have been lucky enough to participate, a beautiful work! @ibfg_es @usal @CSIC @PomBase nature.com/articles/s4146…

@pombase.bsky.social

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The Pfam protein families database: embracing AI/ML @NAR_Open 1. The latest updates to the Pfam database highlight a substantial shift towards AI integration, with Pfam-N using deep learning to increase family coverage by 8.8% in UniProtKB, offering a more expansive representation of the protein universe. 2. AlphaFold’s high-accuracy protein structure predictions play a pivotal role, helping refine domain boundaries, identify missing domains, and delineate evolutionary relationships, providing novel insights that enhance Pfam’s structural and functional annotations. 3. With Pfam’s transition to the InterPro platform, users now access an updated, unified interface for protein family data, streamlining functionality and addressing the technical debt of the legacy Pfam website. 4. The development of 710 new metagenomic families and 119 microprotein families showcases Pfam’s growing focus on underrepresented areas, filling gaps in metagenomics and uncovering roles for small proteins often overlooked in traditional annotation. 5. Collaborative efforts with ECOD (Evolutionary Classification of Protein Domains) align sequence and structural classifications, fostering a consistent, harmonized approach that enhances the utility and interpretability of domain annotations. 6. The database’s continued advancements in repeat coverage, through projects like RepeatsDB and REFRACT, support accurate annotation of repetitive protein domains, contributing valuable resources for understanding protein evolution and function. 7. AI and deep learning initiatives, including the transformer-based model InterPro-N, provide a powerful boost in identifying novel relationships and unseen family members, setting a foundation for further AI-driven innovations in protein family classification. @Alexbateman1 @andreeva789bg @matthiasblum @PfamDB @emblebi @mlbileschi_pub @Laetitia_Ppx @LucyColwell37 📜Paper: doi.org/10.1093/nar/gk… #ProteinFamilies #Bioinformatics #AlphaFold #AIinBiology #ProteinDatabase #MachineLearning

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We are pleased to announce the publication of a new Pfam paper: The Pfam protein families database: embracing AI/ML @NAR_Open academic.oup.com/nar/advance-ar…

Ready for the next #pombeTalks? 👩‍🔬✨ Season 05, Episode 03 is coming up on November 20th, 09:00 CET! Featuring @BasanteBedoya from @SophieMartinLab at @Biologie_UNIGE and @chausugu from @skmishra_iiserm 's lab at @IiserMohali. @PombeSlack, @PomBase,#pombe, #pombetalks, #yeast

Have your say about the future sustainability of biodata resources. The GBC's Open Letter campaign launches next week. It's your chance to join other high profile signatories to the letter. #biodatacounts #globalbiodata

Today is an important day for the future of global biodata resources. GBC Executive Director, @guyrcochrane writes about the significance of the Open Letter campaign in raising awareness of the issue of biodata sustainability. Click here to read blog bit.ly/4fu51eG #biodatacounts

Please sign if you can:

Our recent work indicates that about 20% of the drugs, that are most commonly given to patients that have an increased risk of a fungal infection, act not not only on the human but also on the fungal pathogen, and render them more drug resistant or tolerant.

@anshulkundaje Hey that's not boring 😕

Yes and the most boring of them all but the highest impact is dataset curation with great metadata, preprocessing and QC + expert curation of annotations and knowledge.

Our paper on a new inducible expression system for 𝘚. 𝘱𝘰𝘮𝘣𝘦 has been published. We hope this tool will benefit the fission yeast community. journals.biologists.com/jcs/article-ab…

"Since their first description in fission yeast, actomyosin clusters have been observed in the cortical actin layer beneath the plasma membrane of a large variety of animal cells and within living organisms, and they have also been reconstructed in vitro" cell.com/current-biolog…

Mitochondrial aspartate aminotransferase (maa1) inactivation causes glutamate-requiring glu1 mutation in Schizosaccharomyces pombe #micropublication #biology #data #caltechlibrary #Spombe #GenotypeData #Biochemistry #NewFinding micropublication.org/journals/biolo…

📢Excited to share our lab's @TheBraunLab latest preprint that reveals domain-specific functional pathways linked to heterochromatin regulation in S.pombe using a systematic quantitative approach. Check it out: biorxiv.org/content/10.110…

Heterochromatin: Hiding from the remodeling machines dlvr.it/TD1X1Y