Possu Huang Lab

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Possu Huang Lab

Possu Huang Lab

@PossuHuangLab

Our lab uses experimental and computational methods to design de novo proteins | @Stanford

Stanford, CA Katılım Kasım 2022
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The Mark Foundation for Cancer Research
Nikolaos Sgourakis, Mark Sellmyer (@sellmyerlab), & Possu Huang (@PossuHuangLab) are developing radioactive imaging agents to detect KRAS mutations, which drive 90% of pancreatic tumors but can’t currently be seen on scans. ☢️
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Richard Shuai
Richard Shuai@richardwshuai·
Excited by the growing interest in Caliby! Based on feedback from a few groups, we've downgraded some dependencies to support older OS versions. Please give it a try, and feel free to reach out with any issues github.com/ProteinDesignL…
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Nicole DelRosso
Nicole DelRosso@nicole_delrosso·
Tired of the bottleneck ⏳👔 between screening protein binders and actually measuring their affinities? Then check out our recent pre-print: biorxiv.org/content/10.110…
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Possu Huang Lab
Possu Huang Lab@PossuHuangLab·
Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens! SLAE reasons over atomic interactions to recover full structures and residue pairwise energetics, yielding a generalizable latent space. (1/8)
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Richard Shuai
Richard Shuai@richardwshuai·
Excited to share Caliby 🐈, our new model for structure-conditioned sequence design! Caliby is a Potts model-based sequence design method that can condition on structural ensembles. We use this to average out non-structural signal (e.g. evolutionary bias) learned by models 🧵1/N
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Hamed Khakzad
Hamed Khakzad@hamed_khakzad·
We were invited to write a preview about SHAPES, a great recent work from @PossuHuangLab. I really enjoyed this paper! It shows how far we still are from sampling the protein structural space without bias. Our preview just came out, check it out here: authors.elsevier.com/a/1ldzw8YyDfuZ…
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Possu Huang Lab
Possu Huang Lab@PossuHuangLab·
Our new set of all-atom models can sample plausible sidechains without stage-2 sampling. Sequence-dependent partial diffusion behavior occurs when we mask the dummy atoms.
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Possu Huang Lab
Possu Huang Lab@PossuHuangLab·
We have a new collection of protein structure generative models which we call Protpardelle-1c. It builds on the original Protpardelle and is tailored for conditional generation: motif scaffolding and binder generation.
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