Prebiotic Chemistry

From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth (Trapp) nature.com/articles/s4146…

Delighted to share the latest paper from our lab @COoLLabSR, which is now online @Life_MDPI We thank @IISERPune @serbonline @ugc_india for all the support. Great collaboration with Martin J. Van Kranendonk & @steller_luke from @AussieAstrobio @UNSW mdpi.com/1408722 (1/4)

Energy at Origins: Favorable Thermodynamics of Biosynthetic Reactions in the Last Universal Common Ancestor (LUCA) (Wimmer & Martin) frontiersin.org/articles/10.33…

Prebiotic membranes and micelles do not inhibit peptide formation during dehydration (Cohen & Keller) …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

New @emergenceoflife publication from Braun and Mast groups in collaboration with @DoraTang5. Happy reading! nature.com/articles/s4155…

Dynamic Exchange of Substituents in a Prebiotic Organocatalyst: Initial Steps towards an Evolutionary System (Trapp) onlinelibrary.wiley.com/doi/10.1002/an…

Acid-catalyzed RNA oligomerization from 3,5-cGMP (Braun @LMU_Muenchen, Sponer @Akademie_ved_CR, et al.) #OpenAccess through #ProjektDEAL onlinelibrary.wiley.com/doi/10.1002/ch…

The Prebiotic Kitchen: A Guide to Composing Prebiotic Soup Recipes to Test Origins of Life Hypotheses (Vincent, Colón-Santos, Cleaves, Baum, & Maurer) mdpi.com/2075-1729/11/1…

Concurrent Prebiotic Formation of Nucleoside-Amidophosphates and Nucleoside-Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization onlinelibrary.wiley.com/doi/10.1002/an…

Prebiotic photoredox synthesis from carbon dioxide and sulfite (Sutherland) nature.com/articles/s4155…

Transamination between biological keto and amino acids is typically mediated by enzymes, but metal ions can do it too. To understand how, we did a mechanistic deep dive, now out in @J_A_C_S. Congrats @RJ_Mayer, Harpreet & @SophiaRauscher!

@BiswarupJash You’re welcome!

@PrebioticChem Thank you for sharing our work :)

Single nucleotide translation without ribosomes (Richert) nature.com/articles/s4155…

Lost in Condensation: Poly-, Cyclo-, and Ultraphosphates (Jessen) pubs.acs.org/doi/abs/10.102…

The chemistry of branched condensed phosphates (Jessen) nature.com/articles/s4146…

A physicochemical orthophosphate cycle via a kinetically stable thermodynamically activated intermediate enables mild prebiotic phosphorylations (Huck) nature.com/articles/s4146…

A cyanosulfidic origin of the Krebs cycle (Ritson) science.org/doi/10.1126/sc…

Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides (Xu & Sutherland) pubs.acs.org/doi/10.1021/ja…

Wow. There's a lot to take in in this preprint from @Huckgroup, but it should be of interest to a fair few @PrebioticChem people...

Structure-activity relationships in nonenzymatic template-directed RNA synthesis (Giurgiu & Szostak) onlinelibrary.wiley.com/doi/abs/10.100…