barttels

As good a cancer piece as I’ve ever read. “Figure out what's important to you in terms of, ‘If you only had a certain amount of time left & you had the flexibility to do it, what do you want to do with that time?’” My brother has lived this for 20 years. I think about it daily.

@Stephenfdiamond @johnarnold @tab_delete Listen to him tell his own story on that podcast. I am not making this up.

@Stephenfdiamond @johnarnold @tab_delete The takedown of the Stanford president occurred when he was 17.

Highly recommend “How to Rule the World.” It’s the social commentary book of the 'fake it till you make it' era. Written by the 17-year-old who brought down Stanford’s president, it shows how a toxic mix of power, money, and hubris has transformed the school and SV more broadly.

@DrToddLee @kinsellawarren $500????????????‽!!!!!!!!!!!!!!!!!!!!😳

@kinsellawarren Function over form

Those don't look totally and completely stupid at all

@Stephenfdiamond @johnarnold @tab_delete Yes. podcasts.apple.com/us/podcast/boo…

@johnarnold @tab_delete 17?

@DoctorTro @nlmcclain @matthewherper @skathire @grok My bad.

@barttels2 @nlmcclain @matthewherper @skathire @grok Also you responded under me

Would you permanently edit the DNA of cells in your liver in order to lower your LDL cholesterol and your risk of a heart attack? Eli Lilly spent $1 billion a year ago to Verve Therapeutics, a company founded by cardiologist and geneticist @skathire on just that idea. This morning early data on the company's new experimental gene editor were published in the New England Journal of Medicine and presented at the annual meeting of the European Atherosclerosis Society in Athens. The treatment lowered LDL, which we know causes heart attacks, by 62% -- about the same amount as 10 mg of rosuvastatin plus ezetimibe. But Kathiresan points out to my colleague Jason Mast that constant LDL-lowering should work better than a pill patients often stop taking. “I treated patients for about 20 years, and you know, patients ask me all the time whether they’ll be on cholesterol medicine for the rest of their lives,” Kathiresan said. “And I think with VERVE-102 for the first time, I can tell them maybe not.” Cardiologists say it will take time, data, and experience to know if this approach is right for some people. There were no treatment-related serious adverse events in the Phase 1 study — a notable finding, given that Verve had to shelve its first candidate due to safety concerns.

@DoctorTro @nlmcclain @matthewherper @skathire @grok I thought this was a Matt Herper thread, not a “Dr Tro” thread. I have familial hypercholesterolemia so it’s a subject I’m always interested in. You and I dislike each other; let’s leave it there.

@barttels2 @nlmcclain @matthewherper @skathire @grok It wasn’t an insinuation - it was a direct accusation based on your actions You are maximally insulting but nice DARVO

@DoctorTro @nlmcclain @matthewherper @skathire @grok Your insinuation that this was anti-Christian is wholly misplaced and maximally insulting.

@barttels2 @nlmcclain @matthewherper @skathire @grok I thought my use of the words matter would have given you enough information to skip your cursory excuses You do you Next time just ask - what makes you think that? 🤔

@JeffSpartyjeff @nlmcclain @DoctorTro @matthewherper @skathire @grok The subject was cardiology.

@barttels2 @nlmcclain @DoctorTro @matthewherper @skathire @grok Jesus told these folks some stuff.

@DoctorTro @nlmcclain @matthewherper @skathire @grok UDoU

@DoctorTro @nlmcclain @matthewherper @skathire @grok I looked at her profile to see what her medical background was, and that’s all I got.

@barttels2 @nlmcclain @matthewherper @skathire @grok Words matter I guess peanut man Unless you are insulting someone’s religion

@ChefReactions His favorite dessert is probably a "dump cake," and I hope you don't even have the displeasure of knowing what that is.

@AAMortazavi @curiouswavefn Oui.

@barttels2 @curiouswavefn Brilliant 😂😂

I've always found it odd when people say that "AI will do all the tedious stuff while scientists and researchers do the advanced stuff." The problem is, you can't really reach the level of doing the advanced stuff without training yourself to do the tedious stuff. My generation might be the last one who learnt to do the tedious stuff without AI. It's going to be really interesting to see how the next generation handles this challenge.

@AAMortazavi @curiouswavefn The French also say, “You never know your family until you have shared an inheritance.” Take it to the bank ~~ or not, as the case may be.

@curiouswavefn Plus ça change, plus c’est la même chose as the French say…

@jwalkermobile @HammerHeadcases My brother would die for that. Figuratively speaking.

@HammerHeadcases One of my favorite desserts! This looks great.

My 1st successful banana cream pie. Melted dark chocolate in the crust then pressed banana slices into chocolate & let set. Added the pastry cream, another layer of bananas and just a few chocolate shavings. #yum #twittersupperclub #Food #Foodie #Baking #dessert @jwalkermobile

@CMichaelGibson Thanks for the %-age comparison. Doubtfully.

Would you have your genes edited to lower LDL by 62%, about the same as high dose statins plus ezetimibe ?

@matthewherper @skathire Skeptical sell but never say never.

@nlmcclain @DoctorTro @matthewherper @skathire @grok Did Jesus tell you this?

@DoctorTro @matthewherper @skathire @grok The first issue I have with Herper’s statement is that we “know LDL causes heart attacks”. I call BS before we even get to editing genes….

@matthewherper Not enough information in that piece. Like a 42-yo 🧍‍♀️ who had a heart attack at 42 (!!!!) and can’t be bothered to take statins every day? 😵‍💫 Details are a little scant about the woman who opted for gene editing, albeit astonishing result.

One more link: Gina Kolata at the NYT talked to a patient in the trial who loves the “one and done” approach. nytimes.com/2026/05/25/hea…

@CMichaelGibson @statnews Short step to either “whoop whoop,” or “whoops.” And an ocean of difference. Every so-called “medical” purveyor attaching to “wellness” I regard as grifters, marketers, or frauds.

After warning letter, #Whoop and FDA in discussions about controversial blood pressure feature statnews.com/2026/05/21/who… via @statnews

@eric_weinhandl I love those little dogs, if they don’t bark. Cute, wiggly, wriggly, and fun.

@barttels2 But he is half Shih Tzu, so he has a genetic predisposition to extreme laziness.

He loves the walks.