Deborah Perlstein

Congratulations to Anastasiya and Jackson and thank you for your hard work. Hopefully we will quickly go from preprint to published quickly🤞

The Answer?Nar1 engages the CTC through a bipartite binding mechanism: • a conserved electrostatic interface anchors Nar1 to an acidic surface of Cia1 • Nar1's divergent targeting complex recognition motif exploits the client recruitment site at the Cia1-Cia2 interface

NEW PREPRINT! How does the cytosolic iron-sulfur cluster assembly (CIA) targeting complex (CTC) recruit the FeS carrier Nar1? check out our paper and find out! biorxiv.org/content/10.648…

I have been learning about machine learning. If you want to learn with me, see our article! Many thanks to all the trainees who wrote and edited this mammoth of a book chapter and the reviewers for their effort! doi.org/10.1002/cpz1.7…

3) we find some of the first, direct biochemical evidence for role of the CIOA3/Nar1 protein in cluster trafficking. I hope you enjoy the paper! we are very excited to have this out there, if only in preprint form for now

2) we determine that a disease causing mutation in Cia1 results in disruption of the Cia1-Cia2 complex, and as a result, client recruitment and maturation

I had to recover my X login to share our preprint! Watch this space - exciting other papers to soon follow! biorxiv.org/content/10.110… we have been working very hard to "crack the CIA code"

Anastasiya Buzuk and colleagues from the Perlstein lab (@Prof_Perlstein) provide insight into Nar1 trafficking, CIAO2A function and CIAO1 related disease by binding studies of the CIA targetting complex and its C-terminal tryptophan containing clients. biorxiv.org/content/10.110…

Following the X-its - find me @perlstein.bsky.social. Like I have so much extra time to build a new social media. Help me out and help me find you there!

Want to work with me or one of my amazing colleagues? Attend open house for @BUChemistry tomorrow! now I am off to work on the single slide that represents my group which is orders of magnitude harder than making 10!

Watch out @ericscueny @minjung_son @Chem_Diva - the fire department inspector is on site .it will be a ruff day @BUChemistry

@JDerosaChem Tegan did a great job describing her work to me at the poster session. Any school will be lucky to recruit her!

Be on the lookout for these two rockstar undergraduate researchers as they apply to Chemistry graduate programs this Fall! 👀⚡️ #proudmentor

Congratulations to Anastasiya on receiving Pfizer Emergent Leader Award​! The Perlstein lab and your former PI are so proud of you! acswcc.org/awards/pfizer-…

Loved seeing all the chemistry at the undergraduate poster session! @derosalab @porco_lab @BUChemistry @minjung_son

Interested in completing a Masters or PhD in Chemistry? Attend our virtual admissions information session on November 13! Register at the link below: tinyurl.com/28d46upy

Aaahhh - and my undergrad mark wins NESACS travel award! Amazing work y’all. Your PI could not be more proud!

Congratulations to recent Perlstein Lab PhD student Anastasiya Buzuk on her award of the Pfizer Emergent Leader Award from @AcsWcc! I could not be more proud of you!