Derosa Lab

We are thrilled to see our collaborative work with the Gutierrez group at @uclachem published in @ACSCatalysis today! Congrats to @bryanparnitzke and team on an impressive study! More to come in this area soon, building on exciting mechanistic insights. pubs.acs.org/doi/10.1021/ac…

Congrats to @Yahuiiiiiiii and Siyuan on their Perspective in ACS Electrochemistry! We highlight strategies over the last ~10 years in Shono-type functionalization from tunable conditions to mediators, outlining exciting prospects for further development. pubs.acs.org/doi/full/10.10…

@Ella_Maru @uclachem @ACSCatalysis @bryanparnitzke Thank you!

@derosalab @uclachem @ACSCatalysis @bryanparnitzke Congratulations!

We are thrilled to see our collaborative work with the Gutierrez group at @uclachem published in @ACSCatalysis today! Congrats to @bryanparnitzke and team on an impressive study! More to come in this area soon, building on exciting mechanistic insights. pubs.acs.org/doi/10.1021/ac…

This is a really nice example of selectivity emerging from constraint, not just energetics. The Co–O–C interaction looks less like a secondary stabilisation and more like a geometric gate in configuration space, effectively collapsing the accessible pathways so the Z-product becomes the only coherent reconstruction. In that light, the DFT isn’t just explaining selectivity after the fact; it’s revealing a structure-first control mechanism, where redox mediation and MS-PCET act to maintain the constraint rather than drive the outcome. That’s an interesting direction for thinking about scalability and robustness in catalytic design. @derosalab @uclachem @ACSCatalysis

@angew_chem And a (laughably big) paper cake to celebrate! feat. Director's Cut TOC image

Congrats to Brett and Jillian on their e-SNAr strategy to enable azolation of electron-rich fluoroarenes now published in @angew_chem at a "Hot Paper"! Simple, scalable, and energy efficient - with new strategies to expand scope underway! #chemtwitter onlinelibrary.wiley.com/doi/10.1002/an…

Fantastic visit at @UniofNottingham School of Chemistry today sharing some of our recent work in @derosalab using voltage control to enable selective electrosynthesis and catalysis. Thanks to @miriamoduill for the gracious hosting and organizing great discussions with faculty!

Congrats to Zi and team on the publication of our study on a redox mediator strategy to electroreductively harness Fe(I) in alkyne semi-hydrogenation! This work is now published in @ACSCatalysis - stay tuned for more from #TeamFe. #chemtwitter #newPI pubs.acs.org/doi/10.1021/ac…

We are grateful to the @acsprf for funding our proposal on arene functionalization strategies for upconversion of aromatic feedstocks! Congrats to all the awardees this cycle: cen.acs.org/acs-news/ACS-B…

@chem_okayama Thanks, keep up the great work!

@derosalab Thank you for your response and for citing our work (Chem. Lett. 2024, 53, upae196.).I was very intrigued by your unique mechanism. Mechanisms such as the ‘SON1 mechanism (Tetrahedron 1982, 38, 1087.)’ and ‘hole catalysis (Acc. Chem. Res. 1987, 20, 371.)’ are also exciting to me.

凄く面白かった！格好いい仕事だなぁ☺️ 電解のSNArでC–N結合形成は既知 (10.1002/anie.201909983)だから、 どう差別化するのかな？と思ってたけど電子移動の形式なのね！ SNArでC–C結合作る論文 (10.1021/ja01043a028, 10.1016/j.cclet.2024.110810)はスペース的にも引用出来てないのかな？

@DMEremin Thank you!! We hope it proves useful 🙏

@derosalab is on fire with two papers back to back! Check this one out!😮

Congrats to Brett and Jillian on this incredibly powerful e-SNAr strategy! Synthetically enabling, extremely robust, and highly energy-efficient with as low as 20 mW of power at 50 mmol scale with a proposed uphill ET-promoted redox chain mechanism. Dump, stir, ⚡️ #chemtwitter

SNAr powers the engine of drug discovery and production, but electronic demands restrict access to important chemical space. We describe an e-SNAr strategy to bridge this gap that operates under air at RT with catalytic charge, simplifying scalability. chemrxiv.org/engage/chemrxi…

@Ella_Maru We have some very promising preliminary data, with lots of interesting work cut out for us - so yes, we think so! 🙂‍↕️

@derosalab Can this mediator strategy be adapted for asymmetric hydrogenation?

Harnessing reduced Fe in electrocatalysis faces many challenges with respect over-reduction and catalyst instability. In this preprint, we describe a redox mediator strategy to tame a (P3P)Fe(I) species for semi-hydrogenation of alkynes as a model study: chemrxiv.org/engage/chemrxi…

@cleanroombro Great question! With a ~400 mV gap, we're certainly threading the needle in terms of driving force. One possibility is that subsequent downhill semi-hydrogenation can drive it. Happy to discuss with more characters! Here's a great resource on mediators: pubs.rsc.org/en/content/art…

@derosalab Is Co actually acting as a mediator, though? Just from the CVs the potential is less negative than Fe, what is the driving force for the mediated redox? Maybe a silly question, sorry!

Huge congrats to our very own @bryanparnitzke for being awarded the NSF Graduate Research Fellowship! We are so proud of you! 🎉🥳 #chemtwitter #nsfgrfp

San Diego, here we come! For anyone interested in what we've been up to, please consider stopping by one of our talks next week at ACS Spring 2025! #ACSSpring2025 #chemtwitter

Congrats to Bryan on a fantastic qualifying examination! We are so proud of you! #newPI #phdlife #chemtwitter